Efficacy and Safety of Jingangteng Capsules Combined with Antimicrobial Drugs in the Treatment of Chronic Pelvic Inflammatory Disease: A Meta-analysis

Xing LIU; Weixian LI; Yan WU; Xuejiao WU; Xiaodie YAO; Jie CHEN; Lingjun SHEN; Hao FAN

doi:10.12259/j.issn.2095-610X.S20240412

Volume 45 Issue 4

Apr. 2024

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2024 > 45(4): 81-91

Xing LIU, Weixian LI, Yan WU, Xuejiao WU, Xiaodie YAO, Jie CHEN, Lingjun SHEN, Hao FAN. Efficacy and Safety of Jingangteng Capsules Combined with Antimicrobial Drugs in the Treatment of Chronic Pelvic Inflammatory Disease: A Meta-analysis[J]. Journal of Kunming Medical University, 2024, 45(4): 81-91. doi: 10.12259/j.issn.2095-610X.S20240412

Citation:

Xing LIU, Weixian LI, Yan WU, Xuejiao WU, Xiaodie YAO, Jie CHEN, Lingjun SHEN, Hao FAN. Efficacy and Safety of Jingangteng Capsules Combined with Antimicrobial Drugs in the Treatment of Chronic Pelvic Inflammatory Disease: A Meta-analysis[J]. Journal of Kunming Medical University, 2024, 45(4): 81-91. doi: 10.12259/j.issn.2095-610X.S20240412

Citation:

Xing LIU, Weixian LI, Yan WU, Xuejiao WU, Xiaodie YAO, Jie CHEN, Lingjun SHEN, Hao FAN. Efficacy and Safety of Jingangteng Capsules Combined with Antimicrobial Drugs in the Treatment of Chronic Pelvic Inflammatory Disease: A Meta-analysis[J]. Journal of Kunming Medical University, 2024, 45(4): 81-91. doi: 10.12259/j.issn.2095-610X.S20240412

PDF( 2311 KB)

Efficacy and Safety of Jingangteng Capsules Combined with Antimicrobial Drugs in the Treatment of Chronic Pelvic Inflammatory Disease: A Meta-analysis

doi: 10.12259/j.issn.2095-610X.S20240412

Xing LIU¹,
Weixian LI¹,
Yan WU¹,
Xuejiao WU²,
Xiaodie YAO²,
Jie CHEN¹,
Lingjun SHEN^{1
,
,},
Hao FAN^{2
,
,}

1.
Yunnan Clinical Center for Infectious Diseases/Dept. of Pharmacy，The 3rd People’s Hospital of Kunming，Kunming Yunnan 650041
2.
School of Pharmaceutical Sciences，Dali University，Dali Yunnan 671000，China

Received Date: 2023-12-19
Available Online: 2024-04-02
Publish Date: 2024-04-29

Abstract

Abstract

Objective To systematically evaluate the efficacy and safety of Jingangteng capsule combined with antibiotics in the treatment of chronic pelvic inflammatory disease. Methods Randomized controlled trials （RCTs） of Jingangteng capsule combined with antibiotics in the treatment of chronic pelvic inflammatory disease were searched from domestic and foreign databases. RevMan 5.4 software was used for Meta-analysis. Results Twenty-four studies of RCTs were finally included, with a total sample size of 2, 441 cases. Meta-analysis showed that the combination of antimicrobial drugs with Jingangteng capsule significantly increased the overall clinical effectiveness rate of patients with chronic pelvic inflammatory disease [RR=1.19, 95%CI （1.15, 1.23）, P < 0.001]. It also reduced the incidence of adverse events compared with treatment with antimicrobial drugs alone [RR=0.70, 95%CI （0.51, 0.95）, P < 0.05]. In addition, the treatment of chronic pelvic inflammatory disease with Jingangteng capsule combined with antimicrobial drugs improved in promoting the recovery of inflammatory factor, and lymphocytes compared with antimicrobial drug therapy alone （P < 0.05）, and also effectively shortened the symptomatic remission time and improved the hemorheological indexes （P < 0.05）. Conclusion Jingangteng capsule combined with antibacterial agents has good efficacy and safety in the treatment of chronic pelvic inflammatory disease, but in view of the quality of research evidence, it should be applied according to the actual clinical situation.
- Jingangteng capsule,
- Chronic pelvic inflammatory,
- Systematic evaluation,
- Meta-analysis

FullText(HTML)

References(41)

