Clinical and Pathological Characteristics of Extrapleural Solitary Fibrous Tumor

Ying LIU; Shujie SONG; Lin WU

doi:10.12259/j.issn.2095-610X.S20240117

Volume 45 Issue 1

Jan. 2024

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2024 > 45(1): 100-106

Ying LIU, Shujie SONG, Lin WU. Clinical and Pathological Characteristics of Extrapleural Solitary Fibrous Tumor[J]. Journal of Kunming Medical University, 2024, 45(1): 100-106. doi: 10.12259/j.issn.2095-610X.S20240117

Citation:

Ying LIU, Shujie SONG, Lin WU. Clinical and Pathological Characteristics of Extrapleural Solitary Fibrous Tumor[J]. Journal of Kunming Medical University, 2024, 45(1): 100-106. doi: 10.12259/j.issn.2095-610X.S20240117

Citation:

PDF( 2271 KB)

Clinical and Pathological Characteristics of Extrapleural Solitary Fibrous Tumor

doi: 10.12259/j.issn.2095-610X.S20240117

1.
Dept. of Pathology，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118，China

Received Date: 2023-11-08
Available Online: 2024-01-09
Publish Date: 2024-01-25

Abstract

Abstract

Objective To investigate the clinical and pathological characteristics of the extrapleural solitary fibrous tumor and the relevant differential diagnosis. Methods HE and immunohistochemical staining were performed on 26 samples of isolated fibrous tumors outside the pleura, and a comprehensive analysis was conducted based on the clinical and imaging data. Results The histological morphology of isolated fibrous tumors was diverse, with typical cases showing the irregular arrangement of oval or spindle shaped cells. In the stroma, thick collagen bands, antler like blood vessels, and peritubular transparent degeneration could be seen. The immunohistochemical staining demonstrated that the positive rates of STAT-6、CD34、Bcl-2、CD99、SMA were 96.2%、92.3%、92.3%、76.9% and 26.9%, respectively. Conclusion SFT commonly occurs in the pleura and can also occur in other areas. Its histological characteristics and immunohistochemical phenotype help to clarify the diagnosis. However, when it occurs in uncommon anatomical sites, it is necessary to carefully and meticulously distinguish and comprehensively judge the clinical prognosis of key diseases that need to be distinguished or excluded..
- Extrapleural solitary fibrous tumor,
- Histological morphology,
- Biological behaviour,
- Clinical prognosis

FullText(HTML)

References(51)

