Correlation of <i>KRAS</i> Gene 3′ UTR Polymorphisms with Cervical Cancer and Cervical Intraepithelial Neoplasia in Chinese Han Population in Yunnan Province

Ni GUO; Cheng ZHANG; Chao HONG; Weipeng LIU; Yufeng YAO; Zhiling YAN

doi:10.12259/j.issn.2095-610X.S20240203

Volume 45 Issue 2

Feb. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(2): 14-22

Ni GUO, Cheng ZHANG, Chao HONG, Weipeng LIU, Yufeng YAO, Zhiling YAN. Correlation of KRAS Gene 3′ UTR Polymorphisms with Cervical Cancer and Cervical Intraepithelial Neoplasia in Chinese Han Population in Yunnan Province[J]. Journal of Kunming Medical University, 2024, 45(2): 14-22. doi: 10.12259/j.issn.2095-610X.S20240203

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Ni GUO, Cheng ZHANG, Chao HONG, Weipeng LIU, Yufeng YAO, Zhiling YAN. Correlation of KRAS Gene 3′ UTR Polymorphisms with Cervical Cancer and Cervical Intraepithelial Neoplasia in Chinese Han Population in Yunnan Province[J]. Journal of Kunming Medical University, 2024, 45(2): 14-22. doi: 10.12259/j.issn.2095-610X.S20240203

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Correlation of KRAS Gene 3′ UTR Polymorphisms with Cervical Cancer and Cervical Intraepithelial Neoplasia in Chinese Han Population in Yunnan Province

doi: 10.12259/j.issn.2095-610X.S20240203

1.
Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College，Kunming Yunnan 650118
2.
Dept. of Gynecology，The People’s Hospital of Zhenxiong County，Kunming Yunnan 657200
3.
Dept. of Gynecology，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118，China

Received Date: 2024-01-16
Available Online: 2024-02-27
Publish Date: 2024-02-25

Abstract

Abstract

Objective To investigate the correlation between rs712 and rs7973450 located at the 3′ UTR region of the KRAS gene and the risk of cervical cancer （CC） and cervical intraepithelial neoplasia （CIN） in Chinese Han population in Yunnan province. Methods A total of 2405 individuals （461 subjects with CIN, 961 subjects with CC and 983 healthy controls） were enrolled. The SNPs were genotyped used TaqMan assay and the correlation of these SNPs with CIN and CC was analyzed. Results The A allele of rs7973450 might be a protective factor for the occurrence of CIN （P = 0.004, OR= 0.651, 95%CI 0.487 ～ 0.871） and CC （P = 7.00 × 10^-4, OR= 0.667, 95%CI 0.529 ～ 0.844）. There was no significant difference in allelic and genotypic distribution of rs712 among CIN, CC and Control groups （P > 0.017）. The haplotype assay showed thatrs712A-rs7973450G was associated with increased risk of CIN （P = 4.00 × 10^-4; OR= 1.714, 95%CI 1.269 ～ 2.314） and CC （P = 3.84 × 10^-5, OR= 1.667, 95%CI 1.305 ～ 2.131）. While haplotype rs712A-rs7973450A was associated with a lower risk of CC （P = 0.012, OR= 0.790, 95%CI 0.658 ～ 0.950）. Conclusion The A allele of rs7973450 in 3′ UTR of KRAS gene might be the protective factor for the occurrence of CIN and CC in a Chinese Han population in Yunnan province.
- KRAS,
- Single nucleotide polymorphism,
- Cervical cancer,
- Cervical intraepithelial neoplasia,
- Han population in Yunnan

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References(35)

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