Analysis of the Efficacy and Safety of GM1 Injection Combined with Batroxobin in the Treatment of Sudden Deafness Patients

Liyuan YUN; Junfeng WANG; Ning GUO; Ruimei DING; Haipeng LI; Xueping ZHANG

doi:10.12259/j.issn.2095-610X.S20240619

Volume 45 Issue 6

Jul. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(6): 140-144

Liyuan YUN, Junfeng WANG, Ning GUO, Ruimei DING, Haipeng LI, Xueping ZHANG. Analysis of the Efficacy and Safety of GM1 Injection Combined with Batroxobin in the Treatment of Sudden Deafness Patients[J]. Journal of Kunming Medical University, 2024, 45(6): 140-144. doi: 10.12259/j.issn.2095-610X.S20240619

Citation:

Liyuan YUN, Junfeng WANG, Ning GUO, Ruimei DING, Haipeng LI, Xueping ZHANG. Analysis of the Efficacy and Safety of GM1 Injection Combined with Batroxobin in the Treatment of Sudden Deafness Patients[J]. Journal of Kunming Medical University, 2024, 45(6): 140-144. doi: 10.12259/j.issn.2095-610X.S20240619

Citation:

Liyuan YUN, Junfeng WANG, Ning GUO, Ruimei DING, Haipeng LI, Xueping ZHANG. Analysis of the Efficacy and Safety of GM1 Injection Combined with Batroxobin in the Treatment of Sudden Deafness Patients[J]. Journal of Kunming Medical University, 2024, 45(6): 140-144. doi: 10.12259/j.issn.2095-610X.S20240619

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Analysis of the Efficacy and Safety of GM1 Injection Combined with Batroxobin in the Treatment of Sudden Deafness Patients

doi: 10.12259/j.issn.2095-610X.S20240619

1.
Dept. of Ultrasound
2.
Dept. of Neurology，Affiliated Hospital of Tangshan Vocational and Technical College，Tangshan Hebei 063000，China

Received Date: 2024-01-25
Available Online: 2024-05-23
Publish Date: 2024-06-25

Abstract

Abstract

Objective To investigate the therapeutic efficacy and safety of the combination of monosialotetrahexosylganglioside （GM1） injection and Batroxobin in treating sudden deafness. Methods The clinical data of 162 patients with sudden deafness in Affiliated Hospital of Tangshan Vocational and Technical College between January 2018 and December 2022 were selected for retrospective analysis and grouped according to the treatment protocol, 81 cases in the control group were treated with batroxobin and 81 cases in the observation group were treated with GM1 injection combined with batroxobin. The efficacy and symptom recovery time of the 2 groups were compared, as well as the levels of pure tone hearing threshold, inflammatory indexes [interleukin-10 （IL-10）, high sensitive C-reactive protein （hs-CRP）, and tumor necrosis factor-α （TNF-α）] before and after treatment, and safety. Results The total effective rate of the observation group was 92.59%, which was higher than that of the control group （59.26%）（P < 0.05）; the observation group had shorter time for dizziness to disappear, hearing to return to normal, and tinnitus to disappear than the control group （P < 0.05）; pure tone hearing thresholds in the observation group were lower than those in the control group after 7 d and 14 d of treatment （P > 0.05）; after treatment, the serum IL-10 level in the observation group was higher than that in the control group, while the levels of hs-CRP and TNF-α were lower than those in the control group（P < 0.05）; the incidence of adverse reactions in the observation group was 11.11%, compared with 9.88% in the control group, the difference was not statistically significant （P > 0.05）. Conclusion GM1 injection combined with batroxobin can effectively control the inflammatory response in patients with sudden deafness, improve hearing status, accelerate the recovery process, and has a certain degree of safety and efficacy.
- Sudden deafness,
- Batroxobin,
- GM1 injection,
- Efficacy,
- Safety

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References(17)

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