Changes of Sex Hormone Levels in Infertile Population with Polycystic Ovary Syndrome after the Assisted Reproductive Technology Treatment

Limei HE; Xuemin FENG; Linjun LI; Ying CHEN; Zexing YANG

doi:10.12259/j.issn.2095-610X.S20240106

Volume 45 Issue 1

Jan. 2024

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2024 > 45(1): 73-77

Limei HE, Xuemin FENG, Linjun LI, Ying CHEN, Zexing YANG. Changes of Sex Hormone Levels in Infertile Population with Polycystic Ovary Syndrome after the Assisted Reproductive Technology Treatment[J]. Journal of Kunming Medical University, 2024, 45(1): 73-77. doi: 10.12259/j.issn.2095-610X.S20240106

Citation:

Limei HE, Xuemin FENG, Linjun LI, Ying CHEN, Zexing YANG. Changes of Sex Hormone Levels in Infertile Population with Polycystic Ovary Syndrome after the Assisted Reproductive Technology Treatment[J]. Journal of Kunming Medical University, 2024, 45(1): 73-77. doi: 10.12259/j.issn.2095-610X.S20240106

Citation:

Limei HE, Xuemin FENG, Linjun LI, Ying CHEN, Zexing YANG. Changes of Sex Hormone Levels in Infertile Population with Polycystic Ovary Syndrome after the Assisted Reproductive Technology Treatment[J]. Journal of Kunming Medical University, 2024, 45(1): 73-77. doi: 10.12259/j.issn.2095-610X.S20240106

PDF( 621 KB)

Changes of Sex Hormone Levels in Infertile Population with Polycystic Ovary Syndrome after the Assisted Reproductive Technology Treatment

doi: 10.12259/j.issn.2095-610X.S20240106

Limei HE^{1, 2
,
,},
Xuemin FENG¹,
Linjun LI²,
Ying CHEN^{1, 3},
Zexing YANG³

1.
School of Public Health，Kunming Medical University，Kunming Yunnan 650500
2.
Public Health Office，Shaoyang Central Hospital，Shaoyang Hunan 422000
3.
Dept. of Reproductive Genetics，The 1st Affiliated Hospital of Kunming Medical University， Kunming Yunnan 650032，China

Received Date: 2023-10-22
Publish Date: 2024-01-25

Abstract

Abstract

Objective To investigate the changes of sex hormone levels in polycystic ovary syndrome（PCOS） in infertile population after the assisted reproductive technology treatment, and to provide an evidence for the choice of the treatment. Methods The medical data of patients admitted to the First Affiliated Hospital of Kunming Medical University from January 2016 to June 2021 were collected and divided into PCOS group（103） and non-PCOS group（589） according to whether they were diagnosed with PCOS, and the sex hormone changes of the two groups were compared. Results The patients in PCOS group were younger and had the higher BMI, more sinus follicles, higher AMH value, and lower total Gn usage. The number of LH/FSH > 2 in PCOS group was higher than that in non-PCOS group（ P < 0.05）.After the treatment, LH in both groups decreased, FSH, E ₂ and （P < 0.05） increased; The difference of LH and E ₂ before and after the treatment in PCOS group was greater than that in non-PCOS group < 0.05）. Conclusion Compared with non-PCOS infertile patients, the changes of sex hormone indexes in PCOS infertile patients before and after the treatment were more obvious. In order to obtain the better clinical effect in patients with polycystic ovaries, it is recommended to pay attention to the changes of related sex hormone levels in the course of subsequent treatment, and choose a reasonable treatment plan.
- Polycystic ovary syndrome,
- Sex hormone,
- Treatment effect

FullText(HTML)

References(27)

