Association between MPV，PDW，PCT and Cardiac Function in Patients with Pulmonary Hypertension

Yan QIU; Yinli WANG; Mengmeng YANG; Liangmin GUO; Longhui YUAN

doi:10.12259/j.issn.2095-610X.S20231219

Volume 44 Issue 12

Dec. 2023

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2023 > 44(12): 121-126

Yan QIU, Yinli WANG, Mengmeng YANG, Liangmin GUO, Longhui YUAN. Association between MPV，PDW，PCT and Cardiac Function in Patients with Pulmonary Hypertension[J]. Journal of Kunming Medical University, 2023, 44(12): 121-126. doi: 10.12259/j.issn.2095-610X.S20231219

Citation:

Yan QIU, Yinli WANG, Mengmeng YANG, Liangmin GUO, Longhui YUAN. Association between MPV，PDW，PCT and Cardiac Function in Patients with Pulmonary Hypertension[J]. Journal of Kunming Medical University, 2023, 44(12): 121-126. doi: 10.12259/j.issn.2095-610X.S20231219

Citation:

PDF( 679 KB)

Association between MPV，PDW，PCT and Cardiac Function in Patients with Pulmonary Hypertension

doi: 10.12259/j.issn.2095-610X.S20231219

Dept. of Cardiovascular Medicine，The 3rd People’s Hospital of Chengdu，Chengdu Sichuan 610014，China

Received Date: 2023-08-21
Available Online: 2023-12-21
Publish Date: 2023-12-25

Abstract

Abstract

Objective To study the association between mean platelet volume（MPV）, platelet distribution width（PDW） and procalcitonin（PCT） and cardiac function in patients with pulmonary hypertension（PH） and their diagnostic value on heart failure. Methods 103 patients with PH（PH group） in the 3rd People's Hospital of Chengdu from October 2021 to October 2022 and 103 healthy subjects with physical examination（control group）were selected as study subjects. Fasting peripheral venous blood was collected on the 1st day of admission and MPV, PDW and PCT were detected. The left ventricular ejection fraction（LVEF） was measured and the cardiac function was evaluated by New York Heart Association（NYHA） grading criteria. The patients with PH were divided into failure group and non-failure group according to the diagnosis results of heart failure. The relations of MPV, PDW and PCT with cardiac function in patients with PH and the diagnostic value on heart failure were analyzed. Results The levels of MPV, PDW, and PCT were all higher in the experimental group compared to the control group, while the LVEF was lower, and these differences were statistically significant（P < 0.05）; as the NYHA classification increased, the levels of MPV, PDW, and PCT showed an increasing trend, while LVEF showed a decreasing trend, and the differences between the groups were statistically significant（P < 0.05）; in the heart failure group n = 65, the levels of MPV, PDW, and PCT were higher compared to the non-heart failure group n = 38, while LVEF was lower, and these differences were statistically significant（P < 0.05）. The levels of MPV, PDW, and PCT werr significantly positively correlated with NYHA functional classification and LVEF（P < 0.05）. The levels of MPV, PDW, and PCT had good reference value for the diagnosis of heart failure in PH patients, with AUC values of 0.816, 0.897, and 0.825 respectively, and the combined diagnostic AUC is 0.952, which wass statistically different from the application of the three indicators alone（P < 0.05）. Conclusion RDW, PDW and PCT are closely related to cardiac function in patients with PH, and can provide reference information for diagnosis and treatment of heart failure in patients with PH.
- Pulmonary hypertension,
- Cardiac function,
- Heart failure,
- Mean platelet volume,
- Platelet distribution width,
- Procalcitonin

FullText(HTML)

References(26)

