Volume 45 Issue 3
Mar.  2024
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Article Navigation >  Journal of Kunming Medical University  > 2024  >  45(3): 133-140
Xiaoyue ZHOU, Ting YU. The Application of Narrative Education in the Clinical Teaching of Nursing Interns[J]. Journal of Kunming Medical University, 2024, 45(5): 190-194. doi: 10.12259/j.issn.2095-610X.S20240529
Citation: Hongyan WEI, Yuanzhen WANG, Lixian CHANG, Huan MU, Chunyun LIU, Li LIU. Risk Prediction of SBP in Patients with Primary Liver Cancer Complicated with Ascites[J]. Journal of Kunming Medical University, 2024, 45(3): 133-140. doi: 10.12259/j.issn.2095-610X.S20240320
shu

Risk Prediction of SBP in Patients with Primary Liver Cancer Complicated with Ascites

doi: 10.12259/j.issn.2095-610X.S20240320
  • 1.

    Dept. of Hepatology and Immunology，Third People’s Hospital of Kunming，Yunnan Clinical Center for Infectious Diseases，Kunming Yunnan 650041

  • 2.

    School of Public Health，Dali University，Dali Yunnan 671000，China

  • Received Date: 2023-12-05
  • Publish Date: 2024-03-25
    Abstract
  •   Objective   To explore the influencing factors of spontaneous bacterial peritonitis in patients with primary liver cancer complicated with ascites and establish a prediction model.   Methods   A total of 292 patients with primary liver cancer complicated with ascites who were hospitalized for the first time in the Third People’ s Hospital of Kunming from January 2012 to December 2021 were selected as the study objects. General data, etiological indicators, serological indicators and complications of these subjects were collected. Then they were divided into the infection group （n = 114） and the control group （n = 178） according to whether spontaneous bacterial peritonitis （SBP） was complicated. Univariate and multivariate logistic regression were used to analyze the influencing factors of SBP in patients with primary liver cancer complicated with ascites. Finally, ROC curves were constructed to more intuitively represent the individual and combined predictive value of these targets.   Results   Among 292 hepatocellular carcinoma patients with ascites, there were 235 males （80.48%） and 57 females （19.52%）, among which 114 patients with SBP were in the infection group and 178 patients without SBP were in the control group. The results of univariate analysis showed that compared with the control group, the levels of WBC, neutrophils, prothrombin time, total bilirubin, albumin, CD3 , CD4 , CD8 , CD4/CD8 ratio, CD19 procalcitonin, serum amyloid A, hypersensitive C-reactive protein, sodium , chlorine , alcohol consumption, shock, hepatorenal syndrome, hepatic encephalopathy, massive ascites in the infection group had statistically significant difference （P < 0.05）. Multi-factor analysis revealed that CD8, CD4/CD8 ratio were protective factors for SBP in patients with liver cancer ascites, CD19, procalcitonin , serum amyloid A, and massive ascites were risk factors for SBP in patients with ascites. ROC curve construction showed that serum amyloid A, CD8, CD4/CD8 ratio, CD19, procalcitonin, massive ascites area under curve （AUC） of massive ascites were 0.724, 0.637, 0.653, 0.820, 0.705, 0.686, respectively.   Conclusion   CD8, CD4/CD8 ratio, CD19, procalcitonin, serum amyloid A, and a large volume of ascites are significant factors contributing to the development of spontaneous bacterial peritonitis （SBP） in patients with hepatocellular carcinoma ascites. The predictive value of combination is substantial, demonstrating a level of accuracy in forecasting SBP occurrence
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