Relationship between Leptin，Uric Acid，and Obesity in Type 2 Diabetes Mellitus

Ling NIU; Boyi LI; Cuijuan MIAO; Cheng ZHANG; Yan TANG; Fang LIU; Rong MA

doi:10.12259/j.issn.2095-610X.S20231121

Volume 44 Issue 11

Nov. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(11): 140-144

Ling NIU, Boyi LI, Cuijuan MIAO, Cheng ZHANG, Yan TANG, Fang LIU, Rong MA. Relationship between Leptin，Uric Acid，and Obesity in Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University, 2023, 44(11): 140-144. doi: 10.12259/j.issn.2095-610X.S20231121

Citation:

Ling NIU, Boyi LI, Cuijuan MIAO, Cheng ZHANG, Yan TANG, Fang LIU, Rong MA. Relationship between Leptin，Uric Acid，and Obesity in Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University, 2023, 44(11): 140-144. doi: 10.12259/j.issn.2095-610X.S20231121

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Relationship between Leptin，Uric Acid，and Obesity in Type 2 Diabetes Mellitus

doi: 10.12259/j.issn.2095-610X.S20231121

Dept. of Endocrinology，The 1st People’s Hospital of Kunmig，Kunming Yunnan 650011，China

Received Date: 2023-09-02
Available Online: 2023-11-09
Publish Date: 2023-11-30

Abstract

Abstract

Objective To investigate the relationship between leptin（LEP）、serum uric acid（SUA） and obese patients with type 2 diabetes mellitus（T2DM）. Methods According to body mass index（BMI）, 111 newly diagnosed T2DM patients were divided into normal weight group（69 cases） and T2DM combined with obesity group（42 cases）, The differences in LEP, sex, smoking status, age, drinking status, blood pressure, blood lipid, fasting blood glucose, OGTT-2h, glycated hemoglobin（HBA1c）, fasting insulin（FINS）, insulin 2 hours after meals, HOMR-IR and UA were compared between the two groups. Logistic regression analysis was used to screen the independent risk factors of type 2 diabetes combined with obesity. Results There were statistically significant differences in alcohol consumption, OGTT-2h, HBA1c, and UA between the two groups（P < 0.05）, but no statistically significant differences in LEP between the two groups（P > 0.05）. Regression analysis showed that UA could enter the equation, while LEP could not. Conclusions Patients with newly diagnosed type 2 diabetes, regardless of whether they are combined with obesity, have obvious insulin resistance and leptin levels. Uric acid is an independent risk factor for type 2 diabetes with obesity.
- Type 2 diabetes mellitus,
- Obesity,
- Leptin

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References(27)

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