Correlation Analysis of HLA-DM Gene Polymorphisms with Polio Vaccine-induced Antibody Response

Runan QI; Lei SHI; Shuyuan LIU; Jing LI; Li SHI

doi:10.12259/j.issn.2095-610X.S20240102

Volume 45 Issue 1

Jan. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(1): 8-14

Runan QI, Lei SHI, Shuyuan LIU, Jing LI, Li SHI. Correlation Analysis of HLA-DM Gene Polymorphisms with Polio Vaccine-induced Antibody Response[J]. Journal of Kunming Medical University, 2024, 45(1): 8-14. doi: 10.12259/j.issn.2095-610X.S20240102

Citation:

Runan QI, Lei SHI, Shuyuan LIU, Jing LI, Li SHI. Correlation Analysis of HLA-DM Gene Polymorphisms with Polio Vaccine-induced Antibody Response[J]. Journal of Kunming Medical University, 2024, 45(1): 8-14. doi: 10.12259/j.issn.2095-610X.S20240102

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Correlation Analysis of HLA-DM Gene Polymorphisms with Polio Vaccine-induced Antibody Response

doi: 10.12259/j.issn.2095-610X.S20240102

Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College，Kunming Yunnan 650118，China

Received Date: 2023-09-26
Publish Date: 2024-01-25

Abstract

Abstract

Objective To investigate the correlation between HLA-DM gene polymorphism and antibody response induced by poliomyelitis vaccine. Methods 355 healthy infants aged 2 to 3 months in Guangxi Zhuang Autonomous Region were selected as the study objects, and 10 SNPs of DMA exon 3 and DMB exon 2/3 were genotyped by Sanger sequencing. The correlation between DMA and DMB genes and poliomyelitis vaccine-induced antibody response was analyzed at allele, genotype and haplotype levels. Results In the type I antibody response induced by polio vaccine, the frequencies of DMA*01:02, DMB*01:01, DMB*01:01/DMB*01:01 and DMA*01:02-DMB*01:01 were higher in the non-seroconversion group than in the seroconversion group（P < 0.05）. In the polio type II antibody response, the frequencies of DMA*01:02, DMA*01:02/DMA*01:02, DMB*01:01/DMB*01:01 and DMA*01:02-DMB*01:01 were higher in the non-seroconversion group than in the seroconversion group（ P < 0.05）. Conclusion Alleles DMA*01:02 and DMB*01:01 may be associated with type I and type II antibody responses induced by poliomyelitis vaccine.
- HLA-DM,
- Gene polymorphism,
- Polio vaccine,
- Antibody response

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