Selection of Intensive Adjuvant Therapy for Triple-positive Breast Cancer

Chenxi LI; Zhuocen ZHA; Na LI; Lin LUO; Yang YANG; Wenlin CHEN

doi:10.12259/j.issn.2095-610X.S20231020

Volume 44 Issue 10

Oct. 2023

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Chenxi LI, Zhuocen ZHA, Na LI, Lin LUO, Yang YANG, Wenlin CHEN. Selection of Intensive Adjuvant Therapy for Triple-positive Breast Cancer[J]. Journal of Kunming Medical University, 2023, 44(10): 180-188. doi: 10.12259/j.issn.2095-610X.S20231020

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Chenxi LI, Zhuocen ZHA, Na LI, Lin LUO, Yang YANG, Wenlin CHEN. Selection of Intensive Adjuvant Therapy for Triple-positive Breast Cancer[J]. Journal of Kunming Medical University, 2023, 44(10): 180-188. doi: 10.12259/j.issn.2095-610X.S20231020

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Selection of Intensive Adjuvant Therapy for Triple-positive Breast Cancer

doi: 10.12259/j.issn.2095-610X.S20231020

3rd Dept. of Breast Surgery，Yunnan Cancer Hospital/The 3rd Affiliated Hospital of Kunming medical university，Kunming Yunnan 650118，China

Received Date: 2023-05-18
Publish Date: 2023-10-25

Abstract

Abstract

Triple-positive breast cancer （TPBC） is a special type of breast cancer characterized by the co-expression of hormone receptors （HR+） and human epidermal growth factor receptor 2 （HER2+）. Due to the regulation of the HR signaling pathway and the HER2 signaling pathway, the treatment strategy for TPBC has been a hot topic of clinical attention. There is currently a lack of systematic theoretical support for the selection of intensive adjuvant therapy for TPBC patients, including sequential or combination therapy, endocrine therapy, and targeted therapy. This review article examines 11 randomized controlled trials on TPBC treatment in recent years, obtained from database such as PUBMED, ClinicalTrials.gov, and CNKI, in order to provide clinical reference for the selection of neoadjuvant therapy strategies for TPBC.
- Triple positive breast cancer,
- Intensive adjuvant chemotherapy,
- Targeted therapy,
- Endocrine therapy

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References(45)

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