Research Progress of Indole in E. coli Biofilms on the Surface of Biomaterials

Danyan SU; Wentian TANG; Jinxu YANG; Hua LIU; Bangsheng LI; Yingding ZHAO; Yunchao HUANG

doi:10.12259/j.issn.2095-610X.S20231229

Volume 44 Issue 12

Dec. 2023

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Article Navigation > Journal of Kunming Medical University > 2023 > 44(12): 184-190

Danyan SU, Wentian TANG, Jinxu YANG, Hua LIU, Bangsheng LI, Yingding ZHAO, Yunchao HUANG. Research Progress of Indole in E. coli Biofilms on the Surface of Biomaterials[J]. Journal of Kunming Medical University, 2023, 44(12): 184-190. doi: 10.12259/j.issn.2095-610X.S20231229

Citation:

Danyan SU, Wentian TANG, Jinxu YANG, Hua LIU, Bangsheng LI, Yingding ZHAO, Yunchao HUANG. Research Progress of Indole in E. coli Biofilms on the Surface of Biomaterials[J]. Journal of Kunming Medical University, 2023, 44(12): 184-190. doi: 10.12259/j.issn.2095-610X.S20231229

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Research Progress of Indole in E. coli Biofilms on the Surface of Biomaterials

doi: 10.12259/j.issn.2095-610X.S20231229

Dept. of Thoracic Surgery，The 3rd Affilated Hospital of Kunming Medical University/Yunnan Cancer Hospital，Kunming Yunnan 650118，China

Received Date: 2023-06-13
Available Online: 2023-12-19
Publish Date: 2023-12-25

Abstract

Abstract

Escherichia coli is a highly adaptable opportunistic pathogen bacterium that can form biofilms on the surface of implants and generates persistent cells, leading to life-threatening infections that are difficult to treat with antibiotics alone. Therefore, there is a need for an effective E.coli biofilm inhibitor to combat this public health threat.Indole is a novel quorum-sensing signaling molecule of E. coli discovered in recent years, which is of great significance in regulating bacterial growth and biofilm formation, and is a potential target for future research on new anti-biofilm preparations. This article reviews the research progress on the formation of Escherichia coli biofilms, the microbial metabolism of indole and its regulation of Escherichia coli biofilm formation, in order to provide information for clinical treatment and drug development.
- Escherichia coli,
- Indole,
- Bacterial biofilm,
- Biomaterials,
- Implant infection

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References(61)

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