Relationship between Leptin，Uric Acid，and Obesity in Type 2 Diabetes Mellitus

Ling NIU; Boyi LI; Cuijuan MIAO; Cheng ZHANG; Yan TANG; Fang LIU; Rong MA

doi:10.12259/j.issn.2095-610X.S20231121

Volume 44 Issue 11

Nov. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(11): 140-144

Ling NIU, Boyi LI, Cuijuan MIAO, Cheng ZHANG, Yan TANG, Fang LIU, Rong MA. Relationship between Leptin，Uric Acid，and Obesity in Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University, 2023, 44(11): 140-144. doi: 10.12259/j.issn.2095-610X.S20231121

Citation:

Ling NIU, Boyi LI, Cuijuan MIAO, Cheng ZHANG, Yan TANG, Fang LIU, Rong MA. Relationship between Leptin，Uric Acid，and Obesity in Type 2 Diabetes Mellitus[J]. Journal of Kunming Medical University, 2023, 44(11): 140-144. doi: 10.12259/j.issn.2095-610X.S20231121

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Relationship between Leptin，Uric Acid，and Obesity in Type 2 Diabetes Mellitus

doi: 10.12259/j.issn.2095-610X.S20231121

Dept. of Endocrinology，The 1st People’s Hospital of Kunmig，Kunming Yunnan 650011，China

Received Date: 2023-09-02
Available Online: 2023-11-09
Publish Date: 2023-11-30

Abstract

Abstract

Objective To investigate the relationship between leptin（LEP）、serum uric acid（SUA） and obese patients with type 2 diabetes mellitus（T2DM）. Methods According to body mass index（BMI）, 111 newly diagnosed T2DM patients were divided into normal weight group（69 cases） and T2DM combined with obesity group（42 cases）, The differences in LEP, sex, smoking status, age, drinking status, blood pressure, blood lipid, fasting blood glucose, OGTT-2h, glycated hemoglobin（HBA1c）, fasting insulin（FINS）, insulin 2 hours after meals, HOMR-IR and UA were compared between the two groups. Logistic regression analysis was used to screen the independent risk factors of type 2 diabetes combined with obesity. Results There were statistically significant differences in alcohol consumption, OGTT-2h, HBA1c, and UA between the two groups（P < 0.05）, but no statistically significant differences in LEP between the two groups（P > 0.05）. Regression analysis showed that UA could enter the equation, while LEP could not. Conclusions Patients with newly diagnosed type 2 diabetes, regardless of whether they are combined with obesity, have obvious insulin resistance and leptin levels. Uric acid is an independent risk factor for type 2 diabetes with obesity.
- Type 2 diabetes mellitus,
- Obesity,
- Leptin

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References(27)

