Effectiveness and Safety Analysis of Cyclopol Combined with Remifentanil in Anesthesia for Endoscopic Gastric Cancer Radical Surgery

Keyan WANG; Bingting LIN; Xiaolin WENG; Bin HUANG; Lie WANG

doi:10.12259/j.issn.2095-610X.S20240621

Volume 45 Issue 6

Jul. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(6): 154-160

Keyan WANG, Bingting LIN, Xiaolin WENG, Bin HUANG, Lie WANG. Effectiveness and Safety Analysis of Cyclopol Combined with Remifentanil in Anesthesia for Endoscopic Gastric Cancer Radical Surgery[J]. Journal of Kunming Medical University, 2024, 45(6): 154-160. doi: 10.12259/j.issn.2095-610X.S20240621

Citation:

Keyan WANG, Bingting LIN, Xiaolin WENG, Bin HUANG, Lie WANG. Effectiveness and Safety Analysis of Cyclopol Combined with Remifentanil in Anesthesia for Endoscopic Gastric Cancer Radical Surgery[J]. Journal of Kunming Medical University, 2024, 45(6): 154-160. doi: 10.12259/j.issn.2095-610X.S20240621

Citation:

Keyan WANG, Bingting LIN, Xiaolin WENG, Bin HUANG, Lie WANG. Effectiveness and Safety Analysis of Cyclopol Combined with Remifentanil in Anesthesia for Endoscopic Gastric Cancer Radical Surgery[J]. Journal of Kunming Medical University, 2024, 45(6): 154-160. doi: 10.12259/j.issn.2095-610X.S20240621

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Effectiveness and Safety Analysis of Cyclopol Combined with Remifentanil in Anesthesia for Endoscopic Gastric Cancer Radical Surgery

doi: 10.12259/j.issn.2095-610X.S20240621

1.
Department of Anesthesiology and Perioperative Medicine，900th Hospital of Joint Logistic Support Force，PLA，Fujian 350001
2.
General surgery， Fuzhou Fujian 350001，China

Received Date: 2023-11-28
Available Online: 2024-02-26
Publish Date: 2024-06-25

Abstract

Abstract

Objective To investigate the effectiveness and safety of cyclophenol combined with remifentanil in anesthesia for laparoscopic radical gastrectomy for gastric cancer. Methods A total of 100 patients who underwent laparoscopic radical gastrectomy for gastric cancer admitted to 900 Hospital of the Joint Logistic Support Force from August 2022 to July 2023 were randomly divided into two groups: the propofol combined with remifentanil group （50 cases） received propofol combined with remifentanil anesthesia, and the cyclopol combined with remifentanil group （50 cases） received cyclophenol combined with remifentanil anesthesia. The vital signs （respiratory rate, heart rate, and blood oxygen saturation） of the two groups of patients were observed. Anesthesia indicators （onset time of anesthesia, recovery time of spontaneous breathing, awakening time, time of leaving the room）, anesthesia effect, and adverse reactions （Injection pain, hypotension, hypoxemia, respiratory depression, dizziness, drowsiness） were also observed. Results The interaction effect of respiratory rate between two groups, time points, and between groups/time points showed no statistically significant difference （P > 0.05）; The interaction between heart rate and blood oxygen saturation between two groups, time points, and between groups and time points showed statistically significant differences （P < 0.05）. There was no statistically significant difference （P > 0.05） in the respiratory rate between the two groups of T0 to T5. The heart rate of T1 and T2 in the combination of propofol and remifentanil group was higher than that in the combination of propofol and remifentanil group, and the difference was statistically significant （P < 0.05）. There was no statistically significant difference in heart rate between the two groups at other times （P > 0.05）. The blood oxygen saturation of T2 in the combination of propofol and remifentanil group was higher than that in the combination of propofol and remifentanil group, and the difference was statistically significant （P < 0.05）. There was no statistically significant difference in blood oxygen saturation between the two groups at other times （P > 0.05）. There was no statistically significant difference in the onset time of anesthesia between the two groups （P > 0.05）. The spontaneous breathing recovery time, awakening time, and departure time of the group treated with propofol combined with remifentanil were shorter than those of the group treated with propofol combined with remifentanil, and the differences were statistically significant （P < 0.05）. The total effective rate of the combination of propofol and remifentanil group was 96.00%, which was higher than the 84.00% of the combination of propofol and remifentanil group, and the difference was statistically significant （P < 0.05）. The incidence of adverse reactions in the combination of propofol and remifentanil group was 10.00%, which was lower than the 28.00% in the combination of propofol and remifentanil group, and the difference was statistically significant （P < 0.05）. Conclusion The application of cyclophorol combined with remifentanil in anesthesia for laparoscopic radical gastrectomy for gastric cancer has a good effect, can stabilize the patient's intraoperative vital signs, improve anesthesia indicators, reduce adverse reactions, and can be promoted.
- Cyclophenol,
- Remifentanil,
- Endoscopic radical gastrectomy for gastric cancer,
- Anesthesia,
- Effectiveness,
- Security

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References(25)