References

[1]	曹俊岩,刘小古,曾莉,等. 支原体及衣原体感染对慢性盆腔炎病情及阴道菌群的影响[J]. 中华医院感染学杂志,2023,33(13):2037-2041.
[2]	吴威,朱文丽,柴淑慧,等. 女性盆腔炎外周血补体C3、C4及MCP-1因子的表达[J]. 中华医院感染学杂志,2022,32(14):2183-2186.
[3]	张艳红,尹宁,王彩虹,等. 盆炎清方治疗慢性盆腔炎疗效及对MCP-1、T细胞亚群的变化研究[J]. 中华中医药学刊,2023,41(6):169-172.
[4]	谷风,严英,陶红星. 利湿化瘀中药对慢性盆腔炎血液流变学及血清C-反应蛋白的影响[J]. 中华中医药杂志,2011,26(5):1102-1105.
[5]	沈凡琪,韩延华,刘丽. 中医药治疗盆腔炎性疾病相关信号通路的研究进展[J]. 中国实验方剂学杂志,2023,29(18):251-258.
[6]	《中成药治疗优势病种临床应用指南》标准化项目组. 中成药治疗盆腔炎性疾病后遗症临床应用指南(2020年)[J]. 中国中西医结合杂志,2021,41(3):286-299.
[7]	禹立芳. 金刚藤胶囊配伍康妇消炎栓治疗盆腔炎性包块100例临床观察[J]. 中国妇幼保健,2011,26(33):5249-5250.
[8]	中华医学会妇产科学分会感染性疾病协作组. 盆腔炎症性疾病诊治规范(2019修订版)[J]. 中华妇产科杂志,2019,54(7):433-437.
[9]	陈花兰. 金刚藤胶囊联合左氧氟沙星治疗盆腔炎性疾病的临床疗效研究[J]. 临床合理用药杂志,2021,14(36):42-44.
[10]	陈静. 金刚藤胶囊联合替硝唑注射液及注射用头孢硫脒治疗慢性盆腔炎的临床效果[J]. 河南医学研究,2020,29(11):2046-2047.
[11]	陈晓琴,李云秀. 金刚藤胶囊配合乳酸司帕沙星片对慢性盆腔炎的临床疗效[J]. 检验医学与临床,2018,15(3):356-358.
[12]	管晓燕. 金刚藤胶囊联合注射用头孢硫脒及替硝唑注射液治疗54例慢性盆腔炎的临床研究[J]. 北方药学,2019,16(5):100-101.
[13]	郝霞,李蔚. 金刚藤胶囊结合头孢曲松钠和甲硝唑对慢性盆腔炎血清CRP、IL-6、IL-10和MMP-2水平的影响[J]. 中华中医药学刊,2021,39(11):182-185.
[14]	郝玉珠,张洁洁. 金刚藤胶囊联合左氧氟沙星治疗慢性盆腔炎患者的效果[J]. 实用中西医结合临床,2023,23(4):29-32.
[15]	胡开泰. 金刚藤胶囊联合甲硝唑对慢性盆腔炎患者炎症因子的影响[J]. 医药界,2019,4(8):49-49.
[16]	乐丽莎. 金刚藤胶囊联合克林霉素磷酸酯治疗慢性盆腔炎的疗效及对血清炎症因子水平和血液流变学的影响[J]. 广西医科大学学报,2019,36(1):71-74.
[17]	雷敏. 金刚藤胶囊治疗慢性盆腔炎的临床疗效观察[J]. 中文科技期刊数据库(全文版)医药卫生,2022,1(6):21-24.
[18]	冷晓华. 司帕沙星与金刚藤胶囊对慢性盆腔炎患者的疗效分析[J]. 中国保健营养,2020,30(26):263-264.
[19]	李春红,揭慧颖,揭长芳. 金刚藤胶囊联合左氧氟沙星及甲硝唑对慢性盆腔炎患者血清炎症介质的影响[J]. 医疗装备,2021,34(13):107-108.
[20]	李海霞. 金刚藤软胶囊联合常规抗菌药物治疗慢性盆腔炎35例[J]. 中国药业,2015,24(12):88-89.
[21]	莫培晖,兰代群,闫志强. 慢性盆腔炎患者辅助使用金刚藤治疗过程中体内微环境的变化及临床意义分析[J]. 中国性科学,2018,27(9):82-84.
