Epidemiology of CRKP Infection Outbreak in a Neonatal Intensive Care Unit

Weijie LI; Liqin CHEN; Yaling LI; Yonghui HAN; Xiaojuan LI; Ruogu WANG

doi:10.12259/j.issn.2095-610X.S20231223

Volume 44 Issue 12

Dec. 2023

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Weijie LI, Liqin CHEN, Yaling LI, Yonghui HAN, Xiaojuan LI, Ruogu WANG. Epidemiology of CRKP Infection Outbreak in a Neonatal Intensive Care Unit[J]. Journal of Kunming Medical University, 2023, 44(12): 144-149. doi: 10.12259/j.issn.2095-610X.S20231223

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Epidemiology of CRKP Infection Outbreak in a Neonatal Intensive Care Unit

doi: 10.12259/j.issn.2095-610X.S20231223

Infection Management Department，Kunming Children's Hospital，Kunming Yunnan 650228，China

Received Date: 2023-09-20
Available Online: 2023-12-20
Publish Date: 2023-12-25

Abstract

Abstract

Objective To analyze the epidemiological characteristics of an outbreak of carbapenem resistant Klebsiella pneumoniae（CRKP） hospital infection in the neonatal intensive care unit（NICU） , and to explore possible causes of the outbreak. Methods Case analysis, epidemiological studies and environmental detection methods were used to investigate the detection of CRKP in the NICU of a hospital from March 11, 2022 to May 3, 2022, and the causes and corresponding prevention and control measures were analyzed. Results This CRKP outbreak in the NICU occurred in two phases. The first phase was from March 11, 2022, to March 30, 2022, during which 3 people contracted CRKP hospital infections. The second phase was from April 13, 2022, to May 3, 2022, during which 4 people contracted CRKP hospital infections. The source of the hospital infection outbreak was patient No.1. All 13 CRKP cases showed sensitivity only to amikacin and tigecycline, with intermediate sensitivity to levofloxacin, and high resistance to other antibiotics. All 13 CRKP cases carried resistant genes for metalloenzymes. After the outbreak, the ward environment was sampled three times, with 35 samples taken in total, and 14 of them tested positive for CRKP. After strict environmental cleaning, disinfection, and multiple control measures, no new hospital infection cases similar to this outbreak were detected after May 13, 2022. Conclusion The outbreak of NICU hospital infections may be due to the contamination of the ward environment, medical equipment, and inadequate hand hygiene of medical staff, leading to its spread. Therefore, strict cleaning and disinfection of the environmental surfaces, strengthening hand hygiene of medical staff, and implementing multiple measures can effectively control hospital infections of CRKP.
- CRKP,
- Hospital Infection,
- Newborns,
- Hospital Infection Outbreak,
- Epidemiology

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