References

[1]	Singh Y,Lakshminrusimha S. Pathophysiology and management of persistent pulmonary hypertension of the newborn[J]. Clin Perinatol,2021,48(3):595-618. doi: 10.1016/j.clp.2021.05.009
[2]	蒋殿虎,陈志旺,白书昌,等. 不同左心室舒张末压慢性射血分数保留性心力衰竭患者超声心动图参数差异分析[J]. 中国医学物理学杂志,2021,38(5):596-601.
[3]	Delcea C,Buzea C A,Vîjan A E,et al. The platelet to lymphocyte ratio in heart failure: A comprehensive review[J]. Rom J Intern Med,2023,61(2):84-97.
[4]	Sato M,Asagai S,Harada G,et al. Platelet volume indices correlate to severity of heart failure and have prognostic value for both cardiac and thrombotic events in patients with congenital heart disease[J]. Heart Vessels,2022,37(12):2107-2118. doi: 10.1007/s00380-022-02112-0
[5]	Menghoum N,Beauloye C,Lejeune S,et al. Mean platelet volume: A prognostic marker in heart failure with preserved ejection fraction[J]. Platelets,2023,34(1):2188965. doi: 10.1080/09537104.2023.2188965
[6]	Möckel M,de Boer R A,Slagman A C,et al. Improve management of acute heart failure with ProcAlCiTonin in EUrope: Results of the randomized clinical trial IMPACT EU Biomarkers in Cardiology (BIC) 18[J]. Eur J Heart Fail,2020,22(2):267-275. doi: 10.1002/ejhf.1667
[7]	左路广,张惠,谢桂芳,等. 血清降钙素原水平在非感染因素所致心力衰竭患者病程中的变化[J]. 中国医药,2021,16(10):1525-1528.
[8]	中华医学会呼吸病学分会肺栓塞与肺血管病学组,中国医师协会呼吸医师分会肺栓塞与肺血管病工作委员会,全国肺栓塞与肺血管病防治协作组,等. 中国肺动脉高压诊断与治疗指南(2021版)[J]. 中华医学杂志,2021,101(1):11-51.
[9]	中华医学会心血管病学分会心力衰竭学组,中国医师协会心力衰竭专业委员会,中华心血管病杂志编辑委员会. 中国心力衰竭诊断和治疗指南2018[J]. 中华心血管病杂志,2018,46(10):760-789.
[10]	赵智慧,姜莉,王俊青. 实时三维超声心动图评价不同左室构型高血压病患者左房功能[J]. 临床超声医学杂志,2021,23(3):236-239.
[11]	Castiglione V,Aimo A,Vergaro G,et al. Biomarkers for the diagnosis and management of heart failure[J]. Heart Fail Rev,2022,27(2):625-643. doi: 10.1007/s10741-021-10105-w
[12]	张颖,田毅,朱紫薇,等. 门控心肌灌注/代谢显像动态评估小型猪室壁瘤模型左心室功能及心室重构[J]. 中华核医学与分子影像杂志,2019,39(7):420-422.
[13]	张玉海,李力兵,王亮,等. 间充质干细胞治疗肺动脉高压所致右心衰竭的研究进展[J]. 中华胸心血管外科杂志,2022,38(8):504-507.
[14]	Al-Qazazi R,Lima P D A,Prisco S Z,et al. Macrophage-NLRP3 Activation promotes right ventricle failure in pulmonary arterial hypertension[J]. Am J Respir Crit Care Med,2022,206(5):608-624. doi: 10.1164/rccm.202110-2274OC
[15]	Cassady S J,Ramani G V. Right heart failure in pulmonary hypertension[J]. Cardiol Clin,2020,38(2):243-255. doi: 10.1016/j.ccl.2020.02.001
[16]	陆云燕,魏文娟. 平均血小板体积与慢性心力衰竭的相关性[J]. 心脑血管病防治,2019,19(6):531-533.
[17]	王婷,赵连山,张亮,等. 血小板体积分布宽度评估急性心力衰竭患者预后的价值[J]. 中国分子心脏病学杂志,2022,22(3):4668-4673.
[18]	Yaku A,Inagaki T,Asano R,et al. Regnase-1 prevents pulmonary arterial hypertension through mRNA degradation of interleukin-6 and platelet-derived growth factor in alveolar macrophages[J]. Circulation,2022,146(13):1006-1022. doi: 10.1161/CIRCULATIONAHA.122.059435
[19]	Delaney C,Davizon-Castillo P,Allawzi A,et al. Platelet activation contributes to hypoxia-induced inflammation[J]. Am J Physiol Lung Cell Mol Physiol,2021,320(3):L413-L421. doi: 10.1152/ajplung.00519.2020
[20]	Siniarski A,Gąsecka A,Borovac J A,et al. Blood coagulation disorders in heart failure: From basic science to clinical perspectives[J]. J Card Fail,2023,29(4):517-526. doi: 10.1016/j.cardfail.2022.12.012
[21]	Hanna A,Frangogiannis N G. Inflammatory cytokines and cemokines as therapeutic targets in heart failure[J]. Cardiovasc Drugs Ther,2020,34(6):849-863. doi: 10.1007/s10557-020-07071-0
[22]	Said E A,Al-Reesi I,Al-Shizawi N,et al. Defining IL-6 levels in healthy individuals: A meta-analysis[J]. J Med Virol,2021,93(6):3915-3924. doi: 10.1002/jmv.26654
[23]	余志艳,彭松,江涛,等. 慢性肺源性心脏病患者血清白细胞介素-6、降钙素原、D-二聚体、N端B型脑钠肽前体与心功能分级和预后的关系研究[J]. 现代生物医学进展,2022,22(24):4714-4719,4724.
[24]	陈保花,Agyekum GA,何婷婷,等. 雌二醇/睾酮比值、白细胞介素6、降钙素原水平与慢性心衰的关系[J]. 中国循证心血管医学杂志,2021,13(12):1496-1501.
[25]	Velissaris D,Zareifopoulos N,Lagadinou M,et al. Procalcitonin and sepsis in the emergency department: An update[J]. Eur Rev Med Pharmacol Sci,2021,25(1):466-479.
[26]	梁彦群,王文棣,范文文. PCT、D-dimer和NT-proBNP水平及肺功能与儿童喘息性疾病相关肺动脉高压关系[J]. 青岛大学学报(医学版),2021,57(4):589-592.

