Volume 44 Issue 11
Nov.  2023
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Saiqiong ZHANG, Wuquan LI, Qingjiang CHEN. Clinical Efficacy of Continuous Renal Replacement Therapy in Severe Burn Sepsis[J]. Journal of Kunming Medical University, 2023, 44(11): 94-99. doi: 10.12259/j.issn.2095-610X.S20231114
Citation: Saiqiong ZHANG, Wuquan LI, Qingjiang CHEN. Clinical Efficacy of Continuous Renal Replacement Therapy in Severe Burn Sepsis[J]. Journal of Kunming Medical University, 2023, 44(11): 94-99. doi: 10.12259/j.issn.2095-610X.S20231114
shu

Clinical Efficacy of Continuous Renal Replacement Therapy in Severe Burn Sepsis

doi: 10.12259/j.issn.2095-610X.S20231114

  • Burn Research Institute，The 2nd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650101，China

  • Received Date: 2022-09-01
  • Publish Date: 2023-11-25
    Abstract
  •   Objective   To investigate the clinical efficacy of continuous renal replacement therapy（CRRT） in patients with severe burn sepsis.   Methods   Forty patients with sepsis caused by severe burns who met the inclusion criteria and were admitted to the Department of Burns of the Second Affiliated Hospital of Kunming Medical University from January 2020 to January 2023 were retrospectively analyzed. According to the treatment, patients were divided into control group and treatment group, with 20 patients in each group. The control group was given conventional symptomatic and supportive treatment, and the treatment group was given continuous renal replacement therapy on the basis of conventional treatment. The venous blood of the control group and the treatment group was taken before treatment and 24, 48, 72 hours after treatment. White blood cells（WBC）, calcitonin（PCT）, serum creatinine（Scr）, blood urea nitrogen（BUN） level. In addition, the length of hospital stay and the total cost of hospitalization were compared between the two groups.   Results   Before treatment, the levels of C-reactive protein（CRP）, interleukin-6（IL-6）, white blood cell（WBC）, procalcitonin（PCT）, serum creatinine（Scr） and blood urea nitrogen（BUN） in the two groups were compared, the P value was above 0.05, and the difference was not significant in the statistical data. 72 hours after treatment group C reactive protein（CRP） and interleukin 6（IL - 6）, white blood cell（WBC）, calcitonin（PCT）, serum creatinine（Scr）, blood urea nitrogen（BUN） level, the results show that numerical value was lower than the control group, experimental group and the difference between the P value is less than 0.05, has significant statistical significance. In addition, the length of hospital stay and total hospital costs were also statistically lower in the CRRT group than in the usual care group.   Conclusion   In severe burn patients with sepsis, continuous renal replacement therapy has a significant effect, which can effectively remove inflammatory mediators, prevent and treat uncontrolled inflammatory response, and effectively relieve the symptoms caused by systemic infections such as burn wound sepsis. It has a good application prospect in the prevention and treatment of stress injury and organ injury caused by sepsis in clinical practice. At the same time, it can also bring certain economic and social benefits.
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