Changes of Serum Levels of 6-Keto-PGF1α，TGF-α and TXB2 during the Treatment of Peptic Ulcer in Children and Their Influence on Prognosis

Li CAI; Huaying YANG; Jianhong CHENG; Jia CAO; Na WEI

doi:10.12259/j.issn.2095-610X.S20230928

Volume 44 Issue 9

Sep. 2023

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Li CAI, Huaying YANG, Jianhong CHENG, Jia CAO, Na WEI. Changes of Serum Levels of 6-Keto-PGF1α，TGF-α and TXB2 during the Treatment of Peptic Ulcer in Children and Their Influence on Prognosis[J]. Journal of Kunming Medical University, 2023, 44(9): 136-142. doi: 10.12259/j.issn.2095-610X.S20230928

Citation:

Li CAI, Huaying YANG, Jianhong CHENG, Jia CAO, Na WEI. Changes of Serum Levels of 6-Keto-PGF1α，TGF-α and TXB2 during the Treatment of Peptic Ulcer in Children and Their Influence on Prognosis[J]. Journal of Kunming Medical University, 2023, 44(9): 136-142. doi: 10.12259/j.issn.2095-610X.S20230928

Citation:

Li CAI, Huaying YANG, Jianhong CHENG, Jia CAO, Na WEI. Changes of Serum Levels of 6-Keto-PGF1α，TGF-α and TXB2 during the Treatment of Peptic Ulcer in Children and Their Influence on Prognosis[J]. Journal of Kunming Medical University, 2023, 44(9): 136-142. doi: 10.12259/j.issn.2095-610X.S20230928

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Changes of Serum Levels of 6-Keto-PGF1α，TGF-α and TXB2 during the Treatment of Peptic Ulcer in Children and Their Influence on Prognosis

doi: 10.12259/j.issn.2095-610X.S20230928

1.
Dept. of Pediatrics，Zigong Maternal and Child Health Hospital，Zigong Sichuan 643010
2.
Dept. of Gastroenterology，363 Hospital，Chengdu Sichuan 610041，China

Received Date: 2023-04-08
Available Online: 2023-10-16
Publish Date: 2023-09-30

Abstract

Abstract

Objective To investigate the changes of serum levels of 6-Keto-PGF1α, transforming growth factor α （TGF-α） and thromboxane B2 （TXB2） during the treatment of peptic ulcer in children, and to analyze their prognostic value. Methods 108 children with peptic ulcer from January 2019 to June 2022 were selected as the study subjects. According to the therapeutic effect of omeprazole triple therapy, they were divided into the good prognosis group （86 cases） and the poor prognosis group （22 cases）. The clinical data and serum levels of 6-Keto-PGF1α, TGF-α and TXB2 during the treatment were compared between the two groups to analyze the influence and prognostic value of each serum index on the treatment and prognosis. Results After 6 weeks of the treatment, the serum levels of 6-Keto-PGF1α and TGF-α in the poor prognosis group were higher than those in the good prognosis group, and the level of TXB2 was lower than that in the good prognosis group, and the difference of serum indexes before and after the treatment was smaller than that in the good prognosis group （P < 0.05）. The difference of serum 6-Keto-PGF1α, TGF-α and TXB2 were independently correlated with the prognosis, and the risk of adverse prognosis in positive patients was 5.804, 4.014 and 3.241 times that of negative patients respectively （P < 0.05）. The combined prediction AUC of the difference of serum indexes was greater than that of the single indexes （P < 0.05）. Conclusion The serum levels of 6-Keto-PGF1α and TGF-α increased during the treatment of peptic ulcer in children, while the levels of TXB2 decreased. The changes of serum indexes before and after treatment are closely related to poor prognosis, and the combined detection of their changes has certain predictive value for poor prognosis.
- Peptic ulcer in children,
- 6-keto prostaglandin,
- Transforming growth factor α,
- Thromboxane B2,
- Prognosis,
- Forecast

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References(27)

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