Association of Polymorphisms in the 3' UTR of Genes in the ERK1/2 Signaling Pathway with Non-small Cell Lung Cancer

Chao HONG; Xudong XIANG; Yingfu LI; Yang CAO; Xueya CHEN; Shuai LI; Anhao XING; Mu LIN; Qianli MA

doi:10.12259/j.issn.2095-610X.S20240302

Volume 45 Issue 3

Mar. 2024

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Chao HONG, Xudong XIANG, Yingfu LI, Yang CAO, Xueya CHEN, Shuai LI, Anhao XING, Mu LIN, Qianli MA. Association of Polymorphisms in the 3' UTR of Genes in the ERK1/2 Signaling Pathway with Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2024, 45(3): 7-17. doi: 10.12259/j.issn.2095-610X.S20240302

Citation:

Chao HONG, Xudong XIANG, Yingfu LI, Yang CAO, Xueya CHEN, Shuai LI, Anhao XING, Mu LIN, Qianli MA. Association of Polymorphisms in the 3' UTR of Genes in the ERK1/2 Signaling Pathway with Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2024, 45(3): 7-17. doi: 10.12259/j.issn.2095-610X.S20240302

Citation:

Chao HONG, Xudong XIANG, Yingfu LI, Yang CAO, Xueya CHEN, Shuai LI, Anhao XING, Mu LIN, Qianli MA. Association of Polymorphisms in the 3' UTR of Genes in the ERK1/2 Signaling Pathway with Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2024, 45(3): 7-17. doi: 10.12259/j.issn.2095-610X.S20240302

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Association of Polymorphisms in the 3' UTR of Genes in the ERK1/2 Signaling Pathway with Non-small Cell Lung Cancer

doi: 10.12259/j.issn.2095-610X.S20240302

Chao HONG¹,
Xudong XIANG²,
Yingfu LI³,
Yang CAO²,
Xueya CHEN¹,
Shuai LI²,
Anhao XING²,
Mu LIN^{4
,
,},
Qianli MA^{2
,
,}

1.
Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College，Kunming Yunnan 650118
2.
Dept. of Thoracic Surgery，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118
3.
Dept. of Cadre Medicine，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650032
4.
Dept. of Laboratory Medicine，2nd People’s Hospital of Baoshan，Baoshan Yunnan 678000，China

Received Date: 2023-12-14
Available Online: 2024-03-12
Publish Date: 2024-03-30

Abstract

Abstract

Objective To investigate the association between four single nucleotide polymorphisms（SNP）（rs9340 in MAPK1, rs14804 in NRAS, rs712 and rs7973450 in KRAS） in the 3'UTR of ERK1/2 signaling pathway-related genes and non-small cell lung cancer（NSCLC）. Methods A total of 478 NSCLC patients and 480 healthy controls were enrolled in this study. Four SNPs were genotyped by using TaqMan assays. The association between the four SNPs and NSCLC was analyzed. Results The distribution frequency difference of the allele of rs9340 was statistically significant between the control group and the non-small cell squamous cell carcinoma（SCC） group（P = 0.009）, suggesting that the G allele of rs9340 may be a protective factor for non-small cell lung squamous cell carcinoma（OR = 0.67, 95%CI: 0.50～0.91）. In addition, in the < 50 years age group, the distribution frequency difference of the allele of rs9340 was statistically significant between the control group and the NSCLC group（P = 5.07 × 10^-4）, indicating that the G allele of rs9340 may be a protective factor for NSCLC（OR = 0.46, 95%CI: 0.29～0.72）. Conclusion The SNP rs9340 in MAPK1 may be associated with the risk of NSCLC.
- Non-small cell lung cancer,
- ERK1/2 signaling pathway,
- SNP,
- 3'UTR,
- MAPK1

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References(48)

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