Molecular Mechanisms of Osteogenesis Promoted by Bone Repair Materials

Yunrong XU; Ziwen TANG; Fei HE

doi:10.12259/j.issn.2095-610X.S20231007

Volume 44 Issue 10

Oct. 2023

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Yunrong XU, Ziwen TANG, Fei HE. Molecular Mechanisms of Osteogenesis Promoted by Bone Repair Materials[J]. Journal of Kunming Medical University, 2023, 44(10): 168-179. doi: 10.12259/j.issn.2095-610X.S20231007

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Yunrong XU, Ziwen TANG, Fei HE. Molecular Mechanisms of Osteogenesis Promoted by Bone Repair Materials[J]. Journal of Kunming Medical University, 2023, 44(10): 168-179. doi: 10.12259/j.issn.2095-610X.S20231007

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Molecular Mechanisms of Osteogenesis Promoted by Bone Repair Materials

doi: 10.12259/j.issn.2095-610X.S20231007

Yunrong XU¹,
Ziwen TANG¹,
Fei HE^{2
,
,}

1.
Dept. of Orthopedic，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650500
2.
Dept. of Orthopedic，Qujing Affiliated Hospital of Kunming Medical University，Qujing Yunnan 655000，China

Received Date: 2023-05-18
Publish Date: 2023-10-25

Abstract

Abstract

Signal pathways including MAPK, PI3K/AKT, AMPK, TGF-β superfamily, Wnt, Hippo, NF-κB, Notch, JAK/STAT, Hedgehog, integrin, OPG/RANKL/RANK, HIF, etc. are all related to osteogenic differentiation and play a certain regulatory role in the process of bone regeneration promoted by bone repair materials. Bone repair materials such as metal materials, inorganic materials, organic polymer materials and composite materials can promote bone tissue regeneration by activating one or more signaling pathways related osteogenic. Further understanding of the molecular mechanisms underlying the promotion of osteogenesis by bone repair materials will help to broaden their application in bone tissue engineering and clinical practice. However, the specific molecular mechanisms by which bone repair materials promote osteogenesis have not yet been fully elucidated, and further research is still needed. This article briefly introduces the signal pathways related to osteogenic differentiation, summarizes the research on bone repair materials in various signal pathways, and provides a reference for the in-depth study of the mechanism of bone repair materials in promoting osteogenesis.
- Bone repair materials,
- Osteogenesis,
- Bone regeneration,
- Signaling pathways

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References(86)

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