Pan-Cancer Analysis for the Effects of ANGPT1 and TEK on Human Tumor Progression

Guoqing DU; Zhiqin LIU; Yao LI; Yonghua SHI

doi:10.12259/j.issn.2095-610X.S20240608

Volume 45 Issue 6

Jul. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(6): 57-68

Guoqing DU, Zhiqin LIU, Yao LI, Yonghua SHI. Pan-Cancer Analysis for the Effects of ANGPT1 and TEK on Human Tumor Progression[J]. Journal of Kunming Medical University, 2024, 45(6): 57-68. doi: 10.12259/j.issn.2095-610X.S20240608

Citation:

Guoqing DU, Zhiqin LIU, Yao LI, Yonghua SHI. Pan-Cancer Analysis for the Effects of ANGPT1 and TEK on Human Tumor Progression[J]. Journal of Kunming Medical University, 2024, 45(6): 57-68. doi: 10.12259/j.issn.2095-610X.S20240608

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Pan-Cancer Analysis for the Effects of ANGPT1 and TEK on Human Tumor Progression

doi: 10.12259/j.issn.2095-610X.S20240608

Guoqing DU¹,
Zhiqin LIU¹,
Yao LI¹,
Yonghua SHI^{1, 2
,
,}

1.
School of Basic Medical Sciences，Xinjiang Medical University，Urumqi Xinjiang 830017
2.
Xinjiang Key Laboratory of Molecular Biology for Endemic Dieases，Urumqi Xinjiang 830017，China

Received Date: 2023-12-10
Available Online: 2024-05-19
Publish Date: 2024-06-25

Abstract

Abstract

Objective To probe the expression level, prognostic value, and immune invasion of angipoietin-1 （ANGPT1）and its receptor tyrosine kinase （TEK）in pan-cancer. Methods TIMER2.0、Kaplan-Meier plotter and UALCAN etc. databases were used to analyze the expression, prognostic value of ANGPT1 and TEK in various types of tumors. SangerBox 3.0 and R software were used to analyze the relationship between ANGPT1 and TEK tumor mutational burden （TMB）, microsatellite instability （MSI）, immune checkpoint （ICP） and immune cell infiltration. String database, GO and KEGG analysis were used to identify proteins and regulatory pathways related to ANGPT1 and TEK. Results ANGPT1 and TEK showed low expression in most tumors （P < 0.05）. Patients with low expression of ANGPT1 and TEK had a worse prognosis （P < 0.05）. The expression levels of ANGPT1 and TEK were correlated with the clinical stages of clear cell renal carcinoma, bladder urothelial carcinoma, and invasive breast carcinoma （P < 0.05）. The expression of ANGPT1 and TEK was significantly correlated with TMB, MSI and ICP in various tumors （P < 0.05）, and was significantly positively correlated with immune invasion （P < 0.05）. The genes were closely related to ANGPT1 and TEK include GRB2, PIK3R1, EGFR, etc., which were mainly involved in a series of biological processes and functions related to Grb2-EGFR, ERBB3:ERBB2, Shc-EGFR and other complexes, mainly involved ErbB signaling pathway. Conclusion ANGPT1 and TEK may play an important role in tumorigenesis and development through the ErbB signaling pathway, and are expected to be potential clinical prognostic markers for various types of cancer.
- ANGPT1,
- TEK,
- Pan-cancer analysis,
- The R Programming Language

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References(30)

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