References

[1]	Joon H C,Jae Y R. The 2020 WHO Classification of tumors of soft tissue: Selected changes and new entities[J]. Adv Anat Pathol,2021,28(1):44-58.
[2]	Papathanassiou Z G,Alberghini M,Picci P,et al. Solitary fibrous tumors of the soft tissues: Imaging features with histopathologic correlations[J]. Clin Sarcoma Res,2013,3(1):1. doi: 10.1186/2045-3329-3-1
[3]	Erdag G,Qureshi H S,Patterson J W,et al. Solitary fibrous tumors of the skin: A clinicopathologic study of 10 cases and review of the literature[J]. J Cutan Pathol,2007,34(11):844-850. doi: 10.1111/j.1600-0560.2006.00728.x
[4]	Liu Y Q,Yue J Q. Intramural solitary fibrous tumor of the ileum: A case report and review of the literature[J]. J Cancer Res Ther,2013,9(4):724-726. doi: 10.4103/0973-1482.126469
[5]	Ronchi A,La Mantia E,Gigantino V,et al. A rare case of malignant solitary fibrous tumor in prostate with review of the literature[J]. Diagn Pathol,2017,12(1):50. doi: 10.1186/s13000-017-0640-5
[6]	Dungarwalla M M,Barrett A W,Gulati A. Solitary fibrous tumour of the tongue: A series of four cases[J]. J Laryngol Otol,2017,131(9):838-841. doi: 10.1017/S0022215117001396
[7]	Papi G,Corrado S,Uberti E D,et al. Solitary fibrous tumor of the thyroid gland[J]. Thyroid,2007,17(2):119-126. doi: 10.1089/thy.2005.0202
[8]	Bauer J L,Miklos A Z,Thompson L D. Parotid gland solitary fibrous tumor: A case report and clinicopathologic review of 22 cases from the literature[J]. Head Neck Pathol,2012,6(1):21-31. doi: 10.1007/s12105-011-0305-8
[9]	Tanaka K,Yano H,Hayashi H,et al. Total resection combined with osteotomy is more effective for orbital solitary fibrous tumor excision: A report of three cases[J]. Int Ophthalmol,2018,38(1):345-351. doi: 10.1007/s10792-016-0421-2
[10]	Insabato L,Siano M,Somma A,et al. Extrapleural solitary fibrous tumor: A clinicopathologic study of 19 cases[J]. Int J Surg Pathol,2009,17(3):250-254. doi: 10.1177/1066896909333779
[11]	Chang S K,Yoon D Y,Choi C S,et al. CT,MR,and angiography findings of a solitary fibrous tumor of the larynx: A case report[J]. Korean J Radiol,2008,9(6):568-571. doi: 10.3348/kjr.2008.9.6.568
[12]	Shim Y S,Choi S J,Kim H S,et al. Solitary fibrous tumor of the trachea: CT findings with a pathological correlation[J]. Korean J Radiol,2008,9(3):286-289. doi: 10.3348/kjr.2008.9.3.286
[13]	Placide N,Robert S. Solitary fibrous tumor of the vagina: A case report with review of the literature[J]. Int J Surg Pathol,2012,20(1):101-104. doi: 10.1177/1066896911413577
[14]	Bouvier C,M é tellus P,De Paula A M,et al. Solitary fibrous tumors and hemangiopericytomas of the meninges: Overlapping pathological features and common prognostic factors suggest the same spectrum of tumors[J]. Brain Pathol,2012,22(4):511-521. doi: 10.1111/j.1750-3639.2011.00552.x
[15]	Fine S W,McCarthy D M,Chan T Y,et al. Malignant solitary fibrous tumor of the kidney: Report of a case and comprehensive review of the literature[J]. Arch Pathol Lab Med,2006,130(6):857-861. doi: 10.5858/2006-130-857-MSFTOT
[16]	Li X M,Reng J,Zhou P,et al. Solitary fibrous tumors in abdomen and pelvis: Imaging characteristics and radiologic-pathologic correlation[J]. World J Gastroenterol,2014,20(17):5066-5073. doi: 10.3748/wjg.v20.i17.5066
[17]	Zhang H,Yu S,Wang W,et al. Primary mesenchymal tumors of the pancreas in a single center over 15 years[J]. Oncol Lett,2016,12(5):4027-4034. doi: 10.3892/ol.2016.5155
[18]	Feng L H,Dong H,Zhu Y Y,et al. An update on primary hepatic solitary fibrous tumor: An examination of the clinical and pathological features of four case studies and a literature review[J]. Pathol Res Pract,2015,211(12):911-917. doi: 10.1016/j.prp.2015.09.004
