Use of Paroxetine in Outpatients of a Tertiary Psychiatric Hospital in Jiangsu Province

Yang FANG; Na WANG; Ru HUA

doi:10.12259/j.issn.2095-610X.S20231217

Volume 44 Issue 12

Dec. 2023

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2023 > 44(12): 106-110

Yang FANG, Na WANG, Ru HUA. Use of Paroxetine in Outpatients of a Tertiary Psychiatric Hospital in Jiangsu Province[J]. Journal of Kunming Medical University, 2023, 44(12): 106-110. doi: 10.12259/j.issn.2095-610X.S20231217

Citation:

Yang FANG, Na WANG, Ru HUA. Use of Paroxetine in Outpatients of a Tertiary Psychiatric Hospital in Jiangsu Province[J]. Journal of Kunming Medical University, 2023, 44(12): 106-110. doi: 10.12259/j.issn.2095-610X.S20231217

Citation:

PDF( 705 KB)

Use of Paroxetine in Outpatients of a Tertiary Psychiatric Hospital in Jiangsu Province

doi: 10.12259/j.issn.2095-610X.S20231217

Yang FANG¹,
Na WANG²,
Ru HUA^{1
,
,}

1.
Dept. of Pharmacy and Medical Equipment，Yangzhou Wutaishan Hospital/ Yangzhou Mental Health Centre，Yangzhou Jiangsu 225000
2.
Dept. of Pharmacy，Zhenjiang First Peoples Hospital，Zhenjiang Jiangsu 212000，China

Received Date: 2023-09-24
Available Online: 2023-12-20
Publish Date: 2023-12-25

Abstract

Abstract

Objective To evaluate the clinical application of paroxetine in outpatients. Methods A retrospective analysis was used to collect the prescription information of all outpatients who used paroxetine in the hospital from January 1, 2020 to June 30, 2023. The structural characteristics of patients and information on medication dosage, frequency, and cost were analyzed to evaluate the rationality of prescriptions. Results A total of 28, 106 valid prescriptions for paroxetine were included, of which 9257 were male and 18849 were female. The use of paroxetine hydrochloride tablets decreased annually while the use of enteric-coated paroxetine hydrochloride sustained-release tablets increased annually. The annual use of paroxetine hydrochloride tablets decreased, while the annual use of enteric-coated paroxetine hydrochloride sustained-release tablets increased. The average cost of the drug per patient unit dose increased each year. Non-compliant prescriptions included off-label use, improper dosage, excessive treatment duration, and off-label use in children and adolescents. Conclusion The clinical application of paroxetine is not standardized, and there are unreasonable situations such as overuse. It is necessary to further strengthen the medication management of paroxetine in outpatient patients.
- Paroxetine,
- Outpatients,
- Prescription,
- Rational use of drugs

FullText(HTML)

References(17)

References

[1]	Kowalska M,Nowaczyk J,Fijałkowski Ł,et al. Paroxetine-overview of the molecular mechanisms of action[J]. Int J Mol Sci,2021,22(4):1662. doi: 10.3390/ijms22041662
[2]	Tyrer P,Tyrer H,Yang M. Relationships between treatments received in the nottingham study of neurotic disorder over 30 years and personality status[J]. Personal Ment Health,2022,16(2):99-110. doi: 10.1002/pmh.1535
[3]	中华医学会行为医学分会,中华医学会行为医学分会认知应对治疗学组. 抑郁症治疗与管理的专家推荐意见(2022年)[J]. 中华行为医学与脑科学杂志,2023,32(3):193-202. doi: 10.3760/cma.j.cn371468-20220921-00563
[4]	龚涛,姜思思,马宁,等. 广泛性焦虑障碍基层诊疗指南(2021年)[J]. 中华全科医师杂志,2021,20(12):1232-1241. doi: 10.3760/cma.j.cn114798-20211025-00790
[5]	Gao X,Wang Z,Guo L,et al. Consensus on the pharmacological treatment of acute stress disorder in Chinese pilots: A delphi study[J]. BMC Psychiatry,2023,23(1):664. doi: 10.1186/s12888-023-05145-5
[6]	Mohseni Rad H,Zahirian Moghadam T,Hosseinkhani A,et al. Comparison of dapoxetine /tadalafil and paroxetine/tadalafil combination therapies for the treatment of the premature ejaculation: A randomized clinical trial[J]. Urol J,2021,19(2):138-143.
[7]	Önal H T,Yetkin D,Ayaz F. Paroxetine's effect on the proinflammatory cytokine stimulation and intracellular signaling pathways in J774.2 cells[J]. Naunyn Schmiedebergs Arch Pharmacol,2023,396(11):3327-3335. doi: 10.1007/s00210-023-02669-1
[8]	Feduccia A A,Jerome L,Yazar-Klosinski B,et al. Breakthrough for trauma treatment: Safety and efficacy of MDMA-assisted psychotherapy compared to paroxetine and sertraline[J]. Focus (Am Psychiatr Publ),2023,21(3):306-314.
[9]	李湘. 丁螺环酮联合帕罗西汀治疗焦虑症患者的效果[J]. 国际精神病学杂志,2023,50(1):82-85. doi: 10.13479/j.cnki.jip.2023.01.034
[10]	中华人民共和国药典. 临床用药须知·化学药和生物制品卷 [M]. 2020年版. 北京: 中国医药科技出版社, 2020: 228-229.
[11]	中华医学会,中华医学会杂志社,中华医学会全科医学分会等. 抑郁症基层诊疗指南(2021年)[J]. 中华全科医师杂志,2021,20(12):1249-1260. doi: 10.3760/cma.j.cn114798-20211020-00778
[12]	浙江华海药业股份有限公司. 盐酸帕罗西汀片说明书[DB/OL]. https://yp.120ask.com/manual/47053.html , 2023-08-10.
[13]	司天梅,王振,李凌江. 抗抑郁药品临床综合评价专家共识[J]. 中国药房,2023,34(13):1547-1554. doi: 10.6039/j.issn.1001-0408.2023.13.02
[14]	邱宏,顾文洁,刘帅,等. 基于真实世界数据的抑郁症知识图谱构建[J]. 中国卫生信息管理杂志,2023,20(2):278-284.
[15]	陈松,裴莹子,杨少杰,等. 盐酸帕罗西汀肠溶缓释片在中国健康受试者中的生物等效性研究[J]. 中国临床药理学杂志,2022,38(24):3025-3030.
[16]	Jiang L L,Wu Y L,Mo Y,et al. The effects of paroxetine therapy on depressive symptom and motor function in the treatment of depression with Parkinson's disease: A meta-analysis[J]. Medicine (Baltimore),2023,102(34):e34687.
[17]	刘晓华,彭代辉,王韵,等. 伴焦虑痛苦特征抑郁症的临床诊治专家共识[J]. 精神医学杂志,2021,34(1):74-78.