References

[1]	白国强,翟科一,吕兰,等. 椎旁神经阻滞对行腹腔镜根治术治疗胃癌患者麻醉效果的影响[J]. 临床消化病杂志,2022,34(4):253-257. doi: 10.3870/lcxh.j.issn.1005-541X.2022.04.005
[2]	周华,蒋亚坤,张占军,等. 右美托咪定联合纳布啡在腹腔镜胃癌根治术患者中的应用效果[J]. 癌症进展,2023,21(3):338-341.
[3]	杨远胡,李树奇,徐锋. 胃癌根治术患者采用舒芬太尼联合瑞芬太尼的麻醉效果及对应激反应的改善[J]. 中国现代普通外科进展,2020,23(4):316-318.
[4]	廖婷,张彩玲,田文华. 丙泊酚靶控输注复合瑞芬太尼对腹腔镜胃癌根治术患者麻醉效果的影响[J]. 临床医学工程,2020,27(2):165-166. doi: 10.3969/j.issn.1674-4659.2020.02.0165
[5]	刘澳华,赵盼盼,李北平,等. 环泊酚复合瑞芬太尼应用于肥胖患者无痛胃镜麻醉效果分析[J]. 临床和实验医学杂志,2023,22(11):1230-1233.
[6]	郝迎春,曹惠鹃,孙莹杰,等. 环泊酚与丙泊酚用于宫腔镜手术的比较[J]. 临床麻醉学杂志,2023,39(1):106-108.
[7]	朱诗利,吴磊,贺彬,等. 环泊酚复合瑞芬太尼麻醉用于儿童脊髓拴系手术的疗效与安全性探讨[J]. 临床小儿外科杂志,2023,22(6):549-553.
[8]	中华人民共和国国家卫生和计划生育委员会. 胃癌规范化诊疗指南(试行)[J]. 慢性病学杂志,2013,8(8):561-568.
[9]	Apfelbaum J L,Hagberg C A,Connis R T,et al. 2022 American society of anesthesiologists practice guidelines for management of the difficult airway[J]. Anesthesiology,2022,136(1):31-81. doi: 10.1097/ALN.0000000000004002
[10]	李鑫. 丙泊酚靶控输注复合瑞芬太尼对腹腔镜胃癌根治术患者麻醉效果的影响分析[J]. 中国药物与临床,2021,21(14):2501-2503.
[11]	甘璐,葛丽华,石松,等. 纳布啡在老年腹腔镜胃癌根治术患者术后多模式镇痛中的应用[J]. 中国老年学杂志,2023,43(13):3145-3149.
[12]	姚小蓉,杨玲,李花,等. 右美托咪定不同给药方式联合腹横肌平面阻滞对老年患者腹腔镜胃癌根治术术后恢复的影响[J]. 实用药物与临床,2023,26(3):211-215.
[13]	李海英,白延斌. 依托咪酯与丙泊酚对老年胃癌根治术患者皮质醇、醛固酮及丙二醛水平的影响[J]. 陕西医学杂志,2021,50(1):62-64.
[14]	刘婷,吴文华,廖兴志. 丙泊酚在胃癌根治术中应用对患者术后下呼吸道感染、免疫功能的影响[J]. 湖南师范大学学报(医学版),2022,19(1):203-206.
[15]	刘冰,贾凯琪. 丙泊酚对胃癌根治术后下呼吸道感染和免疫功能的影响[J]. 中国现代普通外科进展,2020,23(3):237-239.
[16]	于道阳,郭强. 丙泊酚复合全身麻醉对胃癌手术患者CM-RO2、CBF的影响[J]. 实用癌症杂志,2020,35(11):1864-1867.
[17]	Fan G B,Li Y,Xu G S,et al. Propofol inhibits ferroptotic cell death through the Nrf2/Gpx4 signaling pathway in the mouse model of cerebral ischemia-reperfusion injury[J]. Neurochemical Research,2023,48(3):956-966. doi: 10.1007/s11064-022-03822-7
[18]	邢楚彬. 环泊酚与丙泊酚在老年患者无痛胃镜麻醉中安全性和有效性比较的临床研究[D]. 长春: 吉林大学, 2023.
[19]	张元会,丛仔红. 瑞芬太尼和舒芬太尼靶控输注在老年腹腔镜胃癌根治术中的效果观察[J]. 中国肿瘤临床与康复,2022,29(2):206-209.
[20]	杨晓艳,朱志华,张力强,等. 瑞芬太尼与舒芬太尼靶控输注对老年患者行腹腔镜胃癌根治术麻醉恢复质量的影响[J]. 中国内镜杂志,2020,26(2):48-54.
[21]	李玲瑶,李术榕,李响,等. 环泊酚临床应用现状及研究进展[J]. 心肺血管病杂志,2023,42(1):97-99.
[22]	贾畅,曹惠鹃,孙莹杰,等. 丙泊酚与环泊酚分别复合羟考酮对人流术麻醉效果的随机对照研究[J]. 实用药物与临床,2022,25(11):1012-1015.
[23]	黄凤南,崔珊珊,夏中元,等. 环泊酚单药与丙泊酚联合瑞芬太尼在无痛胃镜检查中的应用效果比较[J]. 山东医药,2022,62(26):79-81.
[24]	Liu Y,Yu X,Zhu D,et al. Safety and efficacy of ciprofol vs propofol for sedation in intensive care unit patients with mechanical ventilation: A multi-center,open label,randomized,phase 2 trial[J]. Chinese Medical Journal,2022,135(9):1043-1051. doi: 10.1097/CM9.0000000000001912
[25]	易强林,莫怀忠,胡慧,等. 环泊酚与丙泊酚在老年患者无痛胃镜检查中的比较[J]. 临床麻醉学杂志,2022,38(7):712-715.

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