The Relationship between Urinary NGAL and Flow-mediated Vasodilation in Prehypertension

Da PENG; Aijun ZHANG

doi:10.12259/j.issn.2095-610X.S20240121

Volume 45 Issue 1

Jan. 2024

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Da PENG, Aijun ZHANG. The Relationship between Urinary NGAL and Flow-mediated Vasodilation in Prehypertension[J]. Journal of Kunming Medical University, 2024, 45(1): 127-132. doi: 10.12259/j.issn.2095-610X.S20240121

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Da PENG, Aijun ZHANG. The Relationship between Urinary NGAL and Flow-mediated Vasodilation in Prehypertension[J]. Journal of Kunming Medical University, 2024, 45(1): 127-132. doi: 10.12259/j.issn.2095-610X.S20240121

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The Relationship between Urinary NGAL and Flow-mediated Vasodilation in Prehypertension

doi: 10.12259/j.issn.2095-610X.S20240121

Da PENG^{1, 2},
Aijun ZHANG^{1
,
,}

1.
Dept.of Cardiology，Wuchang Hospital Affiliated to Wuhan University of Science and Technology，Wuhan Hubei 430063
2.
The 8nd Clinical School，Wuhan University of Science and Technology，Wuhan Hubei 430081，China

Received Date: 2023-11-01
Publish Date: 2024-01-25

Abstract

Abstract

Objective To explore the correlation between the urinary neutrophil gelatinase-associated lipid carrier protein（NGAL） and Brachial artery flow-mediated vasodilation（FMD） in Prehypertension. Methods 156 patients with Prehypertension found to have the normal high blood pressure during a health examination at the Luo Shi Road Community Health Service Center of Wuchang Hospital in Wuhan from September 2022 to September 2023 were included and divided into the normal endothelial function group and the endothelial dysfunction group with 89 cases and 67 cases respectively in each group according to whether the FMD was above 10%. The sex, age, smoking history, height, weight, SBP, DBP, FBG, Scr, eGFR, BUN, UA, Hcy, urine NGAL, FMD and other indicators were collected. The correlation between FMD and NGAL in prehypertension was analyzed by using independent samples t-test, Pearson linear correlation, multiple linear regression, binary logistic regression, and receiver operator characteristic（ROC） curves. Results There were no significant differences in gender, smoking history, SBP, FBG, TG, LDL-c, TC, BUN, Scr, UA, eGFR and Hcy（all P > 0.05）.The age, BMI, DBP, HDL-c, and urine NGAL levels in the endothelial dysfunction group were significantly higher than those in the normal endothelial function group（ P < 0.05）. Pearson linear correlation analysis showed that urine NGAL levels were negative correlated with FMD（ r = -0.632 P < 0.05）. Multiple linear regression analysis: NGAL, DBP significantly affected FMD（all P < 0.05）. NGAL and diastolic blood pressure were independent risk factors for FMD. The area under the curve of ROC curve analysis was 0.813, 0.895 and 0.906 respectively for urinary NGAL, DBP and urinary NGAL combined with DBP. DBP combined with urinary NGAL had the higher diagnostic efficacy. Conclusion Urinary NGAL and DBP are associated with the endothelial dysfunction, and urinary NGAL is expected to be a new biomarker for evaluating the vascular endothelial function loss and a target for the intervention of prehypertension
- Urinary NGAL,
- Flow-mediated vasodilation,
- Prehypertension,
- Hypertension

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