Risk Factors of Recurrence in Patients with Ischemic Stroke Treated with Aspirin Single Drug Antiplatelet Therapy

Qian LI; Puqiong FENG; Qin YAO; Hanmei CHEN; Ting ZHAO; Hui WU

doi:10.12259/j.issn.2095-610X.S20240113

Volume 45 Issue 1

Jan. 2024

Turn off MathJax

Article Contents

Abstract

References

Relative Articles

Article Navigation > Journal of Kunming Medical University > 2024 > 45(1): 78-82

Teng Yan . Effect of Hemoperfusion on Inflammation Factors in Patients with Sepsis[J]. Journal of Kunming Medical University, 2016, 37(05).

Citation:

Qian LI, Puqiong FENG, Qin YAO, Hanmei CHEN, Ting ZHAO, Hui WU. Risk Factors of Recurrence in Patients with Ischemic Stroke Treated with Aspirin Single Drug Antiplatelet Therapy[J]. Journal of Kunming Medical University, 2024, 45(1): 78-82. doi: 10.12259/j.issn.2095-610X.S20240113

Teng Yan . Effect of Hemoperfusion on Inflammation Factors in Patients with Sepsis[J]. Journal of Kunming Medical University, 2016, 37(05).

Citation:

PDF( 678 KB)

Risk Factors of Recurrence in Patients with Ischemic Stroke Treated with Aspirin Single Drug Antiplatelet Therapy

doi: 10.12259/j.issn.2095-610X.S20240113

1.
Dept. of Pharmacy，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032，China

Received Date: 2023-10-12
Available Online: 2024-01-05
Publish Date: 2024-01-25

Abstract

Abstract

Objective To investigate the risk factors of relapse in patients with ischemic stroke using aspirin for single drug antiplatelet therapy. Methods A retrospective analysis was conducted on 200 patients with mild and medium ischemic stroke after 12 months of single drug treatment with aspirin, and the patients were divided into non-recurrence group and recurrence group according to the recurrence of stroke. Univariate analysis and multivariate logistic regression model were used to explore whether the related indicators were risk factors for recurrence.The ROC curve was used to predict the critical value of risk factors. Results Univariate analysis showed that platelet count, Hcy level and the A allele at rs12041331 site of PEAR1 gene were statistically significant risk factors（P < 0.05）. Multifactor analysis showed that the independent risk factor for recurrence was homocysteine level [OR = 1.16（1.089-1.240）, P < 0.001）]. The critical value of ROC prediction was 8.35 μmol/L （sensitivity 0.847, specificity 0.532）. Conclusions The Hcy level, platelet count and A allele at rs12041331 site of PEAR1 gene are risk factors for recurrence in patients with ischemic stroke treated with aspirin for Single drug antiplatelet therapy.Hcy level is independent risk factor and can be used to predict the risk of recurrence.
- Ischemic stroke,
- Recurrence,
- PEAR1 gene,
- Homocysteine,
- Risk factor

FullText(HTML)

References(15)

