Analysis of PTH and ER Gene Polymorphisms in Patients with Type 2 Diabetes Mellitus Complicated with Osteoporosis

Ling NIU; Rong MA; Cheng ZHANG; Cuijuan MIAO; Yan TANG; Fang LIU; Boyi LI

doi:10.12259/j.issn.2095-610X.S20240614

Volume 45 Issue 6

Jul. 2024

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Ling NIU, Rong MA, Cheng ZHANG, Cuijuan MIAO, Yan TANG, Fang LIU, Boyi LI. Analysis of PTH and ER Gene Polymorphisms in Patients with Type 2 Diabetes Mellitus Complicated with Osteoporosis[J]. Journal of Kunming Medical University, 2024, 45(6): 106-112. doi: 10.12259/j.issn.2095-610X.S20240614

Citation:

Ling NIU, Rong MA, Cheng ZHANG, Cuijuan MIAO, Yan TANG, Fang LIU, Boyi LI. Analysis of PTH and ER Gene Polymorphisms in Patients with Type 2 Diabetes Mellitus Complicated with Osteoporosis[J]. Journal of Kunming Medical University, 2024, 45(6): 106-112. doi: 10.12259/j.issn.2095-610X.S20240614

Citation:

Ling NIU, Rong MA, Cheng ZHANG, Cuijuan MIAO, Yan TANG, Fang LIU, Boyi LI. Analysis of PTH and ER Gene Polymorphisms in Patients with Type 2 Diabetes Mellitus Complicated with Osteoporosis[J]. Journal of Kunming Medical University, 2024, 45(6): 106-112. doi: 10.12259/j.issn.2095-610X.S20240614

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Analysis of PTH and ER Gene Polymorphisms in Patients with Type 2 Diabetes Mellitus Complicated with Osteoporosis

doi: 10.12259/j.issn.2095-610X.S20240614

Dept. of Endocrinology and Clinical Laboratory，The 1st People’s Hospital of Kunmig，Kunming Yunnan 650011，China

Received Date: 2024-03-03
Available Online: 2024-05-24
Publish Date: 2024-06-25

Abstract

Abstract

Objective To investigate the characteristics of parathyroid hormone （PTH） and estrogen receptor （ER） gene polymorphisms in patients with type 2 diabetes mellitus （T2DM） complicated with osteoporosis （OP）. Methods 110 patients with T2DM from Kunming area were selected in the 1st People’ s Hospital of Kunming Endocrinology Department from November 2022 to October 2023, and were divided into T2DM without OP group（n = 68, T≥-1.0）, T2DM with OP group（n = 42, T≤-2.5）, according to the results of bone mineral density , the genotype and allele frequency of PTH and ER were detected, and the differences between them and gender, height, weight and other clinical indicators were compared. Results Regression analysis showed that T2DM with OP was related to gende and weight （P < 0.05）, but not related to PTH gene, or ER gene polymorphism （P > 0.05）. Conclusion Gender and weight are independent risk factors for osteoporosis in patients with type 2 diabetes mellitus; gene polymorphism of PTH and ER are not related to the genetic susceptibility of T2DM with OP in Kunming area.
- gene polymorphism,
- type 2 diabetes mellitus,
- osteoporosis

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References(22)

References

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