[19]	Rao N,Colby T V,Falconieri G,et al. Intrapulmonary solitary fibrous tumors: Clinicopathologic and immunohistochemical study of 24 cases[J]. Am J Surg Pathol,2013,37(2):155-166. doi: 10.1097/PAS.0b013e31826a92f5
[20]	Oike N,Kawashima H,Ogose A,et al. A malignant solitary fibrous tumour arising from the first lumbar vertebra and mimicking an osteosarcoma: A case report[J]. World J Surg Oncol,2017,15(1):100. doi: 10.1186/s12957-017-1161-0
[21]	Cranshaw I M,Gikas P D,Fisher C,et al. Clinical outcomes of extra-thoracic solitary fibrous tumours[J]. Eur J Surg Oncol,2009,35(9):994-998. doi: 10.1016/j.ejso.2009.02.015
[22]	Lee J Y,Park S E,Shin S J,et al. Solitary fibrous tumor with myxoid stromal change[J]. Am J Dermatopathol,2015,37(7):570-573. doi: 10.1097/DAD.0000000000000154
[23]	Guillou L,Gebhard S,Coindre J M. Lipomatous hemangiopericytoma: A fat-containing variant of solitary fibrous tumor? Clinicopathologic,immunohistochemical,and ultrastructural analysis of a series in favor of a unifying concept[J]. Hum Pathol,2000,31(9):1108-1115. doi: 10.1053/hupa.2000.9777
[24]	Jing H B,Meng Q D,Tai Y H. Lipomatous hemangiopericytoma of the stomach: A case report and a review of literature[J]. World J Gastroenterol,2011,17(43):4835-4838. doi: 10.3748/wjg.v17.i43.4835
[25]	Barazani Y,Tareen B. Rare case of paratesticular solitary fibrous tumour (lipomatous hemangiopericytoma)[J]. Can Urol Assoc J,2012,6(3):E131-133. doi: 10.5489/cuaj.11092
[26]	Davies P E,Davis G J,Dodd T,et al. Orbital lipomatous haemangiopericytoma: An unusual variant[J]. Clin Exp Ophthalmol,2002,30(4):281-283. doi: 10.1046/j.1442-9071.2002.00542.x
[27]	Dei Tos A P,Seregard S,Calonje E,et al. Giant cell angiofibroma. A distinctive orbital tumor in adults[J]. Am J Surg Pathol,1995,19(11):1286-1293. doi: 10.1097/00000478-199511000-00009
[28]	Guillou L,Gebhard S,Coindre J M. Orbital and extraorbital giant cell angiofibroma: A giant cell-rich variant of solitary fibrous tumor? Clinicopathologic and immunohistochemical analysis of a series in favor of a unifying concept[J]. Am J Surg Pathol,2000,24(7):971-979. doi: 10.1097/00000478-200007000-00008
[29]	Sigel J E,Fisher C,Vogt D,et al. Giant cell angiofibroma of the inguinal region[J]. Ann Diagn Pathol,2000,4(4):240-244. doi: 10.1053/adpa.2000.8129
[30]	Mosquera J M,Fletcher C D. Expanding the spectrum of malignant progression in solitary fibrous tumors: A study of 8 cases with a discrete anaplastic component-is this dedifferentiated SFT?[J]. Am J Surg Pathol,2009,33(9):1314-1321. doi: 10.1097/PAS.0b013e3181a6cd33
[31]	Thway K,Hayes A,Ieremia E,et al. Heterologous osteosarcomatous and rhabdomyosarcomatous elements in dedifferentiated solitary fibrous tumor: Further support for the concept of dedifferentiation in solitary fibrous tumor[J]. Ann Diagn Pathol,2013,17(5):457-463. doi: 10.1016/j.anndiagpath.2012.08.006
[32]	Miettinen M. Immunohistochemistry of soft tissue tumours - review with emphasis on 10 markers[J]. Histopathology,2014,64(1):101-118. doi: 10.1111/his.12298
[33]	Schweizer L,Koelsche C,Sahm F,et al. Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein[J]. Acta Neuropathol,2013,125(5):651-658. doi: 10.1007/s00401-013-1117-6
[34]	Mohajeri A,Tayebwa J,Collin A,et al. Comprehensive genetic analysis identifies a pathognomonic NAB2/STAT6 fusion gene,nonrandom secondary genomic imbalances,and a characteristic gene expression profile in solitary fibrous tumor[J]. Genes Chromosomes Cancer,2013,52(10):873-886. doi: 10.1002/gcc.22083