References

[1]	中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组. 中国缺血性卒中和短暂性脑缺血发作二级预防指南2022[J]. 中华神经科杂志,2022,55(10):1071. doi: 10.3760/cma.j.cn113694-20220714-00548
[2]	诸葛瑞琪,刘梅林. 阿司匹林用于心血管疾病一级预防的进展[J]. 中国心血管杂志,2022,27(3):211.
[3]	Alberts M J,Bergman D L,Molner E,et al. Antiplatelet effect of aspirin in patients with cerebrovascular disease[J]. Stroke,2004,35(1):175. doi: 10.1161/01.STR.0000106763.46123.F6
[4]	Kasotakis G,Pipinos II,Lynch T G. Current evidence and clinical implications of aspirin resistance[J]. J Vasc Surg,2009,50(6):1500. doi: 10.1016/j.jvs.2009.06.023
[5]	Haines J M,Lee P M,Hegedus R M,et al. Investigation into the causes of aspirin resistance in healthy dogs[J]. J Vet Pharmacol Ther,2019,42(2):160. doi: 10.1111/jvp.12725
[6]	Meirhaeghe A,Cottel D,Cousin B,et al. Sex differences in stroke attack,incidence,and mortality rates in northern France[J]. J Stroke Cerebrovasc,2018,27(5):1368. doi: 10.1016/j.jstrokecerebrovasdis.2017.12.023
[7]	朱筱琦,陆学胜. 急性复发性脑梗死患者发生阿司匹林抵抗的相关性分析[J]. 中国药房,2016,27(9):1194.
[8]	孟文超,高美景,王立羽. 阿托伐他汀治疗老年缺血性卒中合并高脂血症患者的疗效与安全性[J]. 中国循证心血管医学杂志,2017,9(6):700.
[9]	赵楠楠,郑印,黄穹琼,等. 急性缺血性脑卒中早期预后不良的危险因素分析及预测模型构建[J]. 中国临床研究,2022,35(4):456.
[10]	Lewis J P,Riaz M,Xie S,et al. Genetic variation in PEAR1,cardiovascular outcomes and effects of Aspirin in a healthy elderly population[J]. Clin Pharmacol Ther,2020,108(6):1289. doi: 10.1002/cpt.1959
[11]	Faraday N,Yanek L R,Yang X P,et al. Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression[J]. Blood,2011,118(12):3367. doi: 10.1182/blood-2010-11-320788
[12]	李建设,孟轲,赵剑婷,等. PEAR1基因多态性对长期服用阿司匹林脑梗死患者复发的影响[J]. 中国实用神经疾病杂志,2017,20(20):26.
[13]	Lewis J P,Ryan K,O'Connell J R,et al. Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes[J]. Circ Cardiovasc Genet,2013,6(2):184. doi: 10.1161/CIRCGENETICS.111.964627
[14]	张鸥,刘洋,蒙航娟,等. 血浆同型半胱氨酸水平与脑卒中关系研究进展[J]. 中国公共卫生,2021,37(12):1840.
[15]	Shi Z,Liu S,Guan Y,et al. Changes in total homocysteine levels after acute stroke and recurrence of stroke[J]. Sci Rep-UK,2018,8(1):6993. doi: 10.1038/s41598-018-25398-5

Relative Articles(20)