[22]	欧阳静. 金刚藤胶囊联合西药对慢性盆腔炎患者症状改善及血清CD4⁺/CD8⁺水平的影响[J]. 慢性病学杂志,2018,19(12):1753-1754.
[23]	潘春芳,李小燕. 金刚藤胶囊联合阿奇霉素对慢性盆腔炎的治疗有效率及临床证候改善情况分析[J]. 中外女性健康研究,2021,11(22):62-63. doi: 10.3969/j.issn.2096-0417.2021.22.zwnxjkyj202122029
[24]	孙小梅. 金刚藤胶囊联合头孢菌素类抗菌药物及替硝唑治疗慢性盆腔炎患者的临床疗效[J]. 医学理论与实践,2021,34(3):466-467.
[25]	王静. 金刚藤胶囊联合克林霉素磷酸酯治疗慢性盆腔炎患者的效果[J]. 中国民康医学,2021,33(7):77-79. doi: 10.3969/j.issn.1672-0369.2021.07.032
[26]	王文平,黄锦,敬巧,等. 金刚藤胶囊联合甲硝唑治疗对慢性盆腔炎患者效果、生活质量及炎性因子水平的影响[J]. 中外医学研究,2021,19(11):12-15.
[27]	王文霞,白文佩. 金刚藤胶囊联合阿奇霉素治疗慢性盆腔炎的临床研究[J]. 现代药物与临床,2018,33(5):1164-1167.
[28]	杨建美. 金刚藤胶囊联合头孢曲松钠、阿奇霉素治疗盆腔炎性疾病的临床效果分析[J]. 临床医药文献电子杂志,2020,7(87):140-140.
[29]	尹燕,高彩云,席丽. 盐酸左氧氟沙星与金刚藤联合治疗盆腔炎的效果观察[J]. 齐齐哈尔医学院学报,2016,37(32):4053-4054.
[30]	余月萍,白君. 金刚藤胶囊治疗慢性盆腔炎临床研究[J]. 新中医,2020,52(12):101-103.
[31]	袁翀英,王雅丽. 金刚藤胶囊联合头孢美唑钠治疗慢性盆腔炎的临床研究[J]. 现代药物与临床,2020,35(8):1605-1608.
[32]	朱文婷,梅玉英,李海琴. 金刚藤胶囊联合司帕沙星对慢性盆腔炎患者血清炎症因子水平及免疫功能的影响[J]. 临床医药实践,2020,29(11):817-820.
[33]	王华斌. 桂枝茯苓丸辅治慢性盆腔炎疗效及对血液流变学、氧化应激和血清hs-CRP、TGF-β1、GM-CSF、补体C3水平的影响[J]. 中华中医药学刊,2020,38(2):214-217.
[34]	贾利平,刘玉珠,周小飞. 中西医结合治疗慢性盆腔炎疗效观察及安全性分析[J]. 中华中医药学刊,2018,36(4):939-941.
[35]	林华,刘永逸. 金刚藤化学成分及其质量控制分析方法研究概述[J]. 中国药物评价,2022,39(6):456-460.
[36]	李筠,陈刚. 金刚藤胶囊对慢性盆腔炎大鼠盆腔粘连的作用及其药理机制[J]. 中药药理与临床,2020,36(1):144-149.
[37]	梅明,谢岱,林世和,等. 金刚藤多糖的水提工艺及影响大鼠慢性盆腔炎血液流变研究[J]. 中国药师,2021,24(8):436-439.
[38]	覃红珍,黄臻,刘晓琰,等. 金刚藤多糖对慢性盆腔炎大鼠的作用及机制[J]. 中国临床药理学杂志,2020,36(24):4039-4041,4053.
[39]	邓高丕. 金刚藤胶囊治疗湿热瘀结型盆腔炎、附件炎的临床疗效观察[J]. 中药材,2007,(5):623-625.
[40]	郭艳. 金刚藤胶囊治疗慢性盆腔炎疗效观察[J]. 中外妇儿健康,2011,19(7):37-39.
[41]	任妮,翟凤霞,郭淼,等. 中成药辅助治疗湿热瘀结型盆腔炎性疾病后遗症有效性及安全性的网状Meta分析[J]. 现代中西医结合杂志,2022,31(4):532-539.

