Volume 45 Issue 6
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Citation: Ji WANG, Songtao BIN, Li TAN. Study on the Efficacy of Acetylcysteine in Severe Pneumonia in Children under Electronic Bronchoscopy[J]. Journal of Kunming Medical University, 2024, 45(6): 113-119. doi: 10.12259/j.issn.2095-610X.S20240615
shu

Study on the Efficacy of Acetylcysteine in Severe Pneumonia in Children under Electronic Bronchoscopy

doi: 10.12259/j.issn.2095-610X.S20240615

  • Dept. of Respiratory Medicine，Kunming Children’s Hospital，Kunming Yunnan 650031，China

  • Received Date: 2024-02-21
    Available Online: 2024-05-23
  • Publish Date: 2024-06-25
    Abstract
  •   Objective  To explore the clinical efficacy of acetylcysteine solution retained perfusion inhalation treatment under electronic bronchoscopy in children with severe bacterial pneumonia.   Methods  From January 1, 2021 to December 31, 2022, 86 children with severe bacterial pneumonia treated in the Department of Respiratory Medicine of Kunming Children’ s Hospital were randomly divided into a control group （n = 43） and a study group （n = 43）. The children in the control group received electronic bronchoscopy under physiological saline pulmonary alveolar lavage treatment. The study group received acetylcysteine solution treatment retained after the end of the pulmonary lavage treatment. The clinical treatment effects, inflammatory indicators, tidal breathing function, and adverse reactions of the two groups were compared.   Results  After treatment, compared with control group, the hospitalization time, cough disappearance time and comorbidities disappearance time of children in study group were significantly shortened （P < 0.05）, and the total effective rate of study group was significantly higher than that of control group （P < 0.05）. The levels of white blood cell count, procalcitonin, C-reactive protein, interleukin-6, and tumor necrosis factor-α of study group were significantly lower than those of control group （P < 0.05）. The tidal volume per kilogram of body weight, peak time ratio, and peak volume ratio levels of study group were significantly higher than those of control group （P < 0.05）.There was no statistically significant difference in the adverse drug reactions between two groups （P > 0.05）.   Conclusion  Under electronic bronchoscopy, preserving perfusion and inhaling acetylcysteine solution can significantly improve the clinical symptoms, inflammatory indicators, and lung function of children with severe bacterial pneumonia, and it is relatively safe.
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