Changes of Immunoglobulin in TACE Treatment of Hepatocellular Carcinoma and Its Value in Predicting Curative Effect

Lanzhu YAN; Shunyi QIAO; Yanli ZHANG; Erqiang ZHAO; Hu YANG; Jing LIN; Haiyan FU

doi:10.12259/j.issn.2095-610X.S20240418

Volume 45 Issue 4

Apr. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(4): 128-134

Lanzhu YAN, Shunyi QIAO, Yanli ZHANG, Erqiang ZHAO, Hu YANG, Jing LIN, Haiyan FU. Changes of Immunoglobulin in TACE Treatment of Hepatocellular Carcinoma and Its Value in Predicting Curative Effect[J]. Journal of Kunming Medical University, 2024, 45(4): 128-134. doi: 10.12259/j.issn.2095-610X.S20240418

Citation:

Lanzhu YAN, Shunyi QIAO, Yanli ZHANG, Erqiang ZHAO, Hu YANG, Jing LIN, Haiyan FU. Changes of Immunoglobulin in TACE Treatment of Hepatocellular Carcinoma and Its Value in Predicting Curative Effect[J]. Journal of Kunming Medical University, 2024, 45(4): 128-134. doi: 10.12259/j.issn.2095-610X.S20240418

Citation:

Lanzhu YAN, Shunyi QIAO, Yanli ZHANG, Erqiang ZHAO, Hu YANG, Jing LIN, Haiyan FU. Changes of Immunoglobulin in TACE Treatment of Hepatocellular Carcinoma and Its Value in Predicting Curative Effect[J]. Journal of Kunming Medical University, 2024, 45(4): 128-134. doi: 10.12259/j.issn.2095-610X.S20240418

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Changes of Immunoglobulin in TACE Treatment of Hepatocellular Carcinoma and Its Value in Predicting Curative Effect

doi: 10.12259/j.issn.2095-610X.S20240418

Lanzhu YAN¹,
Shunyi QIAO¹,
Yanli ZHANG¹,
Erqiang ZHAO¹,
Hu YANG¹,
Jing LIN^{2
,
,},
Haiyan FU^{1, 2, 3}

1.
Dept. of Laboratory and Pathology
2.
Dept. of Internal Medicine，Hebei Armed Police Corps Hospital，Shijiazhuang Hebei 050080
3.
Dept. of Oncology，The 1st Hospital of Hebei Medical University，Shijiazhuang Hebei 050030，China

Received Date: 2023-11-29
Available Online: 2024-04-03
Publish Date: 2024-04-29

Abstract

Abstract

Objective To analyze the changes of immunoglobulin （Ig） during the process of transcatheter arterial chemoembolization （TACE） for hepatocellular carcinoma （HCC） and predict the value of treatment efficacy. Methods A total of 100 HCC patients in Hebei Armed Police Corps Hospital from January 2022 to January 2023 were selected as the liver cancer group, 50 patients with benign liver disease were selected as the benign group, and 50 healthy volunteers were selected as the control group. The general data, serum Ig （IgA, IgG, IgM） and conventional tumor markers [alpha-fetoprotein （AFP）, cytokeratin 19 （CK19）, Golgi protein 73 （GP73）], and the correlation between serum Ig and conventional tumor markers in the HCC group was analyzed. The serum levels and changes of Ig and conventional tumor markers in patients with different efficacy after TACE treatment in the liver cancer group were compared before and after treatment. The correlation between the changes of serum Ig and conventional tumor markers and the efficacy of ACE was analyzed, and the predictive value of ACE prediction scheme with or without Ig was compared. Results The levels of IgA, IgG and IgM in liver cancer group were lower than those in benign group and control group; the levels of AFP, CK19 and GP73 in liver cancer group were higher than those in benign group and control group; the levels of IgA, IgG and IgM in benign group were lower than those in control group; the levels of AFP, CK19 and GP73 in benign group were higher than those in control group （P < 0.05）. Serum IgA, IgG and IgM levels were negatively correlated with serum AFP, CK19 and GP73 levels in HCC group （P < 0.05）. The serum levels of IgA, IgG and IgM in patients with poor TACE treatment were lower than those in patients with good efficacy before and after treatment, the levels of AFP, CK19 and GP73 were higher than those in patients with good efficacy, and △IgA, △IgG, △IgM, △AFP, △CK19 and △GP73 were lower than those in patients with good efficacy （P < 0.05）. △IgA, △IgG, △IgM, △AFP, △CK19, △GP73 were positively correlated with the therapeutic effect of TACE （P < 0.05）. The area under the curve （AUC） of △IgA, △IgG, △IgM, △AFP, △CK19 and △GP73 for predicting poor TACE efficacy in HCC patients were 0.777, 0.784, 0.793, 0.779, 0.710 and 0.746, respectively. Compared with the non-IG prediction scheme （△AFP, △CK19, △GP73 combined prediction）, the AUC with Ig prediction scheme （△IgA, △IgG, △IgM, △AFP, △CK19, △GP73 combined prediction） was significantly increased in predicting poor TACE efficacy in HCC patients. Both NRI and IDI were > 0 （P < 0.05）. Conclusion The levels of serum IgA, IgG and IgM in HCC patients increased during TACE treatment, and the changes of each index can provide a reliable basis for clinical prediction of TACE efficacy.
- Hepatocellular carcinoma,
- Immunoglobulin,
- Hepatic artery chemoembolization for liver cancer,
- Curative effect,
- Forecast

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