Clinical Implications of Serum LDH，CysC，and PWR Level Detection in Lung Cancer Patients

Ying WANG; Cong FU; Ying FU

doi:10.12259/j.issn.2095-610X.S20240424

Volume 45 Issue 4

Apr. 2024

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Ying WANG, Cong FU, Ying FU. Clinical Implications of Serum LDH，CysC，and PWR Level Detection in Lung Cancer Patients[J]. Journal of Kunming Medical University, 2024, 45(4): 163-169. doi: 10.12259/j.issn.2095-610X.S20240424

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Ying WANG, Cong FU, Ying FU. Clinical Implications of Serum LDH，CysC，and PWR Level Detection in Lung Cancer Patients[J]. Journal of Kunming Medical University, 2024, 45(4): 163-169. doi: 10.12259/j.issn.2095-610X.S20240424

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Clinical Implications of Serum LDH，CysC，and PWR Level Detection in Lung Cancer Patients

doi: 10.12259/j.issn.2095-610X.S20240424

Dept. of Medical Record Statistics，The 4th People’s Hospital of Changzhou City，Changzhou Jiangsu 213000，China

Received Date: 2023-12-28
Available Online: 2024-04-07
Publish Date: 2024-04-29

Abstract

Abstract

Objective To investigate the clinical implications of lung function index, serum lactate dehydrogenase（LDH）, cysteine protease inhibitor C（CysC） and platelet/white blood cell ratio（PWR） in patients with lung cancer. Methods From January 2023 to June 2023, 72 patients with lung cancer in the Fourth People's Hospital of Changzhou were selected as the observation group, and 72 patients with benign lung diseases during the same period were selected as the control group. LDH, CysC, PWR and tumor markers [carcinoembryonic antigen（CEA）, neuron-specific enolase（NSE）, cytokeratin fragment 19（CYFRA21-1）] were compared between the two groups, and the correlation between LDH, PWR, CysC and tumor markers was analyzed. The levels of LDH, CysC and PWR in patients with lung cancer with different pathological characteristics were compared, and the correlation between the levels of LDH, PWR, CysC and pathological characteristics in patients with lung cancer was analyzed. The diagnostic value of LDH, CysC, PWR combined with CEA, CYFRA21-1 and NSE in lung cancer was evaluated. Results The PWR of the observation group was lower than that of the control group, and the LDH, CysC, CEA, CYFRA21-1 and NSE were higher than those of the control group（P < 0.05）. PWR was negatively correlated with tumor markers CEA, CYFRA21-1 and NSE（P < 0.05）, LDH and CysC were positively correlated with tumor markers CEA, CYFRA21-1 and NSE（P < 0.05）. There was no significant difference in LDH, CysC and PWR between lung adenocarcinoma and lung squamous cell carcinoma（P > 0.05）. In terms of clinical stage, PWR of stage Ⅰ- Ⅱ patients was higher than that of stage Ⅲ-Ⅳ patients, LDH and CysC were lower than those of stage Ⅲ-Ⅳ patients（P < 0.05）. In terms of lymph node metastasis, the PWR of patients without lymph node metastasis was higher than that of patients with lymph node metastasis, and LDH and CysC were lower than those of patients with lymph node metastasis（P < 0.05）. LDH, PWR and CysC in lung cancer patients were not correlated with pathological type（P > 0.05）, PWR was negatively correlated with clinical stage and lymph node metastasis（P < 0.05）, LDH and CysC were positively correlated with clinical stage and lymph node metastasis（P < 0.05）. The ROC curve showed that the area under the curve（AUC） value of the combination of LDH, CysC and PWR in the diagnosis of lung cancer was 0.910, and the AUC value of the combination of CEA, CYFRA21-1 and NSE was 0.923. Further use of LDH, CysC, PWR combined with CEA, CYFRA21-1, NSE diagnostic AUC value was the highest, 0.940, the sensitivity and specificity were 93.06% and 87.33%, respectively. Conclusion The PWR of lung cancer patients is decreased, and the levels of LDH and CysC are increased, and their levels are closely related to tumor markers, clinical stage and lymph node metastasis, which can assist tumor markers in the diagnosis of lung cancer, in order to improve the diagnosis rate of early lung cancer.
- Lung cancer,
- Lactate dehydrogenase,
- Cysteine protease inhibitor C,
- Platelet/leukocyte ratio

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