Study on Influencing Factors of Cognitive Impairment in Late-life Depression Patients

Yuanjia TAO; Yuqi CHENG; Hezhi YAN; Xiangyu SU; Xianyu CHEN; Hongyan JIANG

doi:10.12259/j.issn.2095-610X.S20240612

Volume 45 Issue 6

Jul. 2024

Turn off MathJax

Article Contents

Article Navigation > Journal of Kunming Medical University > 2024 > 45(6): 94-99

Yuanjia TAO, Yuqi CHENG, Hezhi YAN, Xiangyu SU, Xianyu CHEN, Hongyan JIANG. Study on Influencing Factors of Cognitive Impairment in Late-life Depression Patients[J]. Journal of Kunming Medical University, 2024, 45(6): 94-99. doi: 10.12259/j.issn.2095-610X.S20240612

Citation:

Yuanjia TAO, Yuqi CHENG, Hezhi YAN, Xiangyu SU, Xianyu CHEN, Hongyan JIANG. Study on Influencing Factors of Cognitive Impairment in Late-life Depression Patients[J]. Journal of Kunming Medical University, 2024, 45(6): 94-99. doi: 10.12259/j.issn.2095-610X.S20240612

Citation:

PDF( 589 KB)

Study on Influencing Factors of Cognitive Impairment in Late-life Depression Patients

doi: 10.12259/j.issn.2095-610X.S20240612

Dept.of Psychiatry，The 1st Affiliated Hospital of Kunming Medical University，Kunming Yunnan 650031，China

Received Date: 2024-02-27
Available Online: 2024-05-23
Publish Date: 2024-06-25

Abstract

Abstract

Objective To explore the influencing factors of cognitive impairment in elderly patients with depressive disorder. Methods 119 elderly patients with depression were recruited in the 1st Affiliated Hospital of Kunming Medical University. MoCA was used to evaluate the cognitive function of the patients, and a regression model was established to analyze the influencing factors of cognitive impairment in elderly patients with depression. Results Age had a significant effect on the total score of cognition, visuospatial ability, executive function and language function （P < 0.05）. The degree of anxiety had a significant effect on the total score of cognition, visuospatial ability, executive function, attention and working memory （P < 0.05）. Dyslipidemia had a statistically significant effect on the total score of cognition, visuospatial ability and executive function （P < 0.05）. The past medical history had a significant effect on the total score of cognition and language function （P < 0.05）. The sex, onset time, degree of depression, ApoE gene, occupation status and psychotic symptoms had statistically significant effects on individual cognitive function （P < 0.05）. Conclusion Patients with late-life depressive disorder have obvious cognitive impairment. Age, anxiety, dyslipidemia, and past medical history may be the risk factors for cognitive impairment in elderly patients with depressive disorder.
- Late-life depression,
- Cognitive impairment,
- ApoE gene

FullText(HTML)

References(20)

