The Effect of Bronchoalveolar Lavage Combined with Low Molecular Weight Heparin on Patients with Severe Pneumonia

Yang ZENG; Qian WANG; Maoliang TIAN

doi:10.12259/j.issn.2095-610X.S20240523

Volume 45 Issue 5

May 2024

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Yang ZENG, Qian WANG, Maoliang TIAN. The Effect of Bronchoalveolar Lavage Combined with Low Molecular Weight Heparin on Patients with Severe Pneumonia[J]. Journal of Kunming Medical University, 2024, 45(5): 151-156. doi: 10.12259/j.issn.2095-610X.S20240523

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Yang ZENG, Qian WANG, Maoliang TIAN. The Effect of Bronchoalveolar Lavage Combined with Low Molecular Weight Heparin on Patients with Severe Pneumonia[J]. Journal of Kunming Medical University, 2024, 45(5): 151-156. doi: 10.12259/j.issn.2095-610X.S20240523

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The Effect of Bronchoalveolar Lavage Combined with Low Molecular Weight Heparin on Patients with Severe Pneumonia

doi: 10.12259/j.issn.2095-610X.S20240523

1.
Dept. of Respiratory Medicine and Critical Care Medicine
2.
Dept. of Health Management，Zigong 1st People’s Hospital，Zigong Sichuan 643000，China

Received Date: 2024-01-15
Available Online: 2024-04-29
Publish Date: 2024-05-31

Abstract

Abstract

Objective To analyze the effect of bronchoalveolar lavage combined with low molecular weight heparin on the prognosis with prone ventilation due severe pneumonia. Methods 102 patients with the severe pneumonia from hospitals from January 2021 to January 2023 were selected as the study subjects and randomly divided into a control group （51 cases, conventional treatment+low molecular weight heparin） and a study group （51 cases, conventional treatment+low molecular weight heparin+bronchoalveolar lavage） using a random number table method. Blood gas indexes [blood oxygen saturation （SaO₂）, partial arterial oxygen pressure （PaO₂）, partial arterial carbon dioxide pressure （PaCO₂）], respiratory dynamics indexes [respiratory work done （WOB）, airway resistance （Raw）, dynamic compliance （Cdyn）], pulmonary function indexes [forced vital capacity （FVC）, 1 second maximum expiratory volume （FEV1）, maximum expiratory flow rate （PEF）], inflammatory factors [tumor necrosis factor-α （TNF-α）, interleukin-6 （IL-6）, interleukin-8 （IL-8）], and D-dimer levels before and the first week of treatment were compared between the two groups. And the incidence of adverse prognosis （death, ICU admission, intubation and invasive ventilator） was calculated in the two groups. Results After one week of the treatment, the levels of SaO₂ and PaO₂ in the study group were higher than those in the control group, while PaCO₂ was lower than those in the control group （t = 4.649, 3.774, 4.792, P < 0.05）; After one week of the treatment, the WOB and Raw levels in the study group were lower than those in the control group, while the Cdyn levels were higher than those in the control group （t = 7.207, 5.401, 3.150, P < 0.05）; After one week of the treatment, the FVC, FEV1, and PEF in the study group were higher than those in the control group （t = 3.834, 3.960, 3.908, P < 0.05）; After one week of the treatment, the study group had TNF- α、 The levels of IL-6, IL-8, and D-dimer in the control group were lower than those in the control group （t = 5.642、5.002、6.712、4.127, P < 0.05）; The incidence of poor prognosis in the study group was lower than that in the control group （χ²=4.547, P < 0.05）. Conclusion Bronchoalveolar lavage, combined with low molecular weight heparin, can shorten the duration of clinical symptom disappearance and hospital stay, improve the blood gas indexes, respiratory dynamics, enhance lung function and reduce the level of inflammatory factors in patients with severe pneumonia.
- Severe pneumonia,
- Prone position ventilation,
- Bronchoalveolar lavage,
- Low molecular weight heparin,
- Disease outcome

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