Research Progress on The Potential Application of Circular RNA in Systemic Lupus Erythematosus

Li LI; Ruixian ZHANG

doi:10.12259/j.issn.2095-610X.S20240622

Volume 45 Issue 6

Jul. 2024

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Li LI, Ruixian ZHANG. Research Progress on The Potential Application of Circular RNA in Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2024, 45(6): 161-165. doi: 10.12259/j.issn.2095-610X.S20240622

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Li LI, Ruixian ZHANG. Research Progress on The Potential Application of Circular RNA in Systemic Lupus Erythematosus[J]. Journal of Kunming Medical University, 2024, 45(6): 161-165. doi: 10.12259/j.issn.2095-610X.S20240622

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Research Progress on The Potential Application of Circular RNA in Systemic Lupus Erythematosus

doi: 10.12259/j.issn.2095-610X.S20240622

Li LI¹,
Ruixian ZHANG^{2
,
,}

1.
School of Public Health，Dali University，Dali Yunnan 671013
2.
Dept. of Disease Control and Prevention，The 1st People’s Hospital of Yunnan Province，Kunming Yunnan 650034，China

Received Date: 2023-09-22
Available Online: 2024-05-23
Publish Date: 2024-06-25

Abstract

Abstract

Circular RNA （circRNA）, formed by reverse splicing of pre-mRNA, constitutes a closed-loop RNA structure with diversity in molecular characteristics, biological functions, and regulatory mechanisms. In recent years, there has been growing recognition of the roles of circRNA in various human diseases, serving potentially as molecular biomarkers for disease diagnosis and prognosis prediction, including the classical autoimmune disease systemic lupus erythematosus （SLE）. Currently, dysregulated expression of some circRNAs has been observed in SLE, which can promote the occurrence and development of SLE through different mechanisms such as "molecular sponge" effects, modulation of signaling pathways, inhibition of protein kinase activation, and induction of cell apoptosis. Another part may serve as potential clinical biomarkers for SLE, holding translational potential. This paper reviews the research on circRNA in SLE over the past years, aiming to provide scientific evidence and references for subsequent studies on circRNA in SLE.
- Circular RNA,
- Systemic lupus erythematosus,
- Biomarkers,
- Molecular mechanisms

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References(34)