Relative Articles(20)

Relative Articles

[1]	Tuan LI, Yu’e ZHOU, Li MA, Gui LIAO. Clinical Significance of C Reactive Protein and Procalcitonin Detection in Neonatal ABO Hemolytic Jaundice. Journal of Kunming Medical University, 2023, 44(1): 80-84. doi: 10.12259/j.issn.2095-610X.S20230122
[2]	Mei YANG, Ping WANG, Hui YANG, Gonghao HE. Potential Therapeutic Targets and Research Progress of Related Drugs of Heart Failure. Journal of Kunming Medical University, 2023, 44(7): 156-161. doi: 10.12259/j.issn.2095-610X.S20230719
[3]	Ruyi FANG, Honglu LIU, Haiwen LI, Xi CHENG, Yangjun CHEN, Yushan LI, Yongrui YANG, Nihong LU. Effects of MMP-1 and MMP-7 on Pulmonary Hypertension in Rats. Journal of Kunming Medical University, 2023, 44(3): 34-43. doi: 10.12259/j.issn.2095-610X.S20230305
[4]	Meng SHANG, Xiaolong GAO, Xiaohui KUANG, Xi ZHANG, Jin ZHANG, Lilin WANG. Application of Sacubitril/valsartan in Patients with Chronic Heart Failure Implanted with Implantable Cardioverter Defibrillators. Journal of Kunming Medical University, 2023, 44(11): 63-69. doi: 10.12259/j.issn.2095-610X.S20231109
[5]	Hai-ping ZHANG, Shu-juan YANG, Li-xia YANG, Zhao-juan RUAN, Rui-wei GUO. Effect of Hyperhomocysteinemia on Cardiac Function and Mortality of Patients with Acute Myocardial Infarction Concomitant Hypertension underwent Primary Percutaneous Coronary Intervention after 6 Months. Journal of Kunming Medical University, 2021, 42(3): 73-78. doi: 10.12259/j.issn.2095-610X.S20210319
[6]	Wei-wen WANG, De-xia LI, Jie ZHANG, Lin LI. Correlation Between Serum Soluble ST2 and Cardiac Remodeling in Patients with Heart Failure with Reduced Ejection Fraction. Journal of Kunming Medical University, 2021, 42(8): 71-77. doi: 10.12259/j.issn.2095-610X.S20210813
[7]	Jian-pei SU, Wei-meng TIAN, Jun GU, Mi-yu HE. Association between C-reactive Protein/Albumin Ratio and Long-term Prognosis in Elderly Patients with Heart Failure. Journal of Kunming Medical University, 2020, 41(12): 128-132. doi: 10.12259/j.issn.2095-610X.S20201236
[8]	Jie Chun Lin , Huang Tao , Teng Zhao Wei , Bu Jun Hui , Li Meng Zhou , Zhang Jing. . Journal of Kunming Medical University, 2019, 40(04): 91-96.
[9]	Wang Zheng Quan . Significance of Platelet Distribution Width and Mean Platelet Volume in the Prognosis of Chronic Obstructive Pulmonary Disease Combined with Pulmonary Artery Hypertension. Journal of Kunming Medical University,
[10]	Wang Yu . . Journal of Kunming Medical University,
[11]	Guang Xue Feng . . Journal of Kunming Medical University,
[12]	Ma Jia . . Journal of Kunming Medical University,
[13]	Xue Qiang . . Journal of Kunming Medical University,
[14]	Lu Yi Bing . . Journal of Kunming Medical University,
[15]	Dai Hai Long . . Journal of Kunming Medical University,
[16]	Gao Zhan . . Journal of Kunming Medical University,
[17]	Chen Li Xing . . Journal of Kunming Medical University,
[18]	Yin Fan . . Journal of Kunming Medical University,
[19]	Chang Song Jie . . Journal of Kunming Medical University,
[20]	Yang Jing . . Journal of Kunming Medical University,