Effects of Paroxetine and Sulpiride in the Treatment of Social Phobia in Young Women and Its Effects on Neurotransmitter and Sleep Structure

Changji WU; Liu YANG; Xinyu ZHANG

doi:10.12259/j.issn.2095-610X.S20231225

Volume 44 Issue 12

Dec. 2023

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2023 > 44(12): 159-164

Changji WU, Liu YANG, Xinyu ZHANG. Effects of Paroxetine and Sulpiride in the Treatment of Social Phobia in Young Women and Its Effects on Neurotransmitter and Sleep Structure[J]. Journal of Kunming Medical University, 2023, 44(12): 159-164. doi: 10.12259/j.issn.2095-610X.S20231225

Citation:

Changji WU, Liu YANG, Xinyu ZHANG. Effects of Paroxetine and Sulpiride in the Treatment of Social Phobia in Young Women and Its Effects on Neurotransmitter and Sleep Structure[J]. Journal of Kunming Medical University, 2023, 44(12): 159-164. doi: 10.12259/j.issn.2095-610X.S20231225

Citation:

Changji WU, Liu YANG, Xinyu ZHANG. Effects of Paroxetine and Sulpiride in the Treatment of Social Phobia in Young Women and Its Effects on Neurotransmitter and Sleep Structure[J]. Journal of Kunming Medical University, 2023, 44(12): 159-164. doi: 10.12259/j.issn.2095-610X.S20231225

PDF( 991 KB)

Effects of Paroxetine and Sulpiride in the Treatment of Social Phobia in Young Women and Its Effects on Neurotransmitter and Sleep Structure

doi: 10.12259/j.issn.2095-610X.S20231225

1.
Rehabilitation Department
2.
The 4th Psychiatry Department
3.
The 2nd Psychiatry Department，Shalingzi Hospital，Zhangjiakou City, Zhangjiakou Hebei 075000，China

Received Date: 2023-10-07
Available Online: 2023-12-19
Publish Date: 2023-12-25

Abstract

Abstract

Objective To explore the effects of paroxetine and sulpiride in the treatment of social phobia in young women and the effects on neurotransmitters and sleep structure. Methods 102 young female patients with social phobia in our hospital from February 2021 to February 2023 were selected and divided into 2 groups with 51 cases in each group by random number table method. The control group was treated with Paxil, and the study group was treated with Paxil + sulpiride for 3 months. Treatment effect, neurotransmitters [5-hydroxytryptamine（5-HT）, dopamine（DA）, gamma-aminobutyric acid（GABA）, myeloperoxidase（MPO）], sleep structure, social anxiety（LASA）, social fear（SPS） and social Results The research group's overall effective rate of treatment is 88.24%, which is higher than the control group's 70.59%（P<0.05）. 1 month and 3 months after treatment, the research group's serum levels of DA and MPO are lower than those of the control group, while the levels of 5-HT and GABA are higher than those of the control group（P<0.05）. 1 month and 3 months after treatment, the research group's sleep transition frequency and the proportion of stage I + stage II are lower than those of the control group, while the proportion of stage III + stage IV and REM stage are higher than those of the control group（P<0.05）. 1 month and 3 months after treatment, the research group's LASA, SPS, and SAFE scores are lower than those of the control group（P<0.05）; The incidence of adverse events in the research group is 13.73% compared to 9.80% in the control group, with no statistically significant difference（P>0.05）. Conclusion Paroxetine and sulpiride combined can improve the sleep structure of young women with social phobia, regulate serum neurotransmitter levels, alleviate social anxiety symptoms, improve social adaptability, and have a certain level of safety.
- Social phobia,
- Sulpride,
- Paroxetine,
- Sleep structure,
- Neurotransmitter

FullText(HTML)

References(22)