References

[1]	Valdimarsdottir R,Wikstrom A K,Kallak T K,et al. Pregnancy outcome in women with polycystic ovary syndrome in relation to second-trimester testosterone levels[J]. Reprod Biomed Online,2021,42(1):217-225. doi: 10.1016/j.rbmo.2020.09.019
[2]	Gao L,Li M,Wang Y,et al. Overweight and high serum total cholesterol were risk factors for the outcome of IVF/ICSI cycles in PCOS patients and a PCOS-specific predictive model of live birth rate was established[J]. J Endocrinol Invest,2020,43(9):1221-1228. doi: 10.1007/s40618-020-01209-5
[3]	Wang N,Zhu Q,Ma M,et al. Comparison of a progestin-primed ovarian stimulation protocol with a flexible GnRH antagonist protocol in patients with polycystic ovary syndrome who are participating in an IVF programme: Study protocol for a randomised controlled trial[J]. BMJ Open,2020,10(12):e38153.
[4]	Teede H J,Misso M L,Costello M F,et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome[J]. Fertil Steril,2018,110(3):364-379. doi: 10.1016/j.fertnstert.2018.05.004
[5]	Scheinhardt M O,Lerman T,Knig I R,et al. Performance of prognostic modelling of high and low ovarian response to ovarian stimulation for IVF[J]. Hum Reprod,2018,33(8):1499-1505. doi: 10.1093/humrep/dey236
[6]	Coffler M S,Patel K,Dahan M H,et al. Evidence for abnormal granulosa cell responsiveness to follicle-stimulating hormone in women with polycystic ovary syndrome[J]. J Clin Endocrinol Metab,2003,88(4):1742-1747. doi: 10.1210/jc.2002-021280
[7]	Cao Y,Chen H,Zhao D,et al. The efficacy of Tung's acupuncture for sex hormones in polycystic ovary syndrome: A randomized controlled trial[J]. Complement Ther Med,2019,44(4):182-188.
[8]	高影,屈丽娜,于杜娇. 体外受精-胚胎移植中发生中重度卵巢过度刺激综合征患者的临床特征分析[J]. 中国妇幼保健,2021,36(22):5240-5242.
[9]	Sun B,Ma Y,Li L,et al. Factors associated with ovarian hyperstimulation syndrome (OHSS) severity in women with polycystic ovary syndrome undergoing IVF/ICSI[J]. Front Endocrinol (Lausanne),2020,11:615957.
[10]	Teede H J,Misso M L,Costello M F,et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome[J]. Hum Reprod,2018,33(9):1602-1618.
[11]	徐嗣亮,马翔,刘嘉茵,等. 多囊卵巢综合征患者心理状态评估和心理治疗[J]. 国际生殖健康/计划生育杂志,2023,42(6):481-486.
[12]	董正娇,张文悫,杨琳娜,等. 汉族多囊卵巢综合征(PCOS)患者生命质量状况及影响因素[J]. 昆明医科大学学报,2021,42(5):41-47.
[13]	Tsai Y H,Wang T W,Wei H J,et al. Dietary intake,glucose metabolism and sex hormones in women with polycystic ovary syndrome (PCOS) compared with women with non-PCOS-related infertility[J]. Br J Nutr,2013,109(12):2190-2198. doi: 10.1017/S0007114512004369
[14]	穆光宗. 中国的人口危机与应对[J]. 北京大学学报(哲学社会科学版),2019,56(5):69-76.
[15]	陈欢,洛若愚. 青春期多囊卵巢综合征的诊治进展[J]. 医学综述,2019,25(3):550-555.
[16]	黄会霞,郑巧荣,冯艳奇. 某高校女大学生月经现状的流行病学调查[J]. 中国卫生工程学,2020,19(6):954-955.
[17]	袁莹莹,赵君利. 多囊卵巢综合征流行病学特点[J]. 中国实用妇科与产科杂志,2019,35(3):261-264.
[18]	Chen X,Yang D,Mo Y,et al. Prevalence of polycystic ovary syndrome in unselected women from southern China[J]. Eur J Obstet Gynecol Reprod Biol,2008,139(1):59-64. doi: 10.1016/j.ejogrb.2007.12.018
[19]	康诠敏,金帆. 卵巢储备功能的影响因素及评估方法[J]. 发育医学电子杂志,2021,9(2):81-86.
[20]	闫益芬,晁晶,戴峻. 卵巢储备功能常用预测指标的临床价值[J]. 医学综述,2018,24(21):4318-4323.
[21]	杨金军,滕晓晶. 抗苗勒管激素硫酸脱氢表雄酮与性激素联合检测多囊卵巢综合征的应用价值[J]. 中国妇幼保健,2023,38(21):4195-4198.
[22]	De Leo V,Musacchio M C,Cappelli V,et al. Genetic,hormonal and metabolic aspects of PCOS: An update[J]. Reprod Biol Endocrinol,2016,14(1):38. doi: 10.1186/s12958-016-0173-x
[23]	Bildik G,Akin N,Seyhan A,et al. Luteal granulosa cells from natural cycles are more capable of maintaining their viability,steroidogenic activity and LH receptor expression than those of stimulated IVF cycles[J]. Hum Reprod,2019,34(2):345-355. doi: 10.1093/humrep/dey353
[24]	董梦姣,邱阳. 多囊卵巢综合征与心血管疾病的研究进展[J]. 中国医师杂志,2021,23(10):1592-1596. doi: 10.3760/cma.j.cn431274-20200808-01099
[25]	Yang Y,Liu B,Wu G,et al. Exploration of the value of progesterone and progesterone/estradiol ratio on the hCG trigger day in predicting pregnancy outcomes of PCOS patients undergoing IVF/ICSI: A retrospective cohort study[J]. Reprod Biol Endocrinol,2021,19(1):184. doi: 10.1186/s12958-021-00862-6
[26]	Labarta E,Rodriguez C. Progesterone use in assisted reproductive technology[J]. Best Pract Res Clin Obstet Gynaecol,2020,69(1):74-84.
[27]	安占英,党媛. 二甲双胍联合炔雌醇环丙孕酮片治疗多囊卵巢综合征的效果[J]. 贵州医药,2023,47(11):1741-1742. doi: 10.3969/j.issn.1000-744X.2023.11.036

