Cost-Effectiveness Analysis of Nilotinib Versus Dasatinib as Second-Line Treatment of Chronic Myeloid Leukemia

Ling MA; Yanhong ZHAO; Jia LIU; Wenlian TU

doi:10.12259/j.issn.2095-610X.S20240413

Volume 45 Issue 4

Apr. 2024

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Teng Yan . Effect of Hemoperfusion on Inflammation Factors in Patients with Sepsis[J]. Journal of Kunming Medical University, 2016, 37(05).

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Ling MA, Yanhong ZHAO, Jia LIU, Wenlian TU. Cost-Effectiveness Analysis of Nilotinib Versus Dasatinib as Second-Line Treatment of Chronic Myeloid Leukemia[J]. Journal of Kunming Medical University, 2024, 45(4): 92-98. doi: 10.12259/j.issn.2095-610X.S20240413

Teng Yan . Effect of Hemoperfusion on Inflammation Factors in Patients with Sepsis[J]. Journal of Kunming Medical University, 2016, 37(05).

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Cost-Effectiveness Analysis of Nilotinib Versus Dasatinib as Second-Line Treatment of Chronic Myeloid Leukemia

doi: 10.12259/j.issn.2095-610X.S20240413

1.
Dept. of Clinnical Pharmacy，The 1st People’s Hospital of Yunnan Province/ The Affiliated Hospital of Kunming University of Science and Technology/ Clinical pharmacy Center of Yunnan Province ，Kunming Yunnan 650032
2.
School of Pharmaceutical Sciences，Kunming Medical University，Kunming Yunnan 650500，China

Received Date: 2023-12-20
Available Online: 2024-04-06
Publish Date: 2024-04-29

Abstract

Abstract

Objective To evaluate the cost-effectiveness of nilotinib versus dasatinib in the second-line treatment of Philadelphia chromosome-positive chronic myeloid leukemia in chronic phase. Methods Establish a Markov model for cost-effectiveness analysis, including four health states: chronic phase （CP）, accelerated phase （AP）, blast phase （BP）, and death. Clinical parameters related to progression-free survival rates, disease progression rates, overall survival rates, etc. for treatment with nilotinib and dasatinib are derived from previously published studies and expert opinions, while health state utility values are sourced from the literature. Using Treeage software, the incremental cost-effectiveness ratio （ICER） was used as an evaluation metric to assess the total output and total costs of the two schemes of nilotinib and dasatinib, and model stability is evaluated through univariate and probabilistic sensitivity analyses. Results Compared with using dasatinib for treatment, the ICER for using nilotinib treatment is 182487.71 yuan per QALY, which is less than 3 times the national per capita GDP in 2021. Sensitivity analysis showed that the main influencing parameters are the discount rate, dasatinib price, and nilotinib price, and the model results are stable. Conclusion Nilotinib has a cost-utility advantage over dasatinib in the treatment of Ph+CML-CP patients who are resistant or intolerent to imatinib.
- Nilotinib,
- Dasatinib,
- Chronic myeloid leukemia,
- Cost-effectiveness analysis,
- Second-line treatment

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References

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