Association between <i>TMTC1</i> Gene Polymorphisms and Schizophrenia

Tiantian CHENG; Wensa YIN; Jia WANG; Yumei LU; Xuanyu CHEN; Shengjie NIE; Linlin LIU

doi:10.12259/j.issn.2095-610X.S20231014

Volume 44 Issue 10

Oct. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(10): 161-167

Tiantian CHENG, Wensa YIN, Jia WANG, Yumei LU, Xuanyu CHEN, Shengjie NIE, Linlin LIU. Association between TMTC1 Gene Polymorphisms and Schizophrenia[J]. Journal of Kunming Medical University, 2023, 44(10): 161-167. doi: 10.12259/j.issn.2095-610X.S20231014

Citation:

Tiantian CHENG, Wensa YIN, Jia WANG, Yumei LU, Xuanyu CHEN, Shengjie NIE, Linlin LIU. Association between TMTC1 Gene Polymorphisms and Schizophrenia[J]. Journal of Kunming Medical University, 2023, 44(10): 161-167. doi: 10.12259/j.issn.2095-610X.S20231014

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Association between TMTC1 Gene Polymorphisms and Schizophrenia

doi: 10.12259/j.issn.2095-610X.S20231014

Tiantian CHENG^{1, 2},
Wensa YIN³,
Jia WANG^{1, 2, 4},
Yumei LU^{1, 2},
Xuanyu CHEN^{1, 2},
Shengjie NIE^{1, 2},
Linlin LIU^{1, 2
,
,}

1.
School of Forensic Medicine，Kunming Medical university，Kunming Yunnan 650500
2.
NHC Key Laboratory of Drug Addiction Medicine，Kunming Yunnan 650500
3.
Dept. of Medical，The Mental Hospital of Yunnan Province/The Mental Health Center Affiliated to Kunming Medical University，Kunming Yunnan 650224
4.
Clinical laboratory，Kunming Yan’an Hospital，Kunming Yunnan 650051，China

Received Date: 2023-07-26
Available Online: 2023-09-07
Publish Date: 2023-10-25

Abstract

Abstract

Objective To explore the association between single nucleotide polymorphisms of TMTC1 gene and schizophrenia. Methods A total of 207 patients with schizophrenia and 186 healthy controls were included in the study. SNPscan^TM multiplex SNP genotyping technology was used to perform genetic typing of 7 SNP loci in the TMTC1 gene. Differences in allele frequencies, genotypes, and haplotypes were compared, and the correlation between SNP loci and susceptibility to schizophrenia was analyzed under different genetic models. Results The genotype distribution of the 7 SNP sites loci is consistent with Hardy-Weinberg equilibrium. There was no statistically significant difference in the allele and genotype frequency distribution of the 7 loci between the two groups （P > 0.05）. The polymorphisms of the 7 SNP loci under different genetic models are not associated with the risk of schizophrenia （P > 0.05）. However, there is a high degree of linkage disequilibrium （LD） between rs10332 and rs16934358, rs10332 and rs2023588, rs16934358 and rs2023588, rs16934358 and rs7503. Conclusion The polymorphisms of the TMTC1 gene at rs7503, rs10332, rs2023588, rs16934358, rs2113879, rs679087, and rs4931240 sites are not associated with schizophrenia. Further analysis is needed by increasing the sample size and screening for new SNP loci.
- Schizophrenia,
- TMTC1,
- Single nucleotide polymorphism,
- Linkage disequilibrium

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References(17)

