Volume 45 Issue 5
May  2024
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You LI, Heng DING, Liang CUI, Yuanxi ZHAO, Enyu ZHAN, Xingguo LI. The Analysis of the Therapeutic Effect of Intervertebral Foramen Endoscopy on Single Segment Non-specific Lumbar Intervertebral Space Infection[J]. Journal of Kunming Medical University, 2024, 45(5): 94-102. doi: 10.12259/j.issn.2095-610X.S20240515
Citation: You LI, Heng DING, Liang CUI, Yuanxi ZHAO, Enyu ZHAN, Xingguo LI. The Analysis of the Therapeutic Effect of Intervertebral Foramen Endoscopy on Single Segment Non-specific Lumbar Intervertebral Space Infection[J]. Journal of Kunming Medical University, 2024, 45(5): 94-102. doi: 10.12259/j.issn.2095-610X.S20240515

The Analysis of the Therapeutic Effect of Intervertebral Foramen Endoscopy on Single Segment Non-specific Lumbar Intervertebral Space Infection

doi: 10.12259/j.issn.2095-610X.S20240515
  • Received Date: 2024-01-11
    Available Online: 2024-04-29
  • Publish Date: 2024-05-31
  •   Objective  To evaluate the efficiency of posterolateral approach in the treatment of single-segment nonspecific lumbar spondylodiscitis by observation of the clinical results of posterior lateral percutaneous transforaminal endoscopic debridement (PTED) approach and posterior single segmental lumbar debridement, bone graft and internal fixation in the treatment of single segment nonspecific lumbar spondylodiscitis.   Methods  In this study, 42 patients ( males 24 and females 18 with an average age of 54 years) with nonspecific lumbar spondylodiscitis treated in the Department of Orthopaedics of the 1st Affiliated Hospital of Kunming Medical University from June 2016 to June 2023 were analyzed retrospectively. They were divided into group A (n = 21) and group B (n = 21). All the patients in group A were treated with posterolateral percutaneous transforaminal endoscopic debridement combined with soft tissue immersion to improve the detection rate of etiology. All the patients in group B were treated with posterior single-segment lumbar focus debridement, bone graft and internal fixation. The visual analogue scale score of low back pain (VAS), Japanese Orthopaedic Association Lumbar vertebra score (JOA) and lumbar vertebra ODI scale were compared before and after the operation to evaluate the remission of clinical symptoms, infection indexes such as white blood cells, hypersensitive C-reactive protein, ESR, the therapeutic effect of pathogenic drug-resistant bacteria, bacterial culture rate and postoperative complications.  Results  The positive rate of pathogen culture obtained through posterior lateral percutaneous foramen debridement combined with soft tissue soaking method was 90%. The score of ODI in group A was lower than that in group B on the 7th day after operation. Among the infection indexes, CRP and ESR in group A were much lower than those in group B at 3 and 7 days after the operation, and the difference was statistically significant (P < 0.05).   Conclusion  Percutaneous transforaminal endoscopic debridement (PTED)in the treatment of lumbar spondylodiscitis combined with soft tissue immersion has a high bacterial culture rate, which can effectively reduce the pain of patients, improve the quality of life, and significantly reduce the index of infection. it is safe and effective for high-risk patients with multiple underlying diseases, strong bacterial virulence, high fever, high inflammation index, high risk of infection with internal fixation and inability to tolerate general anesthesia surgery.
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  • [1]
    Kourbeti I S,Tsiodras S,Boumpas D T. Spinal infections: Evolving concepts[J]. Curr Opin Rheumatol,2008,20(4):471-479. doi: 10.1097/BOR.0b013e3282ff5e66
    [2]
    Skaf G S,Domloj N T,Fehlings M G,et al. Pyogenic spondylodiscitis: An overview[J]. J Infect Public Health,2010,3(1):5-16. doi: 10.1016/j.jiph.2010.01.001
    [3]
    Cheung W Y,Luk K D. Pyogenic spondylitis[J]. Int Orthop,2012,36(2):397-404. doi: 10.1007/s00264-011-1384-6
    [4]
    Akiyama T,Chikuda H,Yasunaga H,et al. Incidence and risk factors for mortality of vertebral osteomyelitis: A retrospective analysis using the Japanese diagnosis procedure combination database[J]. BMJ Open,2013,3(3):e002412. doi: 10.1136/bmjopen-2012-002412
    [5]
    Milosevic B,Cevik M,Urosevic A,et al. Risk factors associated with poor clinical outcome in pyogenic spinal infections: 5-years' intensive care experience[J]. J Infect Dev Ctries,2020,14(1):36-41. doi: 10.3855/jidc.12260
    [6]
    Duarte R M,Vaccaro A R. Spinal infection: State of the art and management algorithm[J]. Eur Spine J,2013,22(12):2787-2799. doi: 10.1007/s00586-013-2850-1
    [7]
    D'Agostino C,Scorzolini L,Massetti A P,et al. A seven-year prospective study on spondylodiscitis: Epidemiological and microbiological features[J]. Infection,2010,38(2):102-107. doi: 10.1007/s15010-009-9340-8
    [8]
    Aljawadi A,Jahangir N,Jeelani A,et al. Management of pyogenic spinal infection,review of literature[J]. J Orthop,2019,16(6):508-512. doi: 10.1016/j.jor.2019.08.014
    [9]
    Chelsom J,Solberg C O. Vertebral osteomyelitis at a Norwegian university hospital 1987-97: Clinical features,laboratory findings and outcome[J]. Scand J Infect Dis,1998,30(2):147-151. doi: 10.1080/003655498750003537
    [10]
    Gasbarrini A L,Bertoldi E,Mazzetti M,et al. Clinical features,diagnostic and therapeutic approaches to haematogenous vertebral osteomyelitis[J]. Eur Rev Med Pharmacol Sci,2005,9(1):53-66.