References

[1]	Huang Y,Y Wang,H Wang,et al. Prevalence of mental disorders in China: A cross-sectional epidemiological study[J]. Lancet Psychiatry,2019,6(3):211-224. doi: 10.1016/S2215-0366(18)30511-X
[2]	Baba H,S Kito,K Nukariya,et al. Guidelines for diagnosis and treatment of depression in older adults: A report from the Japanese Society of mood disorders[J]. Psychiatry Clin Neurosci,2022,76(6):222-234. doi: 10.1111/pcn.13349
[3]	王永军,孙丽丽,贾建军. 老年抑郁症与认知功能障碍研究进展[J]. 中华老年心脑血管病杂志,2019,21(7):777-779. doi: 10.3969/j.issn.1009-0126.2019.07.028
[4]	朱贺,殷实. 认知障碍与抑郁症关系的研究进展[J]. 实用老年医学,2023,37(3):234-237. doi: 10.3969/j.issn.1003-9198.2023.03.006
[5]	Shevlin M,P Hyland,S Butter,et al. The development and initial validation of self-report measures of ICD-11 depressive episode and generalized anxiety disorder: The International Depression Questionnaire (IDQ) and the International Anxiety Questionnaire (IAQ)[J]. J Clin Psychol,2023,79(3):854-870. doi: 10.1002/jclp.23446
[6]	Melikyan Z A,M Malek-Ahmadi,K O'Connor,et al. Norms and equivalences for MoCA-30,MoCA-22,and MMSE in the oldest-old[J]. Aging Clin Exp Res,2021,33(12):3303-3311. doi: 10.1007/s40520-021-01886-z
[7]	曹新妹. 常用心理卫生评定量表的评定技术[J]. 上海护理,2011,11(5):91-96. doi: 10.3969/j.issn.1009-8399.2011.05.034
[8]	Smith T, Gildeh N, Holmes C. The Montreal Cognitive Assessment: Validity and utility in a memory clinic setting[J]. Can J Psychiatry,2007,52(5):329-332.
[9]	Conradi H J,J Ormel,P de Jonge. Presence of individual (residual) symptoms during depressive episodes and periods of remission: A 3-year prospective study[J]. Psychol Med,2011,41(6):1165-1174. doi: 10.1017/S0033291710001911
[10]	Yang A N,X L Wang,H R Rui,et al. Neuropsychiatric symptoms and risk factors in mild cognitive impairment: A cohort investigation of elderly patients[J]. J Nutr Health Aging,2020,24(2):237-241. doi: 10.1007/s12603-020-1312-9
[11]	Muhammad T,T Meher. Association of late-life depression with cognitive impairment: Evidence from a cross-sectional study among older adults in India[J]. BMC Geriatr,2021,21(1):364-376. doi: 10.1186/s12877-021-02314-7
[12]	Keilp J G,S P Madden,M Gorlyn,et al. The lack of meaningful association between depression severity measures and neurocognitive performance[J]. J Affect Disord,2018,241(34):164-172.
[13]	Szymkowicz S M,V M Dotson,R D Vanderploeg. Weak associations between depressive symptom severity,depressive symptom clusters,and cognitive performance in young to middle-aged men without clinical depression[J]. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn,2021,28(6):921-935. doi: 10.1080/13825585.2020.1840505
[14]	郑涵. 欧洲中老年人抑郁轨迹与认知功能的关系研究[D]. 济南: 山东大学,2021.
[15]	Stern Y,E M Arenaza-Urquijo,D Bartr é s-Faz,et al. Whitepaper: Defining and investigating cognitive reserve,brain reserve,and brain maintenance[J]. Alzheimers Dement,2020,16(9):1305-1311. doi: 10.1016/j.jalz.2018.07.219
[16]	Assuncao N,F K Sudo,C Drummond,et al. Metabolic Syndrome and cognitive decline in the elderly: A systematic review[J]. PLoS One,2018,13(3):e0194990. doi: 10.1371/journal.pone.0194990
[17]	Luchsinger J A,N Younes,J J Manly,et al. Association of glycemia,lipids,and blood pressure with cognitive performance in people with type 2 diabetes in the glycemia reduction approaches in diabetes: A comparative effectiveness study (GRADE)[J]. Diabetes Care,2021,44(10):2286-2292. doi: 10.2337/dc20-2858
[18]	Tsang R S,K A Mather,P S Sachdev,et al. Systematic review and meta-analysis of genetic studies of late-life depression[J]. Neurosci Biobehav Rev,2017,75(3):129-139.
[19]	Fan P L,C D Chen,W T Kao,et al. Protective effect of the apo epsilon2 allele in major depressive disorder in Taiwanese[J]. Acta Psychiatr Scand,2006,113(1):48-53. doi: 10.1111/j.1600-0447.2005.00686.x
[20]	Szymkowicz S M,C Ryan,D M Elson,et al. Cognitive phenotypes in late-life depression[J]. Int Psychogeriatr,2023,35(4):193-205. doi: 10.1017/S1041610222000515