Relative Articles(20)

Relative Articles

[1]	Zhenxing YUAN, Wenfei SUN, Weidong WANG. Relationship between hs-CRP，CCL2，CCL3 and Neonatal Bacterial Infection and Their Predictive Value for Efficacy. Journal of Kunming Medical University, 2024, 45(7): 119-125. doi: 10.12259/j.issn.2095-610X.S20240718
[2]	Xiaohui GU, Fenrong LV, Ju SUN, Yaping PENG, Dandan WAN. The Effectiveness of Liraglutide Combined with Metformin in Improving Glycolipid Metabolism and Hormonal Levels in Polycystic Ovary Syndrome: A Meta-Analysis. Journal of Kunming Medical University, 2024, 45(10): 1-10.
[3]	Xiaofeng ZHU, Guangping ZHOU, Laicang WANG, Houjun ZHOU, Xin GENG, Hualin YU, Jinghui LI, Peng BAI. Clinical Effect of Reoperation for Recurrent Glioma. Journal of Kunming Medical University, 2022, 43(9): 77-83. doi: 10.12259/j.issn.2095-610X.S20220920
[4]	Jin-hong LI, Hong WANG. Efficacy and Safety of Valsartan Amlodipine Tablets Combined with Alpha-lipoic Acid in the Treatment of Elderly Patients with Type 2 Diabetic Nephropathy Complicated with Hypertension. Journal of Kunming Medical University, 2021, 42(4): 53-56. doi: 10.12259/j.issn.2095-610X.S20210410
[5]	Zheng-jiao DONG, Wen-que ZHANG, Lin-na YANG, Xue-hui HUANG, Yi-yan ZHANG, Wen-yang ZHANG, Jing-jing ZHANG. Quality of Life and Its Influencing Factors in Han Nationality Patients with Polycystic Ovary Syndrome. Journal of Kunming Medical University, 2021, 42(5): 41-47. doi: 10.12259/j.issn.2095-610X.S20210508
[6]	Ting ZHAO, Hong-rong WANG, Zheng-jiao DONG, Mei-xiu GAO, Dong-yan REN, Tao YUAN. Clinical Analysis of Vaginal Microecology in Patients with Polycystic Ovary Syndrome. Journal of Kunming Medical University, 2021, 42(1): 106-109. doi: 10.12259/j.issn.2095-610X.S20210113
[7]	Ye Ji Ming , Gu Xue Zhong , Chu Yu Yan , Liu Yu , Ye Ji Yun . . Journal of Kunming Medical University, 2020, 41(03): 72-76.
[8]	Rong WAN, Ming-wu LI, Meng MA, Ming-hong LAI, Guang-mei Li. Efficacy of T-SPOT.TB in Treatment of Active Tuberculosis. Journal of Kunming Medical University, 2020, 41(12): 133-137. doi: 10.12259/j.issn.2095-610X.S20201237
[9]	Sun Yu Peng , Zhang Chun Qiang , Du Kai Li , He Shao Bo , Guo Pei Yu , Zhao Run Min . The Value of T-SPOT.TB in Evaluating Treatment Effect of Tuberculous Vertebral Osteomyelitis. Journal of Kunming Medical University, 2018, 39(06): 86-90.
[10]	Wang Rong Hua , Gu Ying , Fang Xia Ling . The Influence of Family Nursing Intervention on Treatment Effect and Quality of Life among Asthmatic Children. Journal of Kunming Medical University, 2018, 39(06): 144-148.
[11]	Qiu Mei . Unnecessity of Integrating Metabolic Indices into the Diagnosis of Polycystic Ovary Syndrome. Journal of Kunming Medical University,
[12]	Wang Xu , Guo Qing Hua , Zhu Xiao Pu , Zhu Xiao Yan , Yang Ming . Effect of Endoscopic Sinus Surgery on Paranasal Sinus Fungus Balls. Journal of Kunming Medical University, 2016, 37(12): 47-50.
[13]	Xiao Yi . The Clinical Effect of CDSP Treatment for Coronary Heart Disease. Journal of Kunming Medical University,
[14]	Tang Shi Cong . . Journal of Kunming Medical University,
[15]	Zhang Wen Yan . . Journal of Kunming Medical University,
[16]	Wang Yu . . Journal of Kunming Medical University,
[17]	Dai Shu Jing . . Journal of Kunming Medical University,
[18]	Lv Tao . . Journal of Kunming Medical University,
[19]	Shu Qian . . Journal of Kunming Medical University,
[20]	. Clinical Effects of Metformin Combined with Clomiphene in Treament of PCOS after Laparoscopic Ovarian Drilling. Journal of Kunming Medical University,