Volume 45 Issue 5
May  2024
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Article Navigation >  Journal of Kunming Medical University  > 2024  >  45(5): 8-15
Zhixin NIU, Lihua TANG, Lei SHI, Chao HONG, Yufeng YAO, Zhiling YAN. Correlation of MAPK1 and NRAS Gene Polymorphisms with Cervical Intraepithelial Neoplasia in Yunnan Han Population[J]. Journal of Kunming Medical University, 2024, 45(5): 8-15. doi: 10.12259/j.issn.2095-610X.S20240502
Citation: Zhixin NIU, Lihua TANG, Lei SHI, Chao HONG, Yufeng YAO, Zhiling YAN. Correlation of MAPK1 and NRAS Gene Polymorphisms with Cervical Intraepithelial Neoplasia in Yunnan Han Population[J]. Journal of Kunming Medical University, 2024, 45(5): 8-15. doi: 10.12259/j.issn.2095-610X.S20240502
shu

Correlation of MAPK1 and NRAS Gene Polymorphisms with Cervical Intraepithelial Neoplasia in Yunnan Han Population

doi: 10.12259/j.issn.2095-610X.S20240502
  • 1.

    Institute of Medical Biology，Chinese Academy of Medical Sciences & Peking Union Medical College，Kunming Yunnan 650118

  • 2.

    Dept. of Gynecology，The 1st People’s Hospital of Yuanmou County，Yuanmou Yunnan 651300

  • 3.

    Dept. of Gynecology，The 3rd Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650118，China

  • Received Date: 2024-01-16
    Available Online: 2024-04-29
  • Publish Date: 2024-05-31
    Abstract
  •   Objective  NRAS and MAPK1 genes are important regulators of the Ras/Raf/MEK/ERK signaling pathway, and their functions and expression levels have been associated with a variety of human tumors. This study aims to investigate the correlation between the rs14804 and rs9340 polymorphic loci of NRAS and MAPK1 genes and the susceptibility to cervical intraepithelial neoplasia （CIN） in Yunnan Han population.   Methods  1399 persons of the population were enrolled in the current study, with 416 as the CIN patient group and 983 as the healthy control group. The SNPs loci （rs14804 and rs9340） in the NRAS gene and the MAPK1 gene were genotyped using the TaqMan assays, and the correlation between the two SNPs loci and the risk of CIN was analyzed.   Results  The difference in the frequency of distribution of SNP locus rs9340 allele （P = 0.008） and genotype （P = 0.002） of MAPK1 gene in the CIN group versus the control group was statistically significant, and allele A may be associated with a higher risk of developing CIN （OR = 1.28, 95%CI 1.07 ～ 1.54）, especially for people in the lower age group （≤ 50 years） of CIN risk （OR = 1.35, 95%CI 1.09 ～ 1.67）.   Conclusion  rs9340 in the MAPK1 gene might be correlated with the risk of CIN in the Chinese Han population in Yunnan.
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