Research Progress of miRNA in Non-alcoholic Fatty Liver Disease

Hang CHEN; Qi CUI; Minshan HUANG; Jianjun LIU; Lanqing MA

doi:10.12259/j.issn.2095-610X.S20240101

Volume 45 Issue 1

Jan. 2024

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Hang CHEN, Qi CUI, Minshan HUANG, Jianjun LIU, Lanqing MA. Research Progress of miRNA in Non-alcoholic Fatty Liver Disease[J]. Journal of Kunming Medical University, 2024, 45(1): 1-7. doi: 10.12259/j.issn.2095-610X.S20240101

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Hang CHEN, Qi CUI, Minshan HUANG, Jianjun LIU, Lanqing MA. Research Progress of miRNA in Non-alcoholic Fatty Liver Disease[J]. Journal of Kunming Medical University, 2024, 45(1): 1-7. doi: 10.12259/j.issn.2095-610X.S20240101

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Research Progress of miRNA in Non-alcoholic Fatty Liver Disease

doi: 10.12259/j.issn.2095-610X.S20240101

Hang CHEN^{1, 2},
Qi CUI²,
Minshan HUANG^{1, 2},
Jianjun LIU²,
Lanqing MA^{1
,
,}

1.
Dept. of Gastroenterology，The 1st Affiliated Hospital of Kunming Medical University，Yunnan Institute of Digestive Disease，Yunnan Clinical Research Center for Digestive Diseases，Kunming Yunnan 650032
2.
Institute of Biomedical Engineering，Kunming Medical University，Kunming Yunnan 650500，China

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Corresponding author: 马岚青，医学博士，博士生导师，主任医师。现任昆明医科大学第一附属医院消化内科副主任（主持工作），昆明医科大学第一附属医院内科住院医师规范化培训基地主任，昆明医科大学第一附属医院内科教研室主任。美国加州大学圣地亚哥分校医学中心访问学者。中华医学会消化病学分会全国青年委员会委员；中华医学会消化病学分会肿瘤协助组委员；中国女医师协会消化病专业分会委员；云南省医院协会消化内科专业委员会主任委员；云南女医师协会消化病学分会主任委员；云南省医师协会消化医师分会副主任委员；云南省医学会消化病学分会委员；中国医师协会内镜医师培训学院导师。云南省中青年学术和技术带头人，云南省“万人计划”名医，云南省医学学科领军人才、带头人，云南省政府特殊津贴专家，国家自然科学基金评委。擅长消化内镜诊治技术如EMR/ESD/POEM/STER/EFTR、肝病、幽门螺杆菌感染性疾病及消化系统急、难、危重症诊治。主持4项国家自然科学基金及6项云南省自然科学基金项目，以第一作者及通讯作者发表SCI论文20余篇，总影响因子IF > 100，获国家级发明专利及新型实用专利5项，副主编及编委发表论著4部，获省级自然科学奖、科技进步奖一等奖、三等奖共5项。
Received Date: 2023-12-20
Available Online: 2024-01-10
Publish Date: 2024-01-25

Abstract

Abstract

Nonalcoholic fatty liver disease（NAFLD） is the most common chronic liver disease, with a global prevalence of approximately 30.05% to 32.4%. It is closely associated with various other diseases. In recent years, microRNAs（miRNAs） have played a crucial role as non-invasive biomarkers in understanding the pathogenesis and diagnosis of NAFLD. miRNAs play significant roles in both lipid metabolism and insulin resistance, exerting specific regulatory functions in the development and progression of NAFLD. miRNAs are small RNA molecules that regulate the gene expression and protein synthesis by controlling the transcription and translation of target genes. This article provides a comprehensive overview of the roles and mechanisms of miRNAs in lipid metabolism, insulin resistance, and the occurrence and development of NAFLD.
- Nonalcoholic fatty liver disease,
- miRNA,
- Insulin Resistance

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References(56)

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