Volume 45 Issue 4
Apr.  2024
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Article Navigation >  Journal of Kunming Medical University  > 2024  >  45(4): 157-162
Wenxiu XU, Xiaofeng MO, Xiangmin YANG, Silu YANG, Fan WU, Te LI. Application of Logistic Regression and Decision Tree Model in Prediction of Adverse Reactions of Iodinated Contrast Medium[J]. Journal of Kunming Medical University, 2024, 45(9): 70-75. doi: 10.12259/j.issn.2095-610X.S20240911
Citation: Jihong LIU, Zhiqiang MA, Lin WANG, Xiaoyan WANG, Weiguang TIAN, Baoping LI, Rui DONG, Yujia LV. Correlation Analysis of Immune Function of Tuberculosis Patients Infected with COVID-19[J]. Journal of Kunming Medical University, 2024, 45(4): 157-162. doi: 10.12259/j.issn.2095-610X.S20240423
shu

Correlation Analysis of Immune Function of Tuberculosis Patients Infected with COVID-19

doi: 10.12259/j.issn.2095-610X.S20240423

  • The 3rd People’s Hospital of Kunming/ Yunnan Clinical Medical Center for Infectious Disease，Kunming Yunnan 650301，China

  • Received Date: 2023-12-28
    Available Online: 2024-04-03
  • Publish Date: 2024-04-29
    Abstract
  •   Objective  To analyze the immunological indicators of TB patients co-infected with COVID-19, clarify their immune status, and explore the relationship and characteristics of relevant indicators with immune status.   Methods  The study group consisted of TB patients infected with COVID-19 admitted to the Third People's Hospital of Kunming City （n = 111）, while TB patients who were not infected with COVID-19 during the same period were selected as the control group （n = 1649） for the analysis of serum immunological indicators.  Results  After excluding confounding factors such as age and gender through PSM propensity matching, the TB-COVID group showed lower levels of CD19+, CD3+, CD4+, lymphocyte, and IL-8 compared to the TB group, while IL-10, IL-17, and IL-6 were higher in the TB-COVID group, with statistically significant differences （P < 0.05）. ROC curve analysis of the above differing indicators was performed to analyze the immune risk factors of TB-COVID. The sensitivity and specificity of CD19+, IL-10, and IL-6 for TB infection with COVID-19 were 71.4% and 56.7%, 59.1% and 77.0%, 59.1% and 77.7%, respectively. The AUC values were 0.659 （95%CI: 0.583～0.736, P < 0.05）, 0.645 （95%CI: 0.558～0.732, P < 0.05）, and 0.649 （95%CI: 0.564～0.734, P < 0.05）. When comparing subgroups based on age, in the TB-COVID group, IL-1β, IL-2, IL-4, IL-8, TFN-α, and IL-12p70 sharply increased in the 21-40 age group far beyond the TB group, and gradually declined with increasing age.   Conclusion  TB patients have a weakened immune system after being infected with COVID-19, with multiple immune indicators lower compared to TB patients. This is related to cell immunity and cytokine storm, so we need to pay more attention to TB-COVID cases.
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