Relationship between TGF-β/Smads Signaling Pathway and Cognitive Dysfunction in Patients with Aneurysmal Subarachnoid Hemorrhage

Yi HUANG; Yongjian HUANG; Ling MAI; Ting LUO

doi:10.12259/j.issn.2095-610X.S20240319

Volume 45 Issue 3

Mar. 2024

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Yi HUANG, Yongjian HUANG, Ling MAI, Ting LUO. Relationship between TGF-β/Smads Signaling Pathway and Cognitive Dysfunction in Patients with Aneurysmal Subarachnoid Hemorrhage[J]. Journal of Kunming Medical University, 2024, 45(3): 127-132. doi: 10.12259/j.issn.2095-610X.S20240319

Citation:

Yi HUANG, Yongjian HUANG, Ling MAI, Ting LUO. Relationship between TGF-β/Smads Signaling Pathway and Cognitive Dysfunction in Patients with Aneurysmal Subarachnoid Hemorrhage[J]. Journal of Kunming Medical University, 2024, 45(3): 127-132. doi: 10.12259/j.issn.2095-610X.S20240319

Citation:

Yi HUANG, Yongjian HUANG, Ling MAI, Ting LUO. Relationship between TGF-β/Smads Signaling Pathway and Cognitive Dysfunction in Patients with Aneurysmal Subarachnoid Hemorrhage[J]. Journal of Kunming Medical University, 2024, 45(3): 127-132. doi: 10.12259/j.issn.2095-610X.S20240319

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Relationship between TGF-β/Smads Signaling Pathway and Cognitive Dysfunction in Patients with Aneurysmal Subarachnoid Hemorrhage

doi: 10.12259/j.issn.2095-610X.S20240319

1.
Dept. of Neurosurgery
2.
Dept. of Surgical Anesthesiology
3.
Supply Room，The People’s Hospital of Chongzuo，Chongzuo Guangxi 532200，China

Received Date: 2023-12-05
Available Online: 2024-03-11
Publish Date: 2024-03-25

Abstract

Abstract

Objective To investigate the relationship between factors related to the transforming growth factor β（TGF-β）/Aerine-threonine kinase receptors（Smads） signaling pathway and cognitive dysfunction in peripheral blood of patients with aneurysmal subarachnoid hemorrhage（aSAH）. Methods The clinical data of 100 patients with aSAH admitted to Chongzuo City People's Hospital from October 2018 to March 2022 were retrospectively selected and grouped according to the patients' Montreal Cognitive Assessment Scale（MoCA） scores, including 54 cases with cognitive dysfunction and 46 cases without cognitive dysfunction. The clinical data, peripheral blood TGF-β, Smad1, Smad3, and Smad7 mRNA expression levels of the two groups were compared. The relationship between pathway-related factors and cognitive dysfunction in patients with aSAH was analyzed in a multifactorial manner. The predictive value of pathway-related factors for cognitive dysfunction in aSAH patients was assessed using the receiver operating characteristic（ROC） curve. Results Peripheral blood TGF-β, Smad1, Smad3, and Smad7 mRNA expression levels were higher in the cognitively impaired group than in the group without cognitive impairment（P < 0.05）. Multifactorial showed that pathway-related factors were significantly associated with cognitive impairment in patients with aSAH（P < 0.05）. The ROC showed that the area under the curve（AUC） of pathway-related factors jointly predicted cognitive dysfunction in patients with aSAH was superior to that predicted alone（P < 0.05）. Conclusion The high expression of factors related to the TGF-β/Smads signaling pathway in the peripheral blood of aSAH patients suggests that this pathway may be associated with cognitive dysfunction in patients.
- Aneurysmal subarachnoid hemorrhage,
- TGF-β/Smads signaling pathway,
- Cognitive dysfunction

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References(25)

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