Effects of Different Virulence Types of Helicobacter Pylori on Gastric Micro-environment

Xiaoqing ZHAO; Jiaxin XIAO; Yong LIN; Jianfeng ZHANG; Wenhui WANG; Wenjie ZHANG

doi:10.12259/j.issn.2095-610X.S20240221

Volume 45 Issue 2

Feb. 2024

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Xiaoqing ZHAO, Jiaxin XIAO, Yong LIN, Jianfeng ZHANG, Wenhui WANG, Wenjie ZHANG. Effects of Different Virulence Types of Helicobacter Pylori on Gastric Micro-environment[J]. Journal of Kunming Medical University, 2024, 45(2): 148-152. doi: 10.12259/j.issn.2095-610X.S20240221

Citation:

Xiaoqing ZHAO, Jiaxin XIAO, Yong LIN, Jianfeng ZHANG, Wenhui WANG, Wenjie ZHANG. Effects of Different Virulence Types of Helicobacter Pylori on Gastric Micro-environment[J]. Journal of Kunming Medical University, 2024, 45(2): 148-152. doi: 10.12259/j.issn.2095-610X.S20240221

Citation:

Xiaoqing ZHAO, Jiaxin XIAO, Yong LIN, Jianfeng ZHANG, Wenhui WANG, Wenjie ZHANG. Effects of Different Virulence Types of Helicobacter Pylori on Gastric Micro-environment[J]. Journal of Kunming Medical University, 2024, 45(2): 148-152. doi: 10.12259/j.issn.2095-610X.S20240221

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Effects of Different Virulence Types of Helicobacter Pylori on Gastric Micro-environment

doi: 10.12259/j.issn.2095-610X.S20240221

Dept. of Gastroenterology，Guangdong Provincial Hospital of Chinese Medicine，Zhuhai Guangdong 519000，China

Received Date: 2023-06-01
Publish Date: 2024-02-25

Abstract

Abstract

Objective To observe the effects of different virulence types of Helicobacter pylori on pepsin and inflammatory factors. Methods 110 patients admitted from December 2021 to March 2023 were collected and divided into HP positive group（n=79） and HP negative group（n=31） according to 13 carbon breath test results. The HP positive group was divided into type I group（n=52）, type II group（n=11） and undetermined group（n=16） according to the Helicobacter pylori antibody typing. The HP negative group was selected and divided into blank control group（n=12）. Gastric juice pH value, sodion（Na⁺）, potassium（K⁺）, chloridion（Cl^-）, IL-6, IL-8, gastrin 17（G-17）, pepsinogen Ⅰ（PG Ⅰ） and pepsinogen Ⅱ（PG Ⅱ） were detected in all patients. Results There was no difference in pH, Na⁺, Cl^-, K⁺ between Hp positive group and Hp negative group（P > 0.05）. The content of Cl- in HP-positive group was lower than that in HP-negative group（ P < 0.05）. The levels of IL-6, IL-8, G-17, PG Ⅰ and PG Ⅱ in HP-positive group were significantly higher than those in HP-negative group（ P < 0.05）. There was no significant difference in pH, Na ⁺ and K⁺ between type I group and type II group, undetermined group and blank control group（P > 0.05）. The content of Cl ^- in type I group and undetermined group was lower than that in blank control group（P < 0.05）. The levels of IL-6, IL-8 and PG Ⅰ in type I group were higher than those in type II group, undetermined group and blank control group（ P < 0.05）. There was a significant difference in PG Ⅱ between the blank control group and the other groups（ P < 0.05）. There was no difference in G-17 content between type I group and undetermined group（ P > 0.05）. The level of G-17 in type I group was higher than that in type II group and blank control group（ P < 0.05）. Conclusion Type I Hp infection may cause gastric mucosal injury by increasing the expression of IL-6, IL-8 and G-17, and then lead to abnormal digestive function.
- Helicobacter pylori,
- Pepsinogen,
- IL-6,
- IL-8,
- Gastrin 17,
- PG Ⅰ,
- PG Ⅱ

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