    [11]
    Zarghooni K,Röllinghoff M,Sobottke R,et al. Treatment of spondylodiscitis[J]. Int Orthop,2012,36(2):405-411. doi: 10.1007/s00264-011-1425-1
    [12]
    Berbari E F,Kanj S S,Kowalski T J,et al. 2015 infectious diseases society of america (IDSA) clinical practice guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults[J]. Clin Infect Dis,2015,61(6):e26-46. doi: 10.1093/cid/civ482
    [13]
    Chew F S,Kline M J. Diagnostic yield of CT-guided percutaneous aspiration procedures in suspected spontaneous infectious diskitis[J]. Radiology,2001,218(1):211-214. doi: 10.1148/radiology.218.1.r01ja06211
    [14]
    Sehn J K,Gilula L A. Percutaneous needle biopsy in diagnosis and identification of causative organisms in cases of suspected vertebral osteomyelitis[J]. Eur J Radiol,2012,81(5):940-946. doi: 10.1016/j.ejrad.2011.01.125
    [15]
    Fouquet B,Goupille P,Gobert F,et al. Infectious discitis diagnostic contribution of laboratory tests and percutaneous discovertebral biopsy[J]. Rev Rhum Engl Ed,1996,63(1):24-29.
    [16]
    Lu M L,Niu C C,Tsai T T,et al. Transforaminal lumbar interbody debridement and fusion for the treatment of infective spondylodiscitis in the lumbar spine[J]. Eur Spine J,2015,24(3):555-560. doi: 10.1007/s00586-014-3585-3
    [17]
    Rutges J P,Kempen D H,van Dijk M,et al. Outcome of conservative and surgical treatment of pyogenic spondylodiscitis: A systematic literature review[J]. Eur Spine J,2016,25(4):983-999. doi: 10.1007/s00586-015-4318-y
    [18]
    Price D D,Mcgrath P A,Rafii A,et al. The validation of visual analogue scales as ratio scale measures for chronic and experimental pain[J]. Pain,1983,17(1):45-56. doi: 10.1016/0304-3959(83)90126-4
    [19]
    Kawakami M,Takeshita K,Inoue G,et al. Japanese Orthopaedic Association (JOA) clinical practice guidelines on the management of lumbar spinal stenosis,2021 - Secondary publication[J]. J Orthop Sci,2023,28(1):46-91. doi: 10.1016/j.jos.2022.03.013
    [20]
    Fairbank J. Revised oswestry disability questionnaire[J]. Spine (Phila Pa 1976),2000,25(19): 2552.
    [21]
    Abreu P G P,Lourenço J A,Romero C,et al. Endoscopic treatment of spondylodiscitis: Systematic review[J]. Eur Spine J,2022,31(7):1765-1774. doi: 10.1007/s00586-022-07142-w
    [22]
    Mao Y,Li Y,Cui X. Percutaneous endoscopic debridement and drainage for spinal infection: Systemic review and Meta-analysis[J]. Pain Physician,2019,22(4):323-330.
    [23]
    Yee D K,Samartzis D,Wong Y W,et al. Infective spondylitis in Southern Chinese: A descriptive and comparative study of ninety-one cases[J]. Spine (Phila Pa 1976),2010,35(6): 635-641.
    [24]
    Hadjipavlou A G,Mader J T,Necessary J T,et al. Hematogenous pyogenic spinal infections and their surgical management[J]. Spine (Phila Pa 1976),2000,25(13): 1668-1679.
    [25]
    Berbari E F,Kanj S S,Kowalski T J,et al. Executive summary: 2015 Infectious Diseases Society of America (IDSA) clinical practice guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults[J]. Clin Infect Dis,2015,61(6):859-863. doi: 10.1093/cid/civ633
    [26]
    Guo W,Wang M,Chen G,et al. Early surgery with antibiotic medication was effective and efficient in treating pyogenic spondylodiscitis[J]. BMC Musculoskelet Disord,2021,22(1):288. doi: 10.1186/s12891-021-04155-2
    [27]
    Li Y D,Wong C B,Tsai T T,et al. Appropriate duration of post-surgical intravenous antibiotic therapy for pyogenic spondylodiscitis[J]. BMC Infect Dis,2018,18(1):468. doi: 10.1186/s12879-018-3377-1
    [28]
    Rezai A R,Woo H H,Errico T J,et al. Contemporary management of spinal osteomyelitis[J]. Neurosurgery,1999,44(5):1018-1025. doi: 10.1097/00006123-199905000-00047
    [29]
    Menon V K,Kumar K M,Al Ghafri K. One-stage biopsy,debridement,reconstruction,and stabilization of pyogenic vertebral osteomyelitis[J]. Global Spine J,2014,4(2):93-100. doi: 10.1055/s-0034-1370789
    [30]
    Haaker R G,Senkal M,Kielich T,et al. Percutaneous lumbar discectomy in the treatment of lumbar discitis[J]. Eur Spine J,1997,6(2):98-101. doi: 10.1007/BF01358740
    [31]
    Iwata A,Ito M,Abumi K,et al. Fungal spinal infection treated with percutaneous posterolateral endoscopic surgery[J]. J Neurol Surg A Cent Eur Neurosurg,2014,75(3):170-176.
    [32]
    Yang S C,Fu T S,Chen H S,et al. Minimally invasive endoscopic treatment for lumbar infectious spondylitis: A retrospective study in a tertiary referral center[J]. BMC Musculoskelet Disord,2014,27(15):105.
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