[35]	Vivero M,Doyle L A,Fletcher C D,et al. GRIA2 is a novel diagnostic marker for solitary fibrous tumour identified through gene expression profiling[J]. Histopathology,2014,65(1):71-80. doi: 10.1111/his.12377
[36]	Demicco E G,Harms P W,Patel R M,et al. Extensive survey of STAT6 expression in a large series of mesenchymal tumors[J]. Am J Clin Pathol,2015,143(5):672-682. doi: 10.1309/AJCPN25NJTOUNPNF
[37]	Ouladan S,Trautmann M,Orouji E,et al. Differential diagnosis of solitary fibrous tumors: A study of 454 soft tissue tumors indicating the diagnostic value of nuclear STAT6 relocation and ALDH1 expression combined with in situ proximity ligation assay[J]. Int J Oncol,2015,46(6):2595-2605. doi: 10.3892/ijo.2015.2975
[38]	Lecoutere E,Creytens D. Multifocal cytokeratin expression in pleural and abdominal malignant solitary fibrous tumors: An unusual diagnostic pitfall[J]. Virchows Arch,2015,467(1):119-121. doi: 10.1007/s00428-015-1768-x
[39]	Doyle L A,Vivero M,Fletcher C D,et al. Nuclear expression of STAT6 distinguishes solitary fibrous tumor from histologic mimics[J]. Mod Pathol,2014,27(3):390-395. doi: 10.1038/modpathol.2013.164
[40]	Thway K,Jordan S,Fisher C,et al. Updates in the approach to intrathoracic sarcomas[J]. Histopathology,2015,67(6):755-770. doi: 10.1111/his.12771
[41]	Musyoki F N,Nahal A,Powell T I. Solitary fibrous tumor: An update on the spectrum of extrapleural manifestations[J]. Skeletal Radiol,2012,41(1):5-13. doi: 10.1007/s00256-010-1032-z
[42]	Fukasawa Y,Takada A,Tateno M,et al. Solitary fibrous tumor of the pleura causing recurrent hypoglycemia by secretion of insulin-like growth factor II[J]. Pathol Int,1998,48(1):47-52. doi: 10.1111/j.1440-1827.1998.tb03827.x
[43]	Steigen S E,Schaeffer D F,West R B,et al. Expression of insulin-like growth factor 2 in mesenchymal neoplasms[J]. Mod Pathol,2009,22(7):914-921. doi: 10.1038/modpathol.2009.48
[44]	Demicco E G,Park M S,Araujo D M,et al. Solitary fibrous tumor: A clinicopathological study of 110 cases and proposed risk assessment model[J]. Mod Pathol,2012,25(9):1298-1306. doi: 10.1038/modpathol.2012.83
[45]	Cardillo G,Carbone L,Carleo F,et al. Solitary fibrous tumors of the pleura: An analysis of 110 patients treated in a single institution[J]. Ann Thorac Surg,2009,88(5):1632-1637. doi: 10.1016/j.athoracsur.2009.07.026
[46]	Ito H,Fukuda M,Imamura Y,et al. A malignant solitary fibrous tumor in the retroperitoneum[J]. Int J Clin Oncol,2008,13(2):173-175. doi: 10.1007/s10147-007-0712-8
[47]	Bishop A J,Zagars G K,Demicco E G,et al. Soft tissue solitary fibrous tumor: Combined surgery and radiation therapy results in excellent local control[J]. Am J Clin Oncol,2018,41(1):81-85. doi: 10.1097/COC.0000000000000218
[48]	Gold J S,Antonescu C R,Hajdu C,et al. Clinicopathologic correlates of solitary fibrous tumors[J]. Cancer,2002,94(4):1057-1068. doi: 10.1002/cncr.10328
[49]	Moran C A,Suster S,Koss M N. The spectrum of histologic growth patterns in benign and malignant fibrous tumors of the pleura[J]. Semin Diagn Pathol,1992,9(2):169-180.
[50]	Briselli M,Mark E J,Dickersin G R. Solitary fibrous tumors of the pleura: Eight new cases and review of 360 cases in the literature[J]. Cancer,1981,47(11):2678-2689. doi: 10.1002/1097-0142(19810601)47:11<2678::AID-CNCR2820471126>3.0.CO;2-9
[51]	Vallat-Decouvelaere A V,Dry S M,Fletcher C D. Atypical and malignant solitary fibrous tumors in extrathoracic locations: Evidence of their comparability to intra-thoracic tumors[J]. Am J Surg Pathol,1998,22(12):1501-1511. doi: 10.1097/00000478-199812000-00007

