A Clinical Study of Vonoprazan Fumarate Tablets for the Treatment of Non-erosive Reflux Disease

Xiaoyun LI; Jiahao LIU; Weiwei ZHANG; Rongjian CAO; Yan LIU; Zhenguang QI

doi:10.12259/j.issn.2095-610X.S20240421

Volume 45 Issue 4

Apr. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(4): 146-151

Xiaoyun LI, Jiahao LIU, Weiwei ZHANG, Rongjian CAO, Yan LIU, Zhenguang QI. A Clinical Study of Vonoprazan Fumarate Tablets for the Treatment of Non-erosive Reflux Disease[J]. Journal of Kunming Medical University, 2024, 45(4): 146-151. doi: 10.12259/j.issn.2095-610X.S20240421

Citation:

Xiaoyun LI, Jiahao LIU, Weiwei ZHANG, Rongjian CAO, Yan LIU, Zhenguang QI. A Clinical Study of Vonoprazan Fumarate Tablets for the Treatment of Non-erosive Reflux Disease[J]. Journal of Kunming Medical University, 2024, 45(4): 146-151. doi: 10.12259/j.issn.2095-610X.S20240421

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A Clinical Study of Vonoprazan Fumarate Tablets for the Treatment of Non-erosive Reflux Disease

doi: 10.12259/j.issn.2095-610X.S20240421

1.
Dept. of Education，The 8th People’s Hospital of Qingdao，Qingdao Shandong 266041
2.
Minimally Invasive Interventional Treatment Center
3.
Dept. of Gastroenterology，East Branch，Qingdao Municipal Hospital ，Qingdao Shandong 266071
4.
Dept. of Infectious Diseases，Yinan County People's Hospital，Yinan Shandong 276000
5.
Dept. of Gastroenterology，The Affiliated Hospital of Qingdao University，Qingdao Shandong 266003
6.
Dept. of Gastroenterology，The 8th People’s Hospital of Qingdao，Qingdao Shandong 266041，China

Received Date: 2022-11-23
Available Online: 2023-12-22
Publish Date: 2024-04-29

Abstract

Abstract

Objective To study the efficacy and adverse reactions of vonoprazan fumarate tablets and esomeprazole magnesium enteric-coated tablets in the treatment of non-erosive reflux disease（NERD）. Methods A total of 124 patients with NERD were selected and divided into treatment group（62 cases） and control group（62 cases） by random number table method. Treatment group received vohoprazan fumarate tablet, while control group received esomeprazole magnesium enteric-coated tablet, and the course of treatment was 4 weeks. HP was eradicated in helicobacter pylori（HP）-positive patients. The clinical efficacy, reflux disease questionnaire（RDQ ）score, pittsburgh sleep quality index score, changes of esophageal pH before and after treatment、HP eradication rate and incidence of adverse reactions were compared between the two groups. Results The treatment group showed a higher overall effectiveness compared to the control group（P < 0.05）. After treatment, the RDQ scores in the treatment group were lower than those in the control group（P < 0.05）. Similarly, the PSQI scores in the treatment group were lower than those in the control group（P < 0.05）. Additionally, the treatment group exhibited fewer reflux episodes with pH < 4, reflux episodes lasting > 5 minutes, and a lower total time with pH < 4 compared to the control group（P < 0.05）. The eradication rate of HP in the treatment group was higher than that in the control group（P < 0.05）. There was no significant difference in the overall rate of adverse reactions between the treatment group and the control group（P > 0.05）. Conclusion In the treatment of non-erosive reflux disease, compared to esomeprazole magnesium enteric-coated tablets, vonoprazan fumarate tablets show significant efficacy, improve sleep quality, provide stronger acid suppression, increase the eradication rate of Helicobacter pylori（HP）, and do not increase adverse reactions.
- Vonoprazan fumarate tablets,
- Esomeprazole magnesium enteric-coated tablets,
- Non-erosive reflux disease

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