References

[1]	Tibi L,Asher S,van Oppen P,et al. The correlates of social phobia in OCD: Findings from a large clinical sample[J]. Br J Clin Psychol,2021,60(3):312-332. doi: 10.1111/bjc.12292
[2]	Probst T,Berger T,Meyer B,et al. Social phobia moderates the outcome in the EVIDENT study: A randomized controlled trial on an Internet-based psychological intervention for mild to moderate depressive symptoms[J]. J Consult Clin Psychol,2020,88(1):82-89. doi: 10.1037/ccp0000441
[3]	Li L,Han Z,Li L,et al. Effectiveness of paroxetine for poststroke depression: A meta-analysis[J]. J Stroke Cerebrovasc Dis,2020,29(5):104664. doi: 10.1016/j.jstrokecerebrovasdis.2020.104664
[4]	Naguy A. Sulpiride for autism spectrum disorder[J]. Prim Care Companion CNS Disord,2021,23(5):20l02822.
[5]	王春雨,储华. 文拉法辛联合舒必利治疗社交恐惧症的临床疗效[J]. 临床合理用药杂志,2019,12(12):83-84. doi: 10.15887/j.cnki.13-1389/r.2019.12.040
[6]	中华医学会精神科分会. CCMD-3中国精神障碍分类与诊断标准[M]. 山东科学技术出版社, 2001: 43.
[7]	何燕玲,张明园. LieboWitZ社交焦虑量表的信度和效度研究[J]. 诊断学理论与实践,2004,3(2):89-93. doi: 10.3969/j.issn.1671-2870.2004.02.009
[8]	叶冬梅,钱铭怡,刘兴华,等. 社会交往焦虑量表和社交恐惧量表的修订[J]. 中国临床心理学杂志,2007,15(2):115-117. doi: 10.3969/j.issn.1005-3611.2007.02.002
[9]	Duan S,Lee M,Wolf J,et al. Higher depressive symptoms predict lower social adaptive functioning in children and adolescents with ASD[J]. J Clin Child Adolesc Psychol,2022,51(2):203-210. doi: 10.1080/15374416.2020.1750020
[10]	Caponnetto P,Triscari S,Maglia M,et al. The simulation game-virtual reality therapy for the treatment of social anxiety disorder: A systematic review[J]. Int J Environ Res Public Health,2021,18(24):13209. doi: 10.3390/ijerph182413209
[11]	Alomari N A,Bedaiwi S K,Ghasib A M,et al. Social anxiety disorder: Associated conditions and therapeutic approaches[J]. Cureus,2022,14(12):e32687.
[12]	Muris P,Ollendick T H. Selective mutism and its relations to social anxiety disorder and autism spectrum disorder[J]. Clin Child Fam Psychol Rev,2021,24(2):294-325. doi: 10.1007/s10567-020-00342-0
[13]	Villanueva J,Meyer AH,Mikoteit T,et al. Having versus not having social interactions in patients diagnosed with depression or social phobia and controls[J]. PLoS One,2021,16(4):e0249765. doi: 10.1371/journal.pone.0249765
[14]	赵春龙,张涛. 左侧背外侧前额叶rTMS联合帕罗西汀治疗抑郁症的效果及对患者血清神经递质的影响[J]. 海南医学,2023,34(5):629-632.
[15]	周岩,李莹,郝腾,等. 益气养心安神汤联合帕罗西汀对抑郁症失眠气郁痰阻证患者HAMD、CGI评分的影响[J]. 辽宁中医杂志,2023,50(1):62-65.
[16]	Leisman G,Sheldon D. Tics and emotions[J]. Brain Sci,2022,12(2):242. doi: 10.3390/brainsci12020242
[17]	李杰,赵金香,魏丽宁,等. 度洛西汀联合小剂量舒必利治疗躯体化障碍随机对照研究[J]. 河北医药,2020,42(23):3560-3563.
[18]	张孜,杨烨,李晓琳,等. 基于治疗药物浓度监测的舒必利剂量校正浓度的影响因素分析[J]. 中国临床药理学杂志,2023,39(1):13-16.
[19]	杨柳,周云云. 帕罗西汀联合小剂量舒必利治疗社交恐惧合并抑郁的疗效[J]. 中国健康心理学杂志,2018,26(6):4. doi: 10.13342/j.cnki.cjhp.2018.06.003
[20]	Dos Santos R G,Bouso J C,Alcázar-Córcoles M Á,et al. Efficacy,tolerability,and safety of serotonergic psychedelics for the management of mood,anxiety,and substance-use disorders: A systematic review of systematic reviews[J]. Expert Rev Clin Pharmacol,2018,11(9):889-902. doi: 10.1080/17512433.2018.1511424
[21]	郭虹,李云鹏,王超敏,等. 艾司西酞普兰联合心理疗法对焦虑症患者睡眠质量、生活质量和血清神经递质水平的影响[J]. 现代生物医学进展,2021,21(6):1059-1063. doi: 10.13241/j.cnki.pmb.2021.06.013
[22]	Aledavood T,Torous J,Triana Hoyos A M,et al. Smartphone-based tracking of sleep in depression,anxiety,and psychotic disorders[J]. Curr Psychiatry Rep,2019,21(7):49. doi: 10.1007/s11920-019-1043-y

Relative Articles(20)

