Individualized Numerical Simulation of Blood Flow in Stanford Type A Aortic Dissection

Zhenkun YU; Kang LIU; Hua LIN; Beibei WANG; Hongming ZHANG; Jianming XIA

doi:10.12259/j.issn.2095-610X.S20240613

Volume 45 Issue 6

Jul. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(6): 100-105

Zhenkun YU, Kang LIU, Hua LIN, Beibei WANG, Hongming ZHANG, Jianming XIA. Individualized Numerical Simulation of Blood Flow in Stanford Type A Aortic Dissection[J]. Journal of Kunming Medical University, 2024, 45(6): 100-105. doi: 10.12259/j.issn.2095-610X.S20240613

Citation:

Zhenkun YU, Kang LIU, Hua LIN, Beibei WANG, Hongming ZHANG, Jianming XIA. Individualized Numerical Simulation of Blood Flow in Stanford Type A Aortic Dissection[J]. Journal of Kunming Medical University, 2024, 45(6): 100-105. doi: 10.12259/j.issn.2095-610X.S20240613

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Individualized Numerical Simulation of Blood Flow in Stanford Type A Aortic Dissection

doi: 10.12259/j.issn.2095-610X.S20240613

1.
Dept.of Cardiovascular Surgery，Fuwai Yunnan Cardiovascular Hospital，Kunming Yunnan 650102
2.
Dept.of Cardiovascular Surgery，Yan’an Hospital of Kunming City，Kunming Yunnan 650051
3.
Biomedical Engineering Research Institute of Kunming Medical University，Kunming Yunnan 650500
4.
Dept.of Cardiovascular Surgery，Changhai Hospital, Second Military Medical University，Shanghai 200082
5.
Kunming University of Science and Technology，Kunming Yunnan 650500，China

Received Date: 2024-02-24
Available Online: 2024-05-23
Publish Date: 2024-06-25

Abstract

Abstract

Objective To investigate the hemodynamic changes after the occurrence of Stanford type A aortic dissection. Methods Computed tomography angiography（CTA） images of the aorta were collected from 4 Stanford A type aortic dissection patients and 2 healthy volunteers, and the three-dimensional models of the aorta were established and meshed. The above models were numerically simulated by fluid simulation software. Results The blood flow in the aorta of healthy volunteers was approximately laminar. The blood flow field in the true lumen was approximately laminar. Turbulence not only occurred near the intimal tear of the true lumen, but also near the area where the false lumen compressed the true lumen. The wall pressure of the true lumen was higher than that of the false lumen. During the systolic phase, the peak wall pressure of the false lumen was located at the primary entry tear of the dissection, the high wall shear stress appeared around the true lumen compressed by false lumen and the tear of false lumen. Moreover, stress concentration occurred at the intimal tear. Compared to aortic dissection with a single tear, aortic dissection with two tears exhibited lower wall shear stress around the intimal tear. Conclusion Individualized computational fluid dynamics analysis can provide reference for personalized diagnosis and treatment of aortic dissection.
- Computational fluid dynamics,
- Hemodynamics,
- Numerical simulation,
- Aortic dissection

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References(17)

References

[1]	Takahashi K,Sekine T,Miyagi Y,et al. Four-dimensional flow analysis reveals mechanism and impact of turbulent flow in the dissected aorta[J]. Eur J Cardiothorac Surg,2021,60(5):1064-1072. doi: 10.1093/ejcts/ezab201
[2]	Marlevi D,Ruijsink B,Balmus M,et al. Estimation of cardiovascular relative pressure using virtual work-energy[J]. Sci Rep,2019,9(1):1375. doi: 10.1038/s41598-018-37714-0
[3]	Zhu Y,Xu X Y,Rosendahl U,et al. Advanced risk prediction for aortic dissection patients using imaging-based computational flow analysis[J]. Clin Radiol,2023,78(3):e155-e165. doi: 10.1016/j.crad.2022.12.001
[4]	Osswald A,Karmonik C,Anderson J R,et al. Elevated wall shear stress in aortic type B dissection may relate to retrograde aortic type A dissection: A computational fluid dynamics pilot study[J]. Eur J Vasc Endovasc Surg,2017,54(3):324-330. doi: 10.1016/j.ejvs.2017.06.012
[5]	Zhu Y,Lingala B,Baiocchi M,et al. Type A aortic Dissection-experience over 5 decades: JACC historical breakthroughs in perspective[J]. J Am Coll Cardiol,2020,76(14):1703-1713. doi: 10.1016/j.jacc.2020.07.061
[6]	韩涵,郭宝磊,孙翠茹,等. 主动脉夹层裂纹面内扩展的数值模拟[J]. 医用生物力学,2023,38(3):479-486.
[7]	Madhavan S,Kemmerling E M C. The effect of inlet and outlet boundary conditions in image-based CFD modeling of aortic flow[J]. Biomed Eng Online,2018,17(1):66. doi: 10.1186/s12938-018-0497-1
[8]	Alimohammadi M,Agu O,Balabani S,et al. Development of a patient-specific simulation tool to analyse aortic dissections: assessment of mixed patient-specific flow and pressure boundary conditions[J]. Med Eng Phys,2014,36(3):275-284. doi: 10.1016/j.medengphy.2013.11.003
[9]	Williams J G,Marlevi D,Bruse J L,et al. Aortic dissection is determined by specific shape and hemodynamic interactions[J]. Ann Biomed Eng,2022,50(12):1771-1786. doi: 10.1007/s10439-022-02979-0
[10]	Chi Q,He Y,Luan Y,et al. Numerical analysis of wall shear stress in ascending aorta before tearing in type A aortic dissection[J]. Comput Biol Med,2017,89(10):236-247. doi: 10.1016/j.compbiomed.2017.07.029
[11]	Sun W,Zheng J,Gao Y. Targeting platelet activation in abdominal aortic aneurysm: Current knowledge and perspectives[J]. Biomolecules,2022,12(2):206. doi: 10.3390/biom12020206
[12]	Spinelli D,Benedetto F,Donato R,et al. Current evidence in predictors of aortic growth and events in acute type B aortic dissection[J]. J Vasc Surg,2018,68(6): 1925-1935. e8.
[13]	柏亚明. Stanford A型主动脉夹层数值模拟研究的初步探讨[D]. 昆明:昆明医科大学,2022.
[14]	王仕奇,王凌云,林志鸿,等. 基于计算流体力学的个性化Stanford B型主动脉夹层血流动力学研究[J/OL]. 中国胸心血管外科临床杂志,2024,31(4):594-599.
[15]	Qiao Y,Zeng Y,Ding Y,et al. Numerical simulation of two-phase non-Newtonian blood flow with fluid-structure interaction in aortic dissection[J]. Comput Methods Biomech Biomed Engin,2019,22(6):620-630. doi: 10.1080/10255842.2019.1577398
[16]	Armour C H,Guo B,Saitta S,et al. Evaluation and verification of patient-specific modelling of type B aortic dissection[J]. Comput Biol Med,2022,140(1):105053. doi: 10.1016/j.compbiomed.2021.105053
[17]	Pirola S,Guo B,Menichini C,et al. 4-D Flow MRI-based computational analysis of blood flow in patient-specific aortic dissection[J]. IEEE Trans Biomed Eng,2019,66(12):3411-3419. doi: 10.1109/TBME.2019.2904885

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