Relative Articles(20)

Relative Articles

[1]	Caini ZHANG, Ya LI. A Meta-analysis of the Efficacy and Safety of Camrelizumab Combined with Chemotherapy in the Treatment of Non-small Cell Lung Cancer. Journal of Kunming Medical University, 2024, 45(6): 75-84. doi: 10.12259/j.issn.2095-610X.S20240610
[2]	Shuang FANG, Libo ZHU, Ling LIU, Yanhua XU, Xue HU. Meta-analysis of the Impact of Early Enteral Nutrition on the Clinical Outcomes of Very Low Birth Weight Premature Infants. Journal of Kunming Medical University, 2024, 45(9): 129-135. doi: 10.12259/j.issn.2095-610X.S20240920
[3]	Ya LUO, Yanting YU, Xue ZHANG, Zhongjuan WANG. A Meta-analysis of the Risk of Secondary Infection of Tocilizumab in the Treatment of COVID-19. Journal of Kunming Medical University, 2024, 45(2): 57-64. doi: 10.12259/j.issn.2095-610X.S20240208
[4]	Leijing RAN, Shaohua WANG, Lintong LI, Li GUI. A Meta-analysis of the Effect of Adjuvant Probiotics in Patients with Osteoporosis. Journal of Kunming Medical University, 2024, 45(2): 65-76. doi: 10.12259/j.issn.2095-610X.S20240209
[5]	Shiyao YANG, Yanxia YANG, Haiyin YANG, Yong DONG, Jinhu MIAO, Yuexi ZHU, Qiongyao GUAN. A Systematic Evaluation of Incidence and Influencing Factors of Falls in Adult Cancer Patients. Journal of Kunming Medical University, 2024, 45(12): 1-10.
[6]	Qingmei YU, Tao SHI, Hongxue GUAN, Yujun MAO, Zhaoyi LI, Jiao YANG. Prevalence and Influence Factors of Renal Function Impairment in Patients Following Radical Cystectomy：A Systematic Review and Meta-analysis. Journal of Kunming Medical University, 2024, 45(9): 83-90. doi: 10.12259/j.issn.2095-610X.S20240913
[7]	Huaping WANG, Dingyun YOU, Yanhong YANG, Bowen CHEN, Yue HUAN, Rui LIAO. A Meta Analysis of the Incidence of Stillbirth in Pregnant and Postpartum Women in China from 1994 to 2020. Journal of Kunming Medical University, 2023, 44(9): 15-24. doi: 10.12259/j.issn.2095-610X.S20230907
[8]	Xiaodie YAO, Hao FAN, Lingjun SHEN, Shengan ZHENG, Menghan JIANG, Lei SHEN, Jie CHEN, Xing LIU. Network Meta-Analysis of Three Different Interventional Methods for the Treatment of Tracheobronchial Tuberculosis. Journal of Kunming Medical University, 2023, 44(9): 110-120. doi: 10.12259/j.issn.2095-610X.S20230912
[9]	Sun Xing Yun , Liu Xia , Meng Fan Xing , Wang Le , Wang Feng Li . . Journal of Kunming Medical University, 2020, 41(08): 18-26.
[10]	Jie Chun Lin , Huang Tao , Teng Zhao Wei , Bu Jun Hui , Li Meng Zhou , Zhang Jing. . Journal of Kunming Medical University, 2019, 40(04): 91-96.
[11]	Lin Yun Ke , Lin Yun Hong . . Journal of Kunming Medical University, 2019, 40(10): 50-56.
[12]	Feng Lin Sen , Li Jing Juan , Wang Yu Feng . A Meta-analysis of rh-endostatin Combined with Chemotherapy in the Treatment of Advanced Breast Cancer. Journal of Kunming Medical University, 2017, 38(06): 118-123.
[13]	Weng Xiao Chun , Li Chun , Zhou Song Lan , Tang Zhe , Peng Bao Kun . Meta Analysis of Effectiveness of Vacuum Sealing Drainage in the Treatment of Diabetic Foot Ulcer. Journal of Kunming Medical University, 2017, 38(04): 80-83.
[14]	Zhang Wei . Meta Analysis of ADAM33 T1，S2 Polymorphism and the Susceptibility of Bronchial Asthma in China. Journal of Kunming Medical University,
[15]	Ke Zi Li . . Journal of Kunming Medical University,
[16]	Zeng Hai Ping . . Journal of Kunming Medical University,
[17]	Deng Peng Peng . . Journal of Kunming Medical University,
[18]	Zhou Jie . . Journal of Kunming Medical University,
[19]	. . Journal of Kunming Medical University,
[20]	. Sanchinoside for Diabetic Peripheral Neuropathy:A Meta Analysis. Journal of Kunming Medical University,