Virus Genotypes and Drug Resistance among HIV/AIDS Patients before Antiretroviral Therapy in Dali Bai Autonomous Prefecture in 2018

Xiaomei JIN; Jieyan HE; Jichang SHI; Hui XING; Hong WANG; Ju ZHANG; Lijuan DONG; Lihua HUANG; Min CHEN; Zhijuan CHEN; Huichao CHEN

doi:10.12259/j.issn.2095-610X.S20231123

Volume 44 Issue 11

Nov. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(11): 152-157

Xiaomei JIN, Jieyan HE, Jichang SHI, Hui XING, Hong WANG, Ju ZHANG, Lijuan DONG, Lihua HUANG, Min CHEN, Zhijuan CHEN, Huichao CHEN. Virus Genotypes and Drug Resistance among HIV/AIDS Patients before Antiretroviral Therapy in Dali Bai Autonomous Prefecture in 2018[J]. Journal of Kunming Medical University, 2023, 44(11): 152-157. doi: 10.12259/j.issn.2095-610X.S20231123

Citation:

Xiaomei JIN, Jieyan HE, Jichang SHI, Hui XING, Hong WANG, Ju ZHANG, Lijuan DONG, Lihua HUANG, Min CHEN, Zhijuan CHEN, Huichao CHEN. Virus Genotypes and Drug Resistance among HIV/AIDS Patients before Antiretroviral Therapy in Dali Bai Autonomous Prefecture in 2018[J]. Journal of Kunming Medical University, 2023, 44(11): 152-157. doi: 10.12259/j.issn.2095-610X.S20231123

Citation:

Xiaomei JIN, Jieyan HE, Jichang SHI, Hui XING, Hong WANG, Ju ZHANG, Lijuan DONG, Lihua HUANG, Min CHEN, Zhijuan CHEN, Huichao CHEN. Virus Genotypes and Drug Resistance among HIV/AIDS Patients before Antiretroviral Therapy in Dali Bai Autonomous Prefecture in 2018[J]. Journal of Kunming Medical University, 2023, 44(11): 152-157. doi: 10.12259/j.issn.2095-610X.S20231123

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Virus Genotypes and Drug Resistance among HIV/AIDS Patients before Antiretroviral Therapy in Dali Bai Autonomous Prefecture in 2018

doi: 10.12259/j.issn.2095-610X.S20231123

1.
Institute for AIDS/STD Control and Prevention，Yunnan Provincial Center for Disease Control and Prevention，Kunming Yunnan 650022
2.
School of Public Health，Kunming Medical University，Kunming Yunnan 650500
3.
Dept. of AIDS/STD Control and Prevention，Dali Center for Disease Control and Prevention，Dali Yunnan 671000
4.
Division of Research on Virology and Immunology，Nation Center for AIDS/STD Control and Prevention，Chinese Center for Disease Control and Prevention，Beijing 102206，China

Received Date: 2023-09-01
Publish Date: 2023-11-25

Abstract

Abstract

Objective To investigate the prevalence of HIV-1 drug resistance and genotypes in HIV/AIDS patients before antiretroviral therapy in Dali Bai Autonomous Prefecture（Dali） , so as to provide a theoretical basis for more effective antiviral drug application in the clinic. Methods A total of 122 adults with HIV/AIDS on initial antiretroviral therapy were recruited in Dali from January to August 2018 before antiretroviral therapy.Amplification of HIV-1 pol genes for drug resistance analysis. Results A total of 114 samples were successfully sequenced and 7 HIV-1 genotypes were identified according to the phylogenetic analysis, including three predominant genotypes such as CRF08_BC（59.6%, 68/114）、CRF07_BC（25.4%, 29/114）and CRF01_AE（7.0%, 8/114）. The HIV-1 genotypes showed statistical differences among the main transmission route（χ² = 25.637, P < 0.001）. CRF08_BC were mainly in heterosexual and drug users, and CRF01_AE were mainly in homosexual.Surveillance drug resistance mutations（SDRMs） were 21.9%（25/114）.A higher proportion of mutations E138A（9.6%, 11/114）and V179D/E（9.6%, 11/114）were accessory drug-resistant mutations. HIV-1 drug-resistant rate was 1.8%（2/114）, and NRTIs and NNRTIs were 0.9%（1/114）respectively. Conclusion In HIV-1/AIDS patients before antiretroviral therapy in Dali, HIV-1 genotypes are multiple, with a low prevalence rate of HIV-1 drug resistance. To maintain effective public health antiretroviral therapy strategies, it is essential to strengthen the monitoring of HIV-1 drug resistance and master the data, and timely select and adjust the first-line antiretroviral therapy plan.
- HIV,
- Genotypes,
- Drug resistance,
- Antiretroviral therapy

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