Relationship between Levels of Serum 25-hydroxyvitamin D，Calcium，Zinc and Growth and Development of Children

Yuyu ZHANG; You LU; Yu LIU

doi:10.12259/j.issn.2095-610X.S20240719

Volume 45 Issue 7

Jul. 2024

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Article Navigation > Journal of Kunming Medical University > 2024 > 45(7): 126-131

Yuyu ZHANG, You LU, Yu LIU. Relationship between Levels of Serum 25-hydroxyvitamin D，Calcium，Zinc and Growth and Development of Children[J]. Journal of Kunming Medical University, 2024, 45(7): 126-131. doi: 10.12259/j.issn.2095-610X.S20240719

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Yuyu ZHANG, You LU, Yu LIU. Relationship between Levels of Serum 25-hydroxyvitamin D，Calcium，Zinc and Growth and Development of Children[J]. Journal of Kunming Medical University, 2024, 45(7): 126-131. doi: 10.12259/j.issn.2095-610X.S20240719

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Relationship between Levels of Serum 25-hydroxyvitamin D，Calcium，Zinc and Growth and Development of Children

doi: 10.12259/j.issn.2095-610X.S20240719

Yuyu ZHANG¹,
You LU²,
Yu LIU^{1
,
,}

1.
Dept. of Child Care，Zigong Maternal and Child Health Hospital，Zigong Sichuan 643000
2.
Dept. of Pediatrics，West China 2nd Hospital，Sichuan University，Chengdu Sichuan 610044，China

Received Date: 2023-12-25
Available Online: 2024-06-14
Publish Date: 2024-07-25

Abstract

Abstract

Objective To observe the levels of serum 25-hydroxyvitamin D, calcium and zinc in children, and explore the relationship between the three indexes and the growth and development of children. Methods From January 2021 to December 2022, 98 children with growth retardation treated in Zigong Maternal and Child Health Hospital were included in the growth retardation group, and 80 children with normal growth and development were taken as the normal growth and development group. The serum 25-hydroxyvitamin D, calcium , zinc level and other clinical data of the two groups were compared, and the relationship between serum 25-hydroxyvitamin D, calcium , zinc level and growth and development was analyzed. Results The levels of body length/height, weight, calcium, zinc and 25- hydroxyvitamin D in the growth retardation group were lower than those in the normal growth development group （P < 0.05）. The results of point-and-column correlation analysis showed that the levels of calcium, zinc and 25- hydroxyvitamin D were negatively correlated with children's growth retardation （r < 0, P < 0.05）. Logistic regression model was established. The results showed that the levels of Size / height （95%CI:0.673～0.824）, weight （95%CI:0.477～0.717）, calcium （95%CI: 0.127～0.467）, zinc （95%CI: 0.140～0.571） and 25- hydroxyvitamin D （95%CI: 0.130～0.461） were the protective factors for children's growth and development （or < 1 The ROC curve was drawn. The results showed that the levels of calcium, zinc and 25-hydroxyvitamin D had certain predictive value for children's growth and development （AUC = 0.601, 0.627 and 0.667）, and the predictive value of The three indicators are parallel was higher （AUC = 0.808）. Conclusion The growth and development of children is closely related to the level of serum 25-hydroxyvitamin D, calcium and zinc. Clinical monitoring of the level of serum 25-hydroxyvitamin D, calcium and zinc is helpful for early prediction of children's growth and development.
- Children,
- 25-hydroxyvitamin D,
- Calcium,
- Zinc,
- Growth and development

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