Relative Articles(20)

Relative Articles

[1]	Qinghua YI, Juan XU, Ailian LI, Linyun TIAN, Dongli SANG, Jing XIONG, Chang DENG. Association between Body Mass Index and Cognitive Impairment in the Elderly in Guandu District of Kunming City. Journal of Kunming Medical University, 2024, 45(10): 122-129. doi: 10.12259/j.issn.2095-610X.S20241019
[2]	Zhaosong CHU, Xin WANG, Mengxin HE, Xiufeng XU, Na WANG, Zonglin SHEN. Research Progress on Gene Related to Suicide in Major Depressive Disorder：A Review. Journal of Kunming Medical University, 2023, 44(3): 143-148. doi: 10.12259/j.issn.2095-610X.S20230301
[3]	Yao HUANG, Xi LI, Bo YAN, Lei LEI, Zegang YIN, Jin FAN, Peng BAI. Correlation between Internal Carotid Artery Stenosis and Cognitive Impairment. Journal of Kunming Medical University, 2023, 44(1): 70-75. doi: 10.12259/j.issn.2095-610X.S20230105
[4]	Xian LI, Chang-liang JI, Shu-e ZENG, Shu-yun YANG, Hao-qi YANG, Ya-ting HOU. A Comparative Study of the Cognitive Function in Patients with Different Degrees of Depression. Journal of Kunming Medical University, 2020, 41(12): 94-98. doi: 10.12259/j.issn.2095-610X.S20201226
[5]	Wang Ru Jiao , Zhang Ling , Yang Ji Ying , Zhou Qiang , Sun Feng Qin , Zhang Yu Lin , Huang Wei . . Journal of Kunming Medical University, 2020, 41(01): 68-72.
[6]	Ge A, Xiao-yan LIU, Li LIU, Yu-jia ZHAN, Ting-ting TANG, Jingnan TAO. Family Burden in Elderly Hip Fracture Patients with Cognitive Impairment and Its Influencing Factors. Journal of Kunming Medical University, 2020, 41(12): 168-172. doi: 10.12259/j.issn.2095-610X.S20201246
[7]	Zhang Xu Xiang , Li Wen , Wang Fang , Lin Meng Jie , Li Hong , Zhang Li , Nian Xin . . Journal of Kunming Medical University, 2020, 41(05): 18-22.
[8]	Li Yun Ling , Bao Tian Hao , Zhang Ya Zhou , Tian Wei Meng , Mao Wen Wen , Hu Xiao Yun , Li Hua , Gu Jun . . Journal of Kunming Medical University, 2019, 40(07): 69-73.
[9]	Yang Jie , Yi Zhi Kai , Li Na . . Journal of Kunming Medical University, 2018, 39(09): 22-26.
[10]	Han Juan , Xu Hong . . Journal of Kunming Medical University, 2018, 39(10): 68-71.
[11]	Li Ming . Curative Effect of Computer Assisted Cognitive Rehabilitation System for Cognitive Impairment after Stroke. Journal of Kunming Medical University,
[12]	Bao Juan . . Journal of Kunming Medical University,
[13]	Cai Ya Mei . . Journal of Kunming Medical University,
[14]	Wang Hong . . Journal of Kunming Medical University,
[15]	Du Ying Rong . . Journal of Kunming Medical University,
[16]	Li Gui Fen . . Journal of Kunming Medical University,
[17]	Wang Hong . . Journal of Kunming Medical University,
[18]	Liu Shu Qing . . Journal of Kunming Medical University,
[19]	Zhao Xiao Hong . . Journal of Kunming Medical University,
[20]	Cao Lan . Misdiagnosis of Mesenteric Panniculitis as Colonic Tumor: A Report of 4 Cases. Journal of Kunming Medical University,