Association between <i>TMTC1</i> Gene Polymorphisms and Schizophrenia

Tiantian CHENG; Wensa YIN; Jia WANG; Yumei LU; Xuanyu CHEN; Shengjie NIE; Linlin LIU

doi:10.12259/j.issn.2095-610X.S20231014

Volume 44 Issue 10

Oct. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(10): 161-167

Tiantian CHENG, Wensa YIN, Jia WANG, Yumei LU, Xuanyu CHEN, Shengjie NIE, Linlin LIU. Association between TMTC1 Gene Polymorphisms and Schizophrenia[J]. Journal of Kunming Medical University, 2023, 44(10): 161-167. doi: 10.12259/j.issn.2095-610X.S20231014

Citation:

Tiantian CHENG, Wensa YIN, Jia WANG, Yumei LU, Xuanyu CHEN, Shengjie NIE, Linlin LIU. Association between TMTC1 Gene Polymorphisms and Schizophrenia[J]. Journal of Kunming Medical University, 2023, 44(10): 161-167. doi: 10.12259/j.issn.2095-610X.S20231014

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Association between TMTC1 Gene Polymorphisms and Schizophrenia

doi: 10.12259/j.issn.2095-610X.S20231014

Tiantian CHENG^{1, 2},
Wensa YIN³,
Jia WANG^{1, 2, 4},
Yumei LU^{1, 2},
Xuanyu CHEN^{1, 2},
Shengjie NIE^{1, 2},
Linlin LIU^{1, 2
,
,}

1.
School of Forensic Medicine，Kunming Medical university，Kunming Yunnan 650500
2.
NHC Key Laboratory of Drug Addiction Medicine，Kunming Yunnan 650500
3.
Dept. of Medical，The Mental Hospital of Yunnan Province/The Mental Health Center Affiliated to Kunming Medical University，Kunming Yunnan 650224
4.
Clinical laboratory，Kunming Yan’an Hospital，Kunming Yunnan 650051，China

Received Date: 2023-07-26
Available Online: 2023-09-07
Publish Date: 2023-10-25

Abstract

Abstract

Objective To explore the association between single nucleotide polymorphisms of TMTC1 gene and schizophrenia. Methods A total of 207 patients with schizophrenia and 186 healthy controls were included in the study. SNPscan^TM multiplex SNP genotyping technology was used to perform genetic typing of 7 SNP loci in the TMTC1 gene. Differences in allele frequencies, genotypes, and haplotypes were compared, and the correlation between SNP loci and susceptibility to schizophrenia was analyzed under different genetic models. Results The genotype distribution of the 7 SNP sites loci is consistent with Hardy-Weinberg equilibrium. There was no statistically significant difference in the allele and genotype frequency distribution of the 7 loci between the two groups （P > 0.05）. The polymorphisms of the 7 SNP loci under different genetic models are not associated with the risk of schizophrenia （P > 0.05）. However, there is a high degree of linkage disequilibrium （LD） between rs10332 and rs16934358, rs10332 and rs2023588, rs16934358 and rs2023588, rs16934358 and rs7503. Conclusion The polymorphisms of the TMTC1 gene at rs7503, rs10332, rs2023588, rs16934358, rs2113879, rs679087, and rs4931240 sites are not associated with schizophrenia. Further analysis is needed by increasing the sample size and screening for new SNP loci.
- Schizophrenia,
- TMTC1,
- Single nucleotide polymorphism,
- Linkage disequilibrium

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References(17)

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