Relative Articles(20)

Relative Articles

[1]	Changji WU, Liu YANG, Xinyu ZHANG. Effects of Paroxetine and Sulpiride in the Treatment of Social Phobia in Young Women and Its Effects on Neurotransmitter and Sleep Structure. Journal of Kunming Medical University, 2023, 44(12): 159-164. doi: 10.12259/j.issn.2095-610X.S20231225
[2]	Liu LI, Yaru WANG, Di ZHANG, Qincong CHEN, Ming WANG, Shuo WANG. Application of Gene Detection for Individualized Medication for Hypertension in Patients with Grade 3 Hypertension. Journal of Kunming Medical University, 2022, 43(4): 112-117. doi: 10.12259/j.issn.2095-610X.S20220430
[3]	Hui GOU, Xian-qiong FENG, Qin ZOU. Correlation Analysis and Influencing Factors of Social Support and Medication Adherence in Patients with Psoriasis. Journal of Kunming Medical University, 2021, 42(11): 122-127. doi: 10.12259/j.issn.2095-610X.S20211122
[4]	Lin ZHANG, Sha-sha DONG, Wan-xiong WANG, Hai-fang LI. Factors Influencing Potential Inappropriate Medication Use in Elderly Patients Based on Beers Criteria 2019 Edition. Journal of Kunming Medical University, 2021, 42(12): 145-150. doi: 10.12259/j.issn.2095-610X.S20211234
[5]	Ying GAO, Mei-qi WAMG. Clinical Efficacy of Standardized Exercise Prescription Rehabilitation Training on Lumbar Intervertebral Disc Herniation. Journal of Kunming Medical University, 2021, 42(8): 148-151. doi: 10.12259/j.issn.2095-610X.S20210826
[6]	Wang Chao Qun , Niu Jie , Jiang Ping , Gao Jun Li , Meng Li Yan , Liu Hong Mei . . Journal of Kunming Medical University, 2020, 41(07): 155-159.
[7]	Tang Qi , Tian Jing , Li Quan Hong , Liu Xiao Ning , Guo Pin , Li Hui Ying , Li Gang , Chen Ya Juan . . Journal of Kunming Medical University, 2019, 40(11): 116-122.
[8]	Shi Xiao Qing , Feng Ji Hong . . Journal of Kunming Medical University, 2019, 40(02): 86-91.
[9]	Li Ya Jie , Li Hui Fen , Li Ying Fu . . Journal of Kunming Medical University, 2019, 40(09): 51-55.
[10]	Yang Zhong Qiong , Zhang Lin Yan , Feng Hua , Chen Yi Ping , Gui Li Zhu , Zhou Yu E . . Journal of Kunming Medical University, 2019, 40(09): 145-148.
[11]	Chen Xiao Hong . Influence of Continuous Nursing Intervention on Psychological Quality and Medication Compliance in Ulcerative Colitis Patients after Discharge. Journal of Kunming Medical University,
[12]	Wang Dong Mei . . Journal of Kunming Medical University,
[13]	Feng Wei . . Journal of Kunming Medical University,
[14]	Zhu Yan Ping . . Journal of Kunming Medical University,
[15]	Xing Wen Zhong . . Journal of Kunming Medical University,
[16]	Chen Jie . . Journal of Kunming Medical University,
[17]	Zhang Ji Lei . . Journal of Kunming Medical University,
[18]	Li Zhi Gui . . Journal of Kunming Medical University,
[19]	Hu Qiu Lan . . Journal of Kunming Medical University,
[20]	. Effects of Exercise Prescription on Upper Limb Function Recovery of Stroke Hemiplegia Patients. Journal of Kunming Medical University,