Effects of Paroxetine and Sulpiride in the Treatment of Social Phobia in Young Women and Its Effects on Neurotransmitter and Sleep Structure

Changji WU; Liu YANG; Xinyu ZHANG

doi:10.12259/j.issn.2095-610X.S20231225

Volume 44 Issue 12

Dec. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(12): 159-164

Changji WU, Liu YANG, Xinyu ZHANG. Effects of Paroxetine and Sulpiride in the Treatment of Social Phobia in Young Women and Its Effects on Neurotransmitter and Sleep Structure[J]. Journal of Kunming Medical University, 2023, 44(12): 159-164. doi: 10.12259/j.issn.2095-610X.S20231225

Citation:

Changji WU, Liu YANG, Xinyu ZHANG. Effects of Paroxetine and Sulpiride in the Treatment of Social Phobia in Young Women and Its Effects on Neurotransmitter and Sleep Structure[J]. Journal of Kunming Medical University, 2023, 44(12): 159-164. doi: 10.12259/j.issn.2095-610X.S20231225

Citation:

Changji WU, Liu YANG, Xinyu ZHANG. Effects of Paroxetine and Sulpiride in the Treatment of Social Phobia in Young Women and Its Effects on Neurotransmitter and Sleep Structure[J]. Journal of Kunming Medical University, 2023, 44(12): 159-164. doi: 10.12259/j.issn.2095-610X.S20231225

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Effects of Paroxetine and Sulpiride in the Treatment of Social Phobia in Young Women and Its Effects on Neurotransmitter and Sleep Structure

doi: 10.12259/j.issn.2095-610X.S20231225

1.
Rehabilitation Department
2.
The 4th Psychiatry Department
3.
The 2nd Psychiatry Department，Shalingzi Hospital，Zhangjiakou City, Zhangjiakou Hebei 075000，China

Received Date: 2023-10-07
Available Online: 2023-12-19
Publish Date: 2023-12-25

Abstract

Abstract

Objective To explore the effects of paroxetine and sulpiride in the treatment of social phobia in young women and the effects on neurotransmitters and sleep structure. Methods 102 young female patients with social phobia in our hospital from February 2021 to February 2023 were selected and divided into 2 groups with 51 cases in each group by random number table method. The control group was treated with Paxil, and the study group was treated with Paxil + sulpiride for 3 months. Treatment effect, neurotransmitters [5-hydroxytryptamine（5-HT）, dopamine（DA）, gamma-aminobutyric acid（GABA）, myeloperoxidase（MPO）], sleep structure, social anxiety（LASA）, social fear（SPS） and social Results The research group's overall effective rate of treatment is 88.24%, which is higher than the control group's 70.59%（P<0.05）. 1 month and 3 months after treatment, the research group's serum levels of DA and MPO are lower than those of the control group, while the levels of 5-HT and GABA are higher than those of the control group（P<0.05）. 1 month and 3 months after treatment, the research group's sleep transition frequency and the proportion of stage I + stage II are lower than those of the control group, while the proportion of stage III + stage IV and REM stage are higher than those of the control group（P<0.05）. 1 month and 3 months after treatment, the research group's LASA, SPS, and SAFE scores are lower than those of the control group（P<0.05）; The incidence of adverse events in the research group is 13.73% compared to 9.80% in the control group, with no statistically significant difference（P>0.05）. Conclusion Paroxetine and sulpiride combined can improve the sleep structure of young women with social phobia, regulate serum neurotransmitter levels, alleviate social anxiety symptoms, improve social adaptability, and have a certain level of safety.
- Social phobia,
- Sulpride,
- Paroxetine,
- Sleep structure,
- Neurotransmitter

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References(22)

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