Relative Articles

[1]	Sifan DUAN, Mengmei LIU, Yani LI, Dingyun YOU. Entropy、Dissipative Structure And Health. Journal of Kunming Medical University, 2024, 45(3): 1-6. doi: 10.12259/j.issn.2095-610X.S20240301
[2]	Yanyu CHEN, Jun YU, Shaomei YOU, Jian CHEN. Visualization Analysis of Kinesiophobia Research Field Based on VOSviewer. Journal of Kunming Medical University, 2024, 46(): 1-8.
[3]	Junfang YANG, Lantian LOU, Fayan ZHENG, Yunna LI, Jiamei SONG. Effect of Narrative Nursing on Negative Emotions，Sleep Quality and Nursing Satisfaction of RSA Patients. Journal of Kunming Medical University, 2023, 44(8): 167-171. doi: 10.12259/j.issn.2095-610X.S20230818
[4]	Kang HUANG, Zhirong ZHAO, Haiwen LI, Ti WU, Ting JIA, Lu WANG, Nihong LU, Yongrui YANG. Efficacy and Safety of Sofosbuvir/Velpatasvir with or without Ribavirin in Cirrhotic Patients with Genotype 3 Chronic Hepatitis C Infection. Journal of Kunming Medical University, 2023, 44(11): 126-134. doi: 10.12259/j.issn.2095-610X.S20231119
[5]	Junhan ZHAO, Ping LUO, Juli MA. Survey on the Current Status of Social Anxiety in Children with Leukemia. Journal of Kunming Medical University, 2023, 44(11): 87-93. doi: 10.12259/j.issn.2095-610X.S20231113
[6]	Yang FANG, Na WANG, Ru HUA. Use of Paroxetine in Outpatients of a Tertiary Psychiatric Hospital in Jiangsu Province. Journal of Kunming Medical University, 2023, 44(12): 106-110. doi: 10.12259/j.issn.2095-610X.S20231217
[7]	Xinyuan HUANG, Shu MA, Fanyi KONG, Mingsheng WANG. The Effectiveness of White Noise Intervention for Improving Subjective Sleep Quality and Anxiety of Militaries Living at the High Altitude. Journal of Kunming Medical University, 2022, 43(9): 130-134. doi: 10.12259/j.issn.2095-610X.S20220918
[8]	Zhi-rong ZHAO, Hai-wen LI, Xiao-fei LI, Ni-hong LU, Yong-rui YANG. Efficacy and Safety of Sofosbuvir/Vipatavir Combined with Ribavirin in Treatment of Genotype 3 Patients with Chronic Hepatitis C. Journal of Kunming Medical University, 2021, 42(3): 98-103. doi: 10.12259/j.issn.2095-610X.S20210325
[9]	Liu Shao Xing , Xie Xian Feng , Cao De Jun . . Journal of Kunming Medical University, 2020, 41(01): 37-41.
[10]	Dai Yi Cong , Chen Feng Rong , Wang Kun Hua . . Journal of Kunming Medical University, 2020, 41(09): 142-148.
[11]	Gao Qing , Xie Xing , Luo Li . . Journal of Kunming Medical University, 2020, 41(09): 77-81.
[12]	Zhao Xin Mei , Li Jun Mei , Yang Ju Hua , Zhao Cun Na , Zhang Pei , Huang Xiao , Wang Xiao Yan , Li Hai , Zhang Yuan Fei . . Journal of Kunming Medical University, 2019, 40(05): 144-148.
[13]	Lin Yuan Yuan , Yuan Jing , Zeng Lei , Wei Yu Jun , Zhang Yan , Xu Li , Yang Jian Zhong . Association between Polymorphisms of rs3924999, rs35753505 in NRG1 Gene and the Efficacy of Risperidone in Patients with Schizophrenia. Journal of Kunming Medical University, 2018, 39(06): 76-81.
[14]	Chen Xue Qiang , Huang Chun Gui , Yu Li Xian , Yang Yun Li . The Effect of PCSA with Parecoxib Sodium and Sufentanil on the Postoperative Delirium in Patients after the Spinal Surgery. Journal of Kunming Medical University, 2018, 39(01): 92-95.
[15]	Lei Jie Peng , Yang Li , Luo Cheng , Zhang Ti Yuan , Lv Xin , Li Sheng Qiao , Lin Hai Bo . Comparative Study of Paliperidone ER Tablets and Risperidone Tablets in Treatment of Childhood and Adolescents First Episode Schizophrenia. Journal of Kunming Medical University, 2017, 38(09): 92-95.
[16]	Ke Ting Yu . . Journal of Kunming Medical University,
[17]	Deng Zheng . . Journal of Kunming Medical University,
[18]	. . Journal of Kunming Medical University,
[19]	. Curative Effects of Integrating Pantoprazole and Mosapride on Gastroesophageal Reflux Disease after Esophagectomy. Journal of Kunming Medical University,
[20]	Yang Xi Yun . . Journal of Kunming Medical University,