Comparison of Four Methods in the Diagnosis of Bone Tuberculosis

Xiaoqin LI; Zhiqiang MA; Nan TIAN; Wei CHEN; Caixin LI; Min ZHOU

doi:10.12259/j.issn.2095-610X.S20240218

Volume 45 Issue 2

Feb. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(2): 131-135

Xiaoqin LI, Zhiqiang MA, Nan TIAN, Wei CHEN, Caixin LI, Min ZHOU. Comparison of Four Methods in the Diagnosis of Bone Tuberculosis[J]. Journal of Kunming Medical University, 2024, 45(2): 131-135. doi: 10.12259/j.issn.2095-610X.S20240218

Citation:

Xiaoqin LI, Zhiqiang MA, Nan TIAN, Wei CHEN, Caixin LI, Min ZHOU. Comparison of Four Methods in the Diagnosis of Bone Tuberculosis[J]. Journal of Kunming Medical University, 2024, 45(2): 131-135. doi: 10.12259/j.issn.2095-610X.S20240218

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Comparison of Four Methods in the Diagnosis of Bone Tuberculosis

doi: 10.12259/j.issn.2095-610X.S20240218

Xiaoqin LI¹,
Zhiqiang MA¹,
Nan TIAN²,
Wei CHEN¹,
Caixin LI^{1
,
,},
Min ZHOU^{1
,
,}

1.
Dept. of Laboratory Infectious Disease，The Third People’s Hospital of Kunming，Yunnan Clinical Medical Center for Infectious Diseases，Kunming Yunnan 650031
2.
School of Public Health，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2023-12-19
Available Online: 2024-02-26
Publish Date: 2024-02-25

Abstract

Abstract

Objective To compare the diagnostic value of smear acid-fast staining, TB-DNA, X-pert MTB/RIF and culture of Mycobacterium tuberculosis. Methods Four methods were used to detect the perifocal pus of the patients with bone destruction in orthopaedics department within one year, and the results were analyzed statistically, the indexes included sensitivity, specificity, positive predictive value and negative predictive value. Results The sensitivity, specificity, positive predictive value, negative predictive value, and Youden index were 31.75%, 100.00%, 100.00%, 53.74% and 0.32 respectively. TB-DNA had a sensitivity of 88.89%, a specificity of 98.00%, a positive predictive value of 98.25%, a negative predictive value of 87.50%, and a Youden Index of 0.87. Xpert MTB/Rif had a sensitivity of 95.23%, a specificity of 68.00%, and a positive predictive value of 78.95%, the negative predictive value was 91.90%, the Youden index was 0.63. The sensitivity, the specificity, the positive predictive value, the negative predictive value and the Youden index were 41.27%, 100.00%, 100.00%, 57.47% and 0.41 respectively, （χ² = 77.354, P <0.005） . Conclusion Among the four methods, TB-DNA has a good Sensitivity and specificity, Xpert mtbrif has a good sensitivity, TB-DNA and Xpert mtbrif ha a good authenticity, and both positive and negative predictive values are high, it has good value in the diagnosis of bone tuberculosis.
- Smear acid-fast staining,
- TB-DNA,
- Xpert/MTB/RIF,
- Culture of mycobacterium,
- Tuberculosis bone

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References(20)

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