Correlation between Gut Microbiota，Serum ET，PCT Levels with the Severity and Prognosis of Sepsis

Junjie NIU; Wenjuan JI; Zhuaizhuai YU

doi:10.12259/j.issn.2095-610X.S20240420

Volume 45 Issue 4

Apr. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(4): 140-145

Junjie NIU, Wenjuan JI, Zhuaizhuai YU. Correlation between Gut Microbiota，Serum ET，PCT Levels with the Severity and Prognosis of Sepsis[J]. Journal of Kunming Medical University, 2024, 45(4): 140-145. doi: 10.12259/j.issn.2095-610X.S20240420

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Junjie NIU, Wenjuan JI, Zhuaizhuai YU. Correlation between Gut Microbiota，Serum ET，PCT Levels with the Severity and Prognosis of Sepsis[J]. Journal of Kunming Medical University, 2024, 45(4): 140-145. doi: 10.12259/j.issn.2095-610X.S20240420

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Correlation between Gut Microbiota，Serum ET，PCT Levels with the Severity and Prognosis of Sepsis

doi: 10.12259/j.issn.2095-610X.S20240420

Dept. of Clinical Laboratory，Jincheng General Hospital，Jincheng Shanxi 048006，China

Received Date: 2023-09-25
Available Online: 2024-04-03
Publish Date: 2024-04-29

Abstract

Abstract

Objective To investigate the correlation between the levels of intestinal flora, serum endotoxin （ET）, and procalcitonin （PCT） in patients with sepsis and their disease severity and prognosis. Methods A total of 373 patients with sepsis in Jincheng University Hospital from January 2016 to December 2022 were selected and divided into sepsis group （n=261） and sepsis shock group （n=112） according to the severity of sepsis. The general data, intestinal flora, serum ET and PCT levels were compared between the two groups, and the serum ET and PCT levels were compared among patients with different degrees of intestinal flora disturbance. The relationship between serum PCT and ET levels and the degree of intestinal flora disturbance in sepsis was analyzed.The prognosis of patients for 28 days was statistically analyzed, and the intestinal flora, serum ET, and PCT levels at the time of admission were compared between dead and alive patients to analyze the value of intestinal flora, serum ET, and PCT levels in predicting prognosis. Results Patients in the septic shock group had lower counts of bifidobacteria and lactobacilli compared to the sepsis group, while counts of Escherichia coli, enterococci, as well as serum levels of ET and PCT were higher in the septic shock group. The severity of disruption in gut microbiota was associated with higher serum levels of ET and PCT, with level III patients having higher levels than level II and level I patients. The levels of ET and PCT in septic patients were positively correlated with the severity of disruption in gut microbiota. Upon admission, deceased patients had lower counts of bifidobacteria and lactobacilli compared to surviving patients, while counts of enterococci, Escherichia coli, as well as serum levels of ET and PCT were higher in deceased patients. The predictive value for prognosis of death for bifidobacteria, enterococci, Escherichia coli, lactobacilli, ET, and PCT were 0.788, 0.782, 0.787, 0.768, 0.791, and 0.776 respectively. The combined predictive value had the highest AUC of 0.928. Conclusion The intestinal flora, serum ET, and PCT levels in patients with sepsis are closely related to the severity of the disease and have good application value in predicting prognosis.
- Sepsis,
- Intestinal microbiota,
- Endotoxins,
- Procalcitonin,
- Prognosis

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References(21)

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