References

[1]	郝伟, 陆林主编. 精神病学[M]. 北京: 人民卫生出版社, 2018: 85-86.
[2]	Sullivan P F,Kendler K S,Neale M C. Schizophrenia as a complex trait:Evidence from a meta-analysis of twin studies[J]. Archives of General Psychiatry,2003,60(12):1187. doi: 10.1001/archpsyc.60.12.1187
[3]	Mealer R G,Williams S E,Daly M J,et al. Glycobiology and schizophrenia: A biological hypothesis emerging from genomic research[J]. Molecular Psychiatry,2020,25(12):3129-3139. doi: 10.1038/s41380-020-0753-1
[4]	Qing L,Liu L,Zhou L,et al. Sex-dependent association of mineralocorticoid receptor gene (NR3C2) DNA methylation and schizophrenia[J]. Psychiatry Research,2020,292:113318. doi: 10.1016/j.psychres.2020.113318
[5]	青丽丽. NR3C1和NR3C2基因SNP和甲基化与精神分裂症的关联性及调控机制研究[D]. 昆明: 昆明医科大学, 2022.
[6]	Birnbaum R,Weinberger D R. Genetic insights into the neurodevelopmental origins of schizophrenia[J]. Nature Reviews Neuroscience,2017,18(12):727-740. doi: 10.1038/nrn.2017.125
[7]	Williams S E,Mealer R G,Scolnick E M,et al. Aberrant glycosylation in schizophrenia: A review of 25 years of post-mortem brain studies[J]. Molecular Psychiatry,2020,25(12):3198-3207. doi: 10.1038/s41380-020-0761-1
[8]	Larsen I S B,Narimatsu Y,Joshi H J,et al. Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins[J]. Proceedings of the National Academy of Sciences,2017,114(42):11163-11168. doi: 10.1073/pnas.1708319114
[9]	Graham J B,Sunryd J C,Mathavan K,et al. Endoplasmic reticulum transmembrane protein TMTC3 contributes to O-mannosylation of E-cadherin,cellular adherence,and embryonic gastrulation[J]. Molecular Biology of the Cell,2020,31(3):167-183. doi: 10.1091/mbc.E19-07-0408
[10]	Jerber J,Zaki M S,Al-Aama J Y,et al. Biallelic mutations in TMTC3,encoding a transmembrane and TPR-containing protein,lead to cobblestone lissencephaly[J]. American Journal of Human Genetics,2016,99(5):1181-1189. doi: 10.1016/j.ajhg.2016.09.007
[11]	Farhan S M K,Nixon K C J,Everest M,et al. Identification of a novel synaptic protein,TMTC3,involved in periventricular nodular heterotopia with intellectual disability and epilepsy[J]. Human Molecular Genetics,2017,26(21):4278-4289. doi: 10.1093/hmg/ddx316
[12]	Runge C L,Indap A,Zhou Y,et al. Association of TMTC2 with human nonsyndromic sensorineural hearing loss[J]. JAMA Otolaryngology-Head & Neck Surgery,2016,142(9):866-872.
[13]	Li J,Akil O,Rouse S L,et al. Deletion of TMTC4 activates the unfolded protein response and causes postnatal hearing loss[J]. Journal of Clinical Investigation,2018,128(11):5150-5162. doi: 10.1172/JCI97498
[14]	Sunryd J C,Cheon B,Graham J B,et al. TMTC1 and TMTC2 are novel endoplasmic reticulum tetratricopeptide repeat-containing adapter proteins involved in calcium homeostasis[J]. Journal of Biological Chemistry,2014,289(23):16085-16099. doi: 10.1074/jbc.M114.554071
[15]	Ngô H M,Zhou Y,Lorenzi H,et al. Toxoplasma modulates signature pathways of human epilepsy,neurodegeneration & cancer[J]. Scientific Reports,2017,7(1):11496. doi: 10.1038/s41598-017-10675-6
[16]	Ben-Mahmoud A,Kishikawa S,Gupta V,et al. A cryptic microdeletion del(12)(p11.21p11.23) within an unbalanced translocation t(7;12)(q21.13;q23.1) implicates new candidate loci for intellectual disability and Kallmann syndrome[J]. Scientific Reports,2023,13(1):12984. doi: 10.1038/s41598-023-40037-4
[17]	Fagerberg L,Hallström B M,Oksvold P,et al. Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics[J]. Molecular & Cellular Proteomics,2014,13(2):397-406.

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