Optimization of Extraction Technology of Narciclasine from <i>Hymenocallis Littoralis</i> Based on Response Surface Method

Yun HUANG; Annan ZHAO; Qiuyue LIU; Weimin GAO; Ji LI

doi:10.12259/j.issn.2095-610X.S20231104

Volume 44 Issue 11

Nov. 2023

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Yun HUANG, Annan ZHAO, Qiuyue LIU, Weimin GAO, Ji LI. Optimization of Extraction Technology of Narciclasine from Hymenocallis Littoralis Based on Response Surface Method[J]. Journal of Kunming Medical University, 2023, 44(11): 22-28. doi: 10.12259/j.issn.2095-610X.S20231104

Citation:

Yun HUANG, Annan ZHAO, Qiuyue LIU, Weimin GAO, Ji LI. Optimization of Extraction Technology of Narciclasine from Hymenocallis Littoralis Based on Response Surface Method[J]. Journal of Kunming Medical University, 2023, 44(11): 22-28. doi: 10.12259/j.issn.2095-610X.S20231104

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Optimization of Extraction Technology of Narciclasine from Hymenocallis Littoralis Based on Response Surface Method

doi: 10.12259/j.issn.2095-610X.S20231104

Yun HUANG^{1, 2},
Annan ZHAO^{1, 2},
Qiuyue LIU¹,
Weimin GAO^{1
,
,},
Ji LI^{1
,
,}

1.
School of Pharmaceutical Sciences and Yunnan Key Laboratory of Pharmacology for Natural Products，Kunming Medical University，Kunming Yunnan 650500
2.
Yunnan Ecological Environment Monitoring Center，Kunming Yunnan 650534

Received Date: 2023-09-03
Available Online: 2023-11-11
Publish Date: 2023-11-30

Abstract

Abstract

Objective To obtain the optimal extraction process of narciclasine from Hymenocallis littoralis by response surface center design. Methods Based on the single factor experiment, temperature, time and liquid-to-solid ratio were selected to establish a mathematical model combined with the Box-Behnken test. The influence degree of the three factors on the extraction rate of narciclasine was analyzed and investigated to determine the optimal extraction conditions. Results The optimum extraction conditions were as follows: extraction temperature 90.97 ℃, extraction time 4.13 h, liquid-solid ratio 5.09 mL∶1 g. The predicted and verified values of narciclasine extraction were 3.42×10^-4% and 3.38×10^-4%, respectively. Conclusion The optimized extraction process based on the response surface method is stable, feasible, and predictable, which could be used for the extraction of active components from Hymenocallis littoralis, and has laid the groundwork for the development and utilization of Hymenocallis littoralis.
- Hymenocallis littoralis,
- Narciclasine,
- Response surface method

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References(16)

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