Association between Myeloperoxidase-463G/A Gene Polymorphism and Essential Hypertension in Yi Nationality

Chengya MA; Jiang YANG; Xi CHEN; Xi XU; Pixuan YIN; Xin SHU; Hongyu PENG; Zhixiang FAN; Li LONG

doi:10.12259/j.issn.2095-610X.S20240408

Volume 45 Issue 4

Apr. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(4): 57-61

Chengya MA, Jiang YANG, Xi CHEN, Xi XU, Pixuan YIN, Xin SHU, Hongyu PENG, Zhixiang FAN, Li LONG. Association between Myeloperoxidase-463G/A Gene Polymorphism and Essential Hypertension in Yi Nationality[J]. Journal of Kunming Medical University, 2024, 45(4): 57-61. doi: 10.12259/j.issn.2095-610X.S20240408

Citation:

Chengya MA, Jiang YANG, Xi CHEN, Xi XU, Pixuan YIN, Xin SHU, Hongyu PENG, Zhixiang FAN, Li LONG. Association between Myeloperoxidase-463G/A Gene Polymorphism and Essential Hypertension in Yi Nationality[J]. Journal of Kunming Medical University, 2024, 45(4): 57-61. doi: 10.12259/j.issn.2095-610X.S20240408

Citation:

Chengya MA, Jiang YANG, Xi CHEN, Xi XU, Pixuan YIN, Xin SHU, Hongyu PENG, Zhixiang FAN, Li LONG. Association between Myeloperoxidase-463G/A Gene Polymorphism and Essential Hypertension in Yi Nationality[J]. Journal of Kunming Medical University, 2024, 45(4): 57-61. doi: 10.12259/j.issn.2095-610X.S20240408

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Association between Myeloperoxidase-463G/A Gene Polymorphism and Essential Hypertension in Yi Nationality

doi: 10.12259/j.issn.2095-610X.S20240408

1.
School of Basic Medicine
2.
Dept. of Cell Biology and Medical Genetics，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2023-09-23
Available Online: 2023-12-22
Publish Date: 2024-04-29

Abstract

Abstract

Objective To study the correlation between the polymorphism of myeloperoxidase-463G/A gene and essential hypertension of Yi nationality in Yunnan Province. Methods The PCR-RFLP technique was used to detect the MPO-463G/A gene polymorphism in 86 Yi hypertensive patients and 100 normal Yi people in Shuanghe Township and Yunnan Province collected by the First Affiliated Hospital of Kunming Medical University from January 2007 to November 2008. The frequencies of the GG, GA, and AA genotypes and the G and A allele frequencies were calculated, followed by association analysis. Results The genotype frequencies of MPO gene-463G/A polymorphism in EH group and control group GG were 66.28%, 52.00%, GA+AA were 33.72%, 48.00%, respectively. The frequencies of allele G were 79.65% and 69.50%, and the frequencies of allele A were 20.35% and 30.50%, respectively. There were statistically significant differences in genotype frequency and gene frequency between the two groups（P < 0.05）. The genotype frequencies of GG and GA+AA were 74.50% and 49.30% in female EH group and 25.50% and 50.70% in femal control group. The allele frequencies of G and A were 85.50% and 69.00% in EH group and 14.50% and 31.00% in control group. The differences were statistically significant（P < 0.05）. The frequency of A gene in female EH group was significantly lower than that in female control group. There was no significant difference in genotype frequency and gene frequency between EH group and control group in Yi male（P > 0.05）. Conclusion MPO gene-463G/A polymorphism is related to essential hypertension in Yunnan Yi women and is a susceptibility gene for hypertension in Yi women. The expression of the A allele at this locus has a protective effect during the development of EH in Yi women.
- Myeloperoxidase,
- Essential hypertension,
- The Yi nationality,
- Gene polymorphism

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