Rare Cases of Hepatitis B Virus Infection Combined with Severe Cholinesterase Deficiency not Caused by Liver Dysfunction: Two Case Reports and Literature Review

Baoli BAI; Xiaolin KUANG; Mingfen HU; Guoji CHANG; Lu ZHANG; Shenghao LI; Qingqing WANG

doi:10.12259/j.issn.2095-610X.S20231210

Volume 44 Issue 12

Dec. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(12): 59-64

Baoli BAI, Xiaolin KUANG, Mingfen HU, Guoji CHANG, Lu ZHANG, Shenghao LI, Qingqing WANG. Rare Cases of Hepatitis B Virus Infection Combined with Severe Cholinesterase Deficiency not Caused by Liver Dysfunction: Two Case Reports and Literature Review[J]. Journal of Kunming Medical University, 2023, 44(12): 59-64. doi: 10.12259/j.issn.2095-610X.S20231210

Citation:

Baoli BAI, Xiaolin KUANG, Mingfen HU, Guoji CHANG, Lu ZHANG, Shenghao LI, Qingqing WANG. Rare Cases of Hepatitis B Virus Infection Combined with Severe Cholinesterase Deficiency not Caused by Liver Dysfunction: Two Case Reports and Literature Review[J]. Journal of Kunming Medical University, 2023, 44(12): 59-64. doi: 10.12259/j.issn.2095-610X.S20231210

Citation:

Baoli BAI, Xiaolin KUANG, Mingfen HU, Guoji CHANG, Lu ZHANG, Shenghao LI, Qingqing WANG. Rare Cases of Hepatitis B Virus Infection Combined with Severe Cholinesterase Deficiency not Caused by Liver Dysfunction: Two Case Reports and Literature Review[J]. Journal of Kunming Medical University, 2023, 44(12): 59-64. doi: 10.12259/j.issn.2095-610X.S20231210

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Rare Cases of Hepatitis B Virus Infection Combined with Severe Cholinesterase Deficiency not Caused by Liver Dysfunction: Two Case Reports and Literature Review

doi: 10.12259/j.issn.2095-610X.S20231210

1.
Dept. of Hepatology，Yunnan Clinical Center for Infectious Diseases/The 3rd People's Hospital of Kunming，Kunming Yunnan 650031
2.
School of Public Health，Dali University，Dali Yunnan 671000，China

Received Date: 2023-07-31
Publish Date: 2023-12-25

Abstract

Abstract

Objective To analyze the hepatitis B virus infection with extreme reduction of cholinesterase（CHE） not caused by liver synthesis dysfunction, and to explore its clinical significance. Methods The clinical data of 2 rare cases hospitalized in the 3rd people’ s hospital of Kunming in July 2021 and February 2022, including liver function, coagulation function, hepatitis B markers, hepatitis B virus volume, and whole exon sequencing, were collected and analyzed, and literature was reviewed. Results CHE was extremely reduced in 2 patients with HBV infection, liver synthesis function was good, and whole exon sequencing showed the presence of butyrylcholinesterase（BCHE） gene mutation. Conclusion The extremely low CHE in this case is not due to liver function disorder. Exon sequencing detected mutations in the BCHE gene in two patients. Screening for BCHE mutations may be necessary in patients with extremely low cholinesterase levels not due to liver dysfunction.
- Cholinesterase,
- Butyrylcholinesterase deficiency,
- Pseudocholinesterase,
- Hereditary metabolic liver disease

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References(24)

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