Effect of Nicorandil on Inflammation-related Markers after PCI Intervention in Patients with Acute Coronary Syndromes

Xiaodong ZHANG; Nan NIU; Ying LIU; Jiajie MEI; Zhaohong GENG; Hongyan WANG

doi:10.12259/j.issn.2095-610X.S20240219

Volume 45 Issue 2

Feb. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(2): 136-140

Xiaodong ZHANG, Nan NIU, Ying LIU, Jiajie MEI, Zhaohong GENG, Hongyan WANG. Effect of Nicorandil on Inflammation-related Markers after PCI Intervention in Patients with Acute Coronary Syndromes[J]. Journal of Kunming Medical University, 2024, 45(2): 136-140. doi: 10.12259/j.issn.2095-610X.S20240219

Citation:

Xiaodong ZHANG, Nan NIU, Ying LIU, Jiajie MEI, Zhaohong GENG, Hongyan WANG. Effect of Nicorandil on Inflammation-related Markers after PCI Intervention in Patients with Acute Coronary Syndromes[J]. Journal of Kunming Medical University, 2024, 45(2): 136-140. doi: 10.12259/j.issn.2095-610X.S20240219

Citation:

Xiaodong ZHANG, Nan NIU, Ying LIU, Jiajie MEI, Zhaohong GENG, Hongyan WANG. Effect of Nicorandil on Inflammation-related Markers after PCI Intervention in Patients with Acute Coronary Syndromes[J]. Journal of Kunming Medical University, 2024, 45(2): 136-140. doi: 10.12259/j.issn.2095-610X.S20240219

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Effect of Nicorandil on Inflammation-related Markers after PCI Intervention in Patients with Acute Coronary Syndromes

doi: 10.12259/j.issn.2095-610X.S20240219

Xiaodong ZHANG^{1, 2},
Nan NIU^{1
,
,},
Ying LIU^{2
,
,},
Jiajie MEI¹,
Zhaohong GENG¹,
Hongyan WANG¹

1.
Dept. of Cardiology，The 2nd Hospital of Dalian Medical University 116023
2.
Dept. of Heart Failure and Structural Heart Disease，The 1st Hospital of Dalian Medical University，Dalian Liaoning 116011，China

Received Date: 2023-11-11
Publish Date: 2024-02-25

Abstract

Abstract

Objective To investigate the effects of treatment with nicorandil after Percutaneous Coronary Intervention （PCI） in patients with Acute Coronary Syndrome （ACS） on inflammation-related markers, and to assess its effects on vascular endothelial function. Methods Sixty-six ACS patients who underwent PCI in the Department of Cardiovascular Medicine of the Second Affiliated Hospital of Dalian Medical University from August 2022 to January 2023 were used as the study sample, and were divided into the control group and the experimental group according to the method of completely randomized design, with 33 cases in each group. The control group was treated with conventional therapy, and the experimental group was treated with nicorandil. Inflammatory indexes, homocysteine （Hcy） and adverse reactions in serum were compared between the two groups. Results After nicorandil treatment, the levels of postoperative inflammation-related factors in the control group were higher than that in the experimental group, and the difference was statistically significant （P < 0.05）; The levels of Hcy after nicorandil treatment were lower than that in the control group, and the difference was statistically significant （ P < 0.05）; and the rate of adverse reactions in the experimental group was higher than that in the control group, and there was no statistical difference （ P > 0.05）. Conclusion Nicorandil application in elderly ACS patients after PCI has a definite efficacy, can optimize the vascular-related inflammatory indexes, reduce homocysteine levels to improve coronary vascular endothelial function, and is suitable for further promotion.
- Acute coronary syndrome,
- Inflammatory indicators,
- Nicorandil

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