Relative Articles(20)

Relative Articles

[1]	Binbin MA, Shaoxiong ZHANG, Yongli GAO. Bioinformatics-based Investigation of the Prognostic Value of ESCRT-related Genes in Osteosarcoma Assessment. Journal of Kunming Medical University, 2025, 46(4): 1-10.
[2]	Lanbo FU, Chaolie RUAN, Changxu CHEN, Yu GAO, Xiaolin BAO, Bochuan LIU, Jian ZHOU, Weidong LI. Domestication and Biological Characteristics of a Vero Cell Line in Suspension Culture. Journal of Kunming Medical University, 2024, 45(6): 7-14. doi: 10.12259/j.issn.2095-610X.S20240602
[3]	Wangxun SHEN, Yinyu YANG, Canwei LI, Jinrong YANG, Sijing WU, Huajun ZHAO, Xiaoyu TUO. Expression and Clinical Significance of ROR1 in Different Histologic Types of Invasive Lung Adenocarcinoma. Journal of Kunming Medical University, 2024, 45(5): 60-65. doi: 10.12259/j.issn.2095-610X.S20240509
[4]	Maimaitizunong Rezeye, Xiujuan LI, Ling LIU, Hui LI. Effects of Ferroptosis Inhibitor KIF20A on Biological Behavior and Ferroptosis of Esophageal Carcinoma Cells. Journal of Kunming Medical University, 2024, 45(2): 49-56. doi: 10.12259/j.issn.2095-610X.S20240207
[5]	Yi FENG, Xiaofeng WANG, Ximin BAI, Sheng YAO, Juntao DANG, Yunjie ZHAO, Bing CAI. miR-149-5p Regulates Malignant Biological Behavior of Glioma Cells Through MSH5/WNT Signaling Pathway. Journal of Kunming Medical University, 2023, 44(8): 59-70. doi: 10.12259/j.issn.2095-610X.S20230823
[6]	Jin-rong YANG, Kun WU, Bo NIE, Zhen-xin HE, Yu-yu YANG, Jie SUN, Yun ZENG. Clinical Features of Adult HPS and the Correlation between Cytokine Levels and Prognosis. Journal of Kunming Medical University, 2021, 42(12): 51-58. doi: 10.12259/j.issn.2095-610X.S20211220
[7]	Yu-hang QUAN, Zhong-hui WANG, Shan-shan LI, Guang-shun LIU. Sevoflurane Inhibits Xuanwei Lung Cancer Cell Line XWLC-05. Journal of Kunming Medical University, 2021, 42(12): 1-5. doi: 10.12259/j.issn.2095-610X.S20211202
[8]	Ma Guo Yu , Xiong Qing , Jiang Guo Qing , Yang Jia Tian , Mu Yun Zhen . . Journal of Kunming Medical University, 2020, 41(07): 30-37.
[9]	Chen Xiao Xing , Di Guang , Ge Jia Yun , Wei Dong , Shi Zhi Tian , Guo Zhi Tang , Wang Tao , Zhao Song Ling , Wang Lian Min , Wang Lin . . Journal of Kunming Medical University, 2020, 41(08): 1-7.
[10]	Xiang Ying Ying , Yu Hong Bin , Zhou Jing , Yang Xiang Hong , Song Fei , Wei Yun Lin , Ji Xiu Ling . . Journal of Kunming Medical University, 2020, 41(05): 46-51.
[11]	Li Xiao Tao , Wang Hai Feng , Wang Jian Song . . Journal of Kunming Medical University, 2019, 40(12): 130-134.
[12]	Li Jia . . Journal of Kunming Medical University,
[13]	Liu Li Xin . . Journal of Kunming Medical University,
[14]	Yang Man . . Journal of Kunming Medical University,
[15]	Lu Xin . . Journal of Kunming Medical University,
[16]	Gu Ya Lv . . Journal of Kunming Medical University,
[17]	Yang Yin Feng . . Journal of Kunming Medical University,
[18]	Wang Feng . . Journal of Kunming Medical University,
[19]	. Influence of Hypoxia on Hepatoma Carcinoma Cell Line SMMC7721 in Vitro. Journal of Kunming Medical University,
[20]	Wang Peng . . Journal of Kunming Medical University,