Application of Pre-implantation Genetic Testing in the Patients with Turner Syndrome

Zhibiao CHEN; Qiuxiang HUANG; Lihua MAO; Guoyong CHEN; Yun LIU; Zhihong WANG

doi:10.12259/j.issn.2095-610X.S20231216

Volume 44 Issue 12

Dec. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(12): 100-105

Zhibiao CHEN, Qiuxiang HUANG, Lihua MAO, Guoyong CHEN, Yun LIU, Zhihong WANG. Application of Pre-implantation Genetic Testing in the Patients with Turner Syndrome[J]. Journal of Kunming Medical University, 2023, 44(12): 100-105. doi: 10.12259/j.issn.2095-610X.S20231216

Citation:

Zhibiao CHEN, Qiuxiang HUANG, Lihua MAO, Guoyong CHEN, Yun LIU, Zhihong WANG. Application of Pre-implantation Genetic Testing in the Patients with Turner Syndrome[J]. Journal of Kunming Medical University, 2023, 44(12): 100-105. doi: 10.12259/j.issn.2095-610X.S20231216

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Application of Pre-implantation Genetic Testing in the Patients with Turner Syndrome

doi: 10.12259/j.issn.2095-610X.S20231216

1.
Dept. of Obstetrics & Gynecology
2.
Laboratory of Basic Medicine，Fuzong Clinical College，Fujian Medical University（900th Hospital of the Joint Logistics Support Force），Fuzhou Fujian 350025，China

Received Date: 2023-08-07
Available Online: 2023-12-15
Publish Date: 2023-12-25

Abstract

Abstract

Objective To investigate the application value of pre-implantation genetic testing（PGT） in patients with Turner syndrome. Methods The clinical data, embryonic development, PGT results and pregnancy outcome of 18 patients with Turner syndrome who underwent PGT in the reproductive center of 900th Hospital from January 2016 to June 2023 were retrospectively analyzed. Results All 18 patients had spontaneous puberty development, of which 4 patients had primary ovarian insufficiency（POI）. A total of 24 oocyte retrieval cycles were performed in 18 patients, of which 6 patients had no biopsied embryos for 10 cycles. Sixty-one embryos were biopsied and 60 embryos were clearly diagnosed, including 25 with chromosomal abnormalities. Seven patients with mosaic Turner syndrome obtained clinical pregnancies after transplantation, including 4 healthy boys had already been delivered and 3 are in pregnancy. Conclusion There are numerous types of karyotype in Turner syndrome. The clinical phenotypes vary greatly in individuals with Turner syndrome, and prognosis of PGT is significant different. Patients with Turner syndrome who had biopsied embryos can obtain available embryo using PGT, and achieve ideal clinical outcomes.
- Turner syndrome,
- Assisted reproductive treatment,
- Embryo,
- Preimplantation genetic testing

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References(16)

References

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