References

[1]	Dolgin E. Why rings of rna could be the next blockbuster drug[J]. Nature,2023,622(7981):22-24. doi: 10.1038/d41586-023-03058-7
[2]	Kristensen L S,Andersen M S,Stagsted L V W,et al. The biogenesis,biology and characterization of circular rnas[J]. Nat Rev Genet,2019,20(11):675-691. doi: 10.1038/s41576-019-0158-7
[3]	娄雪,廖莉,赵若彤,等. 抗dsdna抗体、补体c3及其他实验室指标对于诊断系统性红斑狼疮肾损伤的临床意义[J]. 昆明医科大学学报,2021,42(2):49-53.
[4]	Lazar S,Kahlenberg J M. Systemic lupus erythematosus: New diagnostic and therapeutic approaches[J]. Annu Rev Med,2023,74(1):339-352. doi: 10.1146/annurev-med-043021-032611
[5]	Kour B,Gupta S,Singh R,et al. Interplay between circular rna,microrna,and human diseases[J]. Mol Genet Genomics,2022,297(2):277-286. doi: 10.1007/s00438-022-01856-8
[6]	Abbas A A,Abdulkader H A,Giordo R,et al. Implications and theragnostic potentials of circular rnas in rheumatic diseases[J]. Int J Biol Macromol,2023,235(12):123783.
[7]	Ji J,Zhang X,Ling Y,et al. Hsa_circ_0008301 as a potential biomarker of disease activity for primary sjogren's syndrome: Increased expression in peripheral blood of patients with primary sjogren's syndrome[J]. Int Immunopharmacol,2022,112(11):109231.
[8]	Chen L L. The biogenesis and emerging roles of circular rnas[J]. Nat Rev Mol Cell Biol,2016,17(4):205-211. doi: 10.1038/nrm.2015.32
[9]	Liu C X,Chen L L. Circular rnas: Characterization,cellular roles,and applications[J]. Cell,2022,185(12):2016-2034. doi: 10.1016/j.cell.2022.04.021
[10]	Chen X,Zhou M,Yant L,et al. Circular rna in disease: Basic properties and biomedical relevance[J]. Wiley Interdiscip Rev RNA,2022,13(6):e1723. doi: 10.1002/wrna.1723
[11]	Zhao X,Cai Y,Xu J. Circular rnas: Biogenesis,mechanism,and function in human cancers[J]. Int J Mol Sci,2019,20(16):3926. doi: 10.3390/ijms20163926
[12]	吴亚彬,刘建华,秦晓松. 环状rna在自身免疫性疾病中的研究进展[J]. 中国免疫学杂志,2021,37(19):2416-2422.
[13]	Xu C,Zhang J. Mammalian circular rnas result largely from splicing errors[J]. Cell Rep,2021,36(4):109439. doi: 10.1016/j.celrep.2021.109439
[14]	Li K,Peng Z Y,Wang R,et al. Enhancement of tki sensitivity in lung adenocarcinoma through m6a-dependent translational repression of wnt signaling by circ-fbxw7[J]. Mol Cancer,2023,22(1):103. doi: 10.1186/s12943-023-01811-0
[15]	Conn V M,Gabryelska M,Toubia J,et al. Circular rnas drive oncogenic chromosomal translocations within the mll recombinome in leukemia[J]. Cancer Cell,2023,41(7):1309-1326. doi: 10.1016/j.ccell.2023.05.002
[16]	Zhou W Y,Cai Z R,Liu J,et al. Circular rna: Metabolism,functions and interactions with proteins[J]. Mol Cancer,2020,19(1):172. doi: 10.1186/s12943-020-01286-3
[17]	Du W W,Zhang C,Yang W,et al. Identifying and characterizing circrna-protein interaction[J]. Theranostics,2017,7(17):4183-4191. doi: 10.7150/thno.21299
[18]	Zheng F,Yu X,Tang D,et al. The identification of circular rnas from peripheral blood mononuclear cells in systemic lupus erythematosus[J]. BMC Med Genomics,2021,14(1):70. doi: 10.1186/s12920-021-00919-w
[19]	Luo Q,Ye Y,Zhang L,et al. Hsa_circ_0044235 and hsa_circ_0001947 as novel biomarkers in plasma of patients with new-onset systemic lupus erythematosus[J]. J Immunotoxicol,2023,20(1):2196453. doi: 10.1080/1547691X.2023.2196453
[20]	Luo Q,Li X,Fu B,et al. Expression profile and diagnostic value of circrnas in peripheral blood from patients with systemic lupus erythematosus[J]. Mol Med Rep,2021,23(1):1.
[21]	Zheng F,Tan L,Zhang F,et al. The circrna-mirna-mrna regulatory network in plasma and peripheral blood mononuclear cells and the potential associations with the pathogenesis of systemic lupus erythematosus[J]. Clin Rheumatol,2023,42(7):1885-1896. doi: 10.1007/s10067-023-06560-5
[22]	Lu H,Yang Y,Kuang D,et al. Expression profile of circrna in peripheral blood mononuclear cells of patients with rheumatoid arthritis[J]. BMC Med Genomics,2022,15(1):1-13. doi: 10.1186/s12920-021-01143-2
[23]	Doglio M,Alexander T,Del Papa N,et al. New insights in systemic lupus erythematosus: From regulatory T cells to car-t-cell strategies[J]. J Allergy Clin Immunol,2022,150(6):1289-1301. doi: 10.1016/j.jaci.2022.08.003
[24]	Zhao X,Dong R,Tang Z,et al. Circular rna circloc101928570 suppresses systemic lupus erythematosus progression by targeting the mir-150-5p/c-myb axis[J]. J Transl Med,2022,20(1):1-16. doi: 10.1186/s12967-021-03207-4
[25]	Luan J,Jiao C,Ma C,et al. Circmtnd5 participates in renal mitochondrial injury and fibrosis by sponging mir6812 in lupus nephritis[J]. Oxid Med Cell Longev,2022,2022(1):2769487.
[26]	Liu C X,Li X,Nan F,et al. Structure and degradation of circular rnas regulate pkr activation in innate immunity[J]. Cell,2019,177(4):865-880. doi: 10.1016/j.cell.2019.03.046
[27]	Mei H Y,Liu J,Shen X P,et al. A novel circrna,circracgap1,hampers the progression of systemic lupus erythematosus via mir-22-3p-mediated akt signalling[J]. Autoimmunity,2022,55(6):360-370. doi: 10.1080/08916934.2022.2073590
[28]	Guo P W,Huang H T,Ma J,et al. Circular rna-0007059 protects cell viability and reduces inflammation in a nephritis cell model by inhibiting microrna-1278/shp-1/stat3 signaling[J]. Mol Med,2021,27(1):372-376.
[29]	Zou H,Ma S,Li L,et al. Downregulation of circular rna ets1 promotes sle activity and inhibits treg cell differentiation through mir-1205/foxp3 molecular axis[J]. Int Immunopharmacol,2024,128(3):111539.
[30]	Wang Q,Xu B,Zhang Q,et al. The role of hsa_circ_0008945 in juvenile-onset systemic lupus erythematosus[J]. BMC Med Genomics,2023,16(1):97. doi: 10.1186/s12920-023-01524-9
[31]	Luo Q,Zhang L,Li X,et al. Identification of circular rnas hsa_circ_0044235 and hsa_circ_0068367 as novel biomarkers for systemic lupus erythematosus[J]. Int J Mol Med,2019,44(4):1462-1472.
[32]	Li W,Fan R,Zhou C,et al. Circular rna expression profile of systemic lupus erythematosus and its clinical significance as a potential novel biomarker[J]. Genes Genomics,2022,44(11):1405-1414. doi: 10.1007/s13258-022-01315-z
[33]	Li S,Zhang J,Tan X,et al. Microarray expression profile of circular rnas and mrnas in children with systemic lupus erythematosus[J]. Clin Rheumatol,2019,38(5):1339-1350. doi: 10.1007/s10067-018-4392-8
[34]	Li Y,Chen J,Xie M,et al. Identification of a circrna-mirna-mrna network to explore the effects of circrnas on renal injury in systemic lupus erythematosus[J]. Autoimmunity,2023,56(1):2193361. doi: 10.1080/08916934.2023.2193361

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