Preparation and in Vitro-in Vivo Evaluation of Aspirin Enteric-coated Tablets

Liping DUAN; Xiaoxue CHEN; Zhi YANG; Yinshuang WU; Junyu LIU; Di JIN

doi:10.12259/j.issn.2095-610X.S20240609

Volume 45 Issue 6

Jul. 2024

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Liping DUAN, Xiaoxue CHEN, Zhi YANG, Yinshuang WU, Junyu LIU, Di JIN. Preparation and in Vitro-in Vivo Evaluation of Aspirin Enteric-coated Tablets[J]. Journal of Kunming Medical University, 2024, 45(6): 69-74. doi: 10.12259/j.issn.2095-610X.S20240609

Citation:

Liping DUAN, Xiaoxue CHEN, Zhi YANG, Yinshuang WU, Junyu LIU, Di JIN. Preparation and in Vitro-in Vivo Evaluation of Aspirin Enteric-coated Tablets[J]. Journal of Kunming Medical University, 2024, 45(6): 69-74. doi: 10.12259/j.issn.2095-610X.S20240609

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Preparation and in Vitro-in Vivo Evaluation of Aspirin Enteric-coated Tablets

doi: 10.12259/j.issn.2095-610X.S20240609

Liping DUAN^{1, 2
,},
Xiaoxue CHEN^{1, 2},
Zhi YANG^{1, 2},
Yinshuang WU^{1, 2},
Junyu LIU^{1, 2},
Di JIN^{1, 2}

1.
Yunnan Institute of Medicine，Kunming Yunnan 650100
2.
Yunnan Province Company Key Laboratory for TCM and Ethnic Drug of New Drug Creation，Kunming Yunnan 650100，China

Received Date: 2024-03-28
Available Online: 2024-05-23
Publish Date: 2024-06-25

Abstract

Abstract

Objective To prepare aspirin enteric-coated tablets and investigate its in vitro - in vivo release characteristics. Methods The powder was directly pressed into tablets, and a coating solution with a solid content of 20% was prepared with the aqueous dispersion of enteric-coated material L30D-55, talcum powder and triethyl citrate （1∶1∶0.1） for enteric coating, and the weight gain ranged from 15% to 20%, so that 0.1 g aspirin enteric-coated tablets were prepared, that is, the self-made preparation （T）. Taking 0.1 g （Bayaspirin^®） enteric-coated tablets （R） as reference preparation, the in vitro release and in vivo postprandial pharmacokinetics of the two preparations were investigated. Results The f₂ factor of the in vitro release curves of T and R was greater than 50; C_max, AUC_0-t and AUC_0-∞ of acetylsalicylic acid all meet the corresponding RSABE or ABE bioequivalence evaluation criteria. Conclusion There is a good consistency between the in vitro release of T and R and the postprandial pharmacokinetics in vivo.
- Aspirin enteric-coated tablets,
- Evaluation in vitro-in vivo,
- Bioequiavailability,
- Highly variable drug

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References(18)

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