Relative Articles

[1]	Yuyun YOU, Yunfei HONG, Xia ZHENG, Feifei LIU, Jinsong YIN. The Association between Serum Homocysteine to High-Density Lipoprotein Cholesterol Ratio and Premature Coronary Heart Disease. Journal of Kunming Medical University, 2025, 46(4): 1-7.
[2]	Yuyun YOU, Jinsong YIN, Yunfei HONG, Xia ZHENG, Feifei LIU. The Predictive Value of Changes in Serum Uric Acid and Homocysteine Levels in Patients with Stable Coronary Artery Disease. Journal of Kunming Medical University, 2025, 46(2): 95-102. doi: 10.12259/j.issn.2095-610X.S20250214
[3]	Yuting CHEN, Jun PU, Bin YAN, Renhua XIE. Prognostic Value of Pan-immune Inflammatory Values in Patients with Ischemic Stroke Treated with Intravascular Intervention Combined with Tirofiban. Journal of Kunming Medical University, 2025, 46(): 1-8.
[4]	Peilin CUI, Yuxia SONG, Xuejuan WANG. Predictive Value of Serum and Tissue miR-205 for Postoperative Recurrence of Ovarian-type Endometriosis. Journal of Kunming Medical University, 2024, 45(10): 105-110. doi: 10.12259/j.issn.2095-610X.S20241016
[5]	Xinyi MEN, Jing ZHAO, Yongchun SHEN, Hui JI, Xiuxia WANG. The Relationship between Peripheral Blood Immunoglobulin，Erythrocyte Sedimentation Rate，Homocysteine and the Degree of Central Nervous System Vasculitis in Children and Their Influence on Prognosis. Journal of Kunming Medical University, 2024, 45(12): 122-128. doi: 10.12259/j.issn.2095-610X.S20241217
[6]	Quanchang ZHANG, Qiaolian WU, Yu LIU, Xin ZHAO. The Impact of Laparoscopic and Open Total Mesocolon Resection on Platelet Activation，Incidence of Complications，and Tumor Recurrence in Colon Cancer Patients. Journal of Kunming Medical University, 2023, 44(9): 104-109. doi: 10.12259/j.issn.2095-610X.S20230919
[7]	Xiaofeng ZHU, Guangping ZHOU, Laicang WANG, Houjun ZHOU, Xin GENG, Hualin YU, Jinghui LI, Peng BAI. Clinical Effect of Reoperation for Recurrent Glioma. Journal of Kunming Medical University, 2022, 43(9): 77-83. doi: 10.12259/j.issn.2095-610X.S20220920
[8]	Li DENG, Hong-li FANG, Guang-qiong CAO, Hui-fang GAO. Research on the Relationship between Serum Homocysteine Level and Blood Lipids in Healthy People. Journal of Kunming Medical University, 2021, 42(1): 157-160. doi: 10.12259/j.issn.2095-610X.S20210107
[9]	Guang-qiong CAO, Li DENG, Hong-li FANG, Hui-fang GAO, Shuai Kui. A Longitudinal Cohort Study on the Effects of Homocysteine on Blood Pressure, Blood Glucose and Blood Lipid in Physical Examination Population in Kunming. Journal of Kunming Medical University, 2021, 42(6): 76-81. doi: 10.12259/j.issn.2095-610X.S20210603
[10]	Ming-xiong ZHANG, Xiao-wen ZHANG. The Risk Factor Analysis for Recurrence in the Treatment of Choledochojejunostomy for Hepatolithiasis. Journal of Kunming Medical University, 2021, 42(9): 76-82. doi: 10.12259/j.issn.2095-610X.S20210937
[11]	Hou Yun He , Zhang Hao Xin , Wang Yi Yu , Su Yan Mei , Gu Dan Shan , Lin Shao Fang , Yang Shi Kun , Li Shu De . Regulatory Mechanism of Ginsenoside Rg1 on Homocysteine in NAFLD Model. Journal of Kunming Medical University, 2018, 39(04): 27-33.
[12]	Zhang Mei . The Effect of High Homocysteine on Blood Glucose Control in Type 2 Diabetic Patients. Journal of Kunming Medical University,
[13]	Li Hong . . Journal of Kunming Medical University,
[14]	Liu Shi Jie . . Journal of Kunming Medical University,
[15]	Wang Zhi Min . . Journal of Kunming Medical University,
[16]	Chai Yan Jing . . Journal of Kunming Medical University,
[17]	Tao Hong Fei . . Journal of Kunming Medical University,
[18]	Wang Ya Nan . . Journal of Kunming Medical University,
[19]	. TRB3 Mediates Homocysteine-induced Inhibition of Endothelial Cells Proliferation. Journal of Kunming Medical University,
[20]	Guo Li Min . . Journal of Kunming Medical University,

Supplements(0)

Cited By

Cited by

Periodical cited type(7)

1.	孙宇，张晨雪，闫骥，武雪亮，张建锋，王立坤. 基因检测及超声灰度值预测结直肠癌肝转移患者消融治疗预后及影响因素分析. 河北医科大学学报. 2025(01): 99-107 .
2.	杨晓娟，郭志武，马红丽，杨友锋，王浩，王奕江，李振勇. 人KRAS基因突变检测试剂盒的性能评价. 医疗装备. 2025(01): 27-31 .
3.	杨楠，何乐，李振珺，刘凤磊，向奇，常守凤. 结直肠癌不同转移部位的KRAS、NRAS、BRAF、PIK3CA基因突变特点及其与预后的关系. 医学研究杂志. 2025(01): 48-53+115 .
4.	张紫玉，刘畅，杨小英，周英，权伟，俸婷婷，刘雄伟. 苗药肺筋草调控NF-κB/JAK途径改善大鼠急性肺损伤的作用机制研究. 药物评价研究. 2024(11): 2548-2558 .
5.	雷全国，王佳丽，黄小刚，谢增丁. 同期手术与分期手术治疗同时性结直肠癌肝转移的临床效果比较. 大医生. 2023(17): 66-69 .
6.	谭晶，高波. KRAS、NRAS及BRAF基因突变状态对结直肠癌术后辅助化疗患者预后的影响. 河南医学研究. 2023(22): 4132-4135 .
7.	杜劲，邱瑾，蔡文平，王文娟，庞小燕. KRAS、NRAS、BRAF、PIK3CA、NTRK联合检测与结直肠癌预后的相关性分析. 智慧健康. 2023(27): 113-116 .