Research Progress of Iron Death in Cardiomyopathy

Wei LI; Lihong JIANG; Lijing MA; Rui CHEN; Tongshuo YANG

doi:10.12259/j.issn.2095-610X.S20240327

Volume 45 Issue 3

Mar. 2024

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Wei LI, Lihong JIANG, Lijing MA, Rui CHEN, Tongshuo YANG. Research Progress of Iron Death in Cardiomyopathy[J]. Journal of Kunming Medical University, 2024, 45(3): 180-185. doi: 10.12259/j.issn.2095-610X.S20240327

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Wei LI, Lihong JIANG, Lijing MA, Rui CHEN, Tongshuo YANG. Research Progress of Iron Death in Cardiomyopathy[J]. Journal of Kunming Medical University, 2024, 45(3): 180-185. doi: 10.12259/j.issn.2095-610X.S20240327

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Research Progress of Iron Death in Cardiomyopathy

doi: 10.12259/j.issn.2095-610X.S20240327

1.
Dept. of Cardiac Surgery，Yan'an Hospital Affiliated to Kunming Medical University，Kunming Yunnan 650051
2.
Dept. of Endocrinology and Metabolism，The 1st People’s Hospital of Yunnan Province，Kunming Yunnan 650034，China

Received Date: 2023-04-04
Available Online: 2024-03-06
Publish Date: 2024-03-30

Abstract

Abstract

Cardiomyopathy is a group of heterogeneous myocardial diseases with a variety of specific phenotypes that can lead to cardiovascular death or progressive heart failure in severe cases. Because of the severity and complexity of these diseases, the search for new regulatory mechanisms to prevent and treat cardiomyopathy is particularly urgent. Iron death is a form of programmed cell death that differs from other forms of iron dependence and is characterized by the accumulation of iron-dependent lipid peroxides. Studies have shown that iron death can be involved in the occurrence and progression of cardiomyopathy through different signaling pathways. Therefore, targeted regulation of iron death is a new strategy to prevent cardiomyopathy. In this paper, the mechanism of iron death and its important role in cardiomyopathy were reviewed to find the potential relationship between iron death and cardiomyopathy and provide more ideas for the treatment of various cardiomyopathies in the future.
- Cardiomyopathy,
- Ferroptosis,
- Cell death,
- Iron metabolism

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References(41)

References

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