References

[1]	Steppan C M‚Lazar M A. Resistin and obesity-associated insulin resistance[J]. Trends Endocrinol Metab,2002,13(1):18-23. doi: 10.1016/S1043-2760(01)00522-7
[2]	Thon M,Hosoi T,Chea C,et al. Loss of stearoyl-coA desaturase-1 activity induced leptin resistance in neuronal cells[J]. Biol Pharm Bull,2017,40(8):1161-1164. doi: 10.1248/bpb.b17-00311
[3]	中华医学会糖尿病学分会. 中国2型糖尿病防治指南(2020年版)[J]. 中华糖尿病杂志,2021,13(4):315-409.
[4]	Sun H,Saeedi P,Karuranga S,et al. IDF diabetes atlas: Global,regional and country-level diabetes prevalence estimates for 2021 and projections for 2045[J]. Diabetes Res Clin Pract,2022,183(8):1-13.
[5]	国家卫生计生委疾病预防控制局. 中国居民营养与慢性病状况报告（2015年）[M]. 北京: 人民卫生出版社, 2015: 3.
[6]	Xu Y, Wang L, He J, et al. Prevalence and control of diabetes in Chinese adults[J]. JAMA, 2013, 310（9）: 948-959.
[7]	Li Y, Teng D, Shi X, et al. Prevalence of diabetes recorded in Mainland of China using 2018 diagnostic criteria from the American Diabetes Association: National cross sectional study[J]. BMJ, 2020, 369: m997. Li Y, Teng D, Shi X, et al. Prevalence of diabetes recorded in Mainland of China using 2018 diagnostic criteria from the American Diabetes Association: National cross sectional study[J]. BMJ, 2020, 369: m997.
[8]	Hou X,Lu J,Weng J,et al. Impact of waist circumference and body mass index on risk of cardiometabolic disorder and cardiovascular disease in Chinese adults: A national diabetes and metabolic disorders survey[J]. PLoS One,2013,8(3):e57319. doi: 10.1371/journal.pone.0057319
[9]	Reilly M P, Iqbal N, Schutta M. et al. Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes[J]. J Clin Endocrinal Metab, 2004, 89（ 8）: 3872-3878.
[10]	Wauters M,Considine R V,Yudkin J S,et al. Leptin levels in type 2 diabetes: Associations with measures of insulin resistance and insulin secretion[J]. Hormone and Metabolic Research,2003,35(2):92-96. doi: 10.1055/s-2003-39054
[11]	Lglesias P,Díez J J. Influence of thyroid dysfunction on serum concentrations of adipocytokines[J]. Cytokine,2007,40(2):61-70. doi: 10.1016/j.cyto.2007.10.001
[12]	Gamba M, Pralong F P. Control of GnRH neuronal activity by metabolic factors: The role of leptin and insulin [J]. Mol Cell Endocrinol, 2006, 4（23）254-255: 133-139.
[13]	李宝新,郭淑芹,张灿,等. 不同BMI的2型糖尿病患者血清瘦素和神经肽 Y水平变化[J]. 重庆医学,2018,47(23):3039-3046. doi: 10.3969/j.issn.1671-8348.2018.23.010
[14]	杨朝菊, 霍丽静, 王树松. 高脂血症、糖尿病患者血清摄食抑制因子-1、脂联素和瘦素水平及其相关性[J], 中国老年学杂志, 2017, 37（6）: 1374-1376.
[15]	León-Jiménez C,Ruiz-Sandoval J L,Chiquete E,et al. Hospital arrival time and functional outcome after acute ischaemic stroke: Results from the PREMIER study[J]. Neurologia,2014,29(4):200-209.
[16]	何书连,谭丽玲,陈竑. 早期2型糖尿病患者血清内脂素与瘦素的变化及相关性分析[J]. 现代预防医学,2012,39(19):5156-5158.
[17]	Fischer S,Hanefeld M,Haffner S M,et al. Insulin0resistant patients with type 2 daibetes mellitus have higher serum Leptin levels independently of body fat mass[J]. Acta Diabetol,2002,39(3):105-110. doi: 10.1007/s005920200027
[18]	周亚茹,王战建,庞建华,等. 2型糖尿病血清瘦素浓度与胰岛素抵抗的关系[J]. 中国实用内科杂志,2005,25(11):992-993. doi: 10.3969/j.issn.1005-2194.2005.11.013
[19]	王德光,郝丽,戴宏,等. 安徽省成人慢性肾脏病流行病学调查[J]. 中华肾脏杂志,2012,28(2):101-105.
[20]	阎胜利,赵世华,李长贵,等. 山东沿海居民高尿酸血症及痛风五年随访研究[J]. 中华内分泌代谢杂志,2011,27(7):548-552.
[21]	邹贵勉,黄江燕,车文体,等. 广西城市社区居民高尿酸血症流行病学调查及其与慢性肾脏病的关系[J]. 中华内分泌代谢杂志,2011,27(7):561-565.
[22]	Luk A J,Simkin P A. Epidemiology of hypemrieemia and gout[J]. Am J ManagCare,2005,11(15):435-442.
[23]	Zhou X, Xu J. Association between serum uric acid-to-high-density lipoprotein cholesterol ratio and insulin resistance in patients with type 2 diabetes mellitus[J]. J Diabetes Investig, 2023. doi: 10.1111/jdi.14086. Online ahead of print.
[24]	Singh S K,Singh R,Singh S K,et al. Prevalence of obesity in newly onset diabetes mellitus and its relationship with uric acid: An indian cross-sectional study[J]. Int J Gen Med,2023,16:1217-1226. doi: 10.2147/IJGM.S402683
[25]	吴敏,黄淑玉,晏益民,等. 新诊断2型糖尿病伴高尿酸血症与血压及血脂相关性分析[J]. 国际医药卫生导报,2016,22(10):1406-1408. doi: 10.3760/cma.j.issn.1007-1245.2016.10.023
[26]	朱丽芹,周松兰,周琼. 高尿酸血症、2型糖尿病与代谢综合征的关系探讨[J]. 中国老年保健医学,2012,10(5):33. doi: 10.3969/j.issn.1672-4860.2012.05.014
[27]	高霜,张艳丽,吴姗姗,等. 2型糖尿病患者的糖尿病痛苦现状调查及影响因素分析[J]. 中华全科医学,